The Postmortem Brain In Psychiatric Research

Author : Galila Agam,Ian P. Everall,Robert Haim Belmaker
Publisher : Springer Science & Business Media
Page : 426 pages
File Size : 47,6 Mb
Release : 2013-03-09
Category : Psychology
ISBN : 9781475736311

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The Postmortem Brain in Psychiatric Research by Galila Agam,Ian P. Everall,Robert Haim Belmaker Pdf

Because of the dearth of experimental animal models of psychiatric disorders, the study of the effect of the disease state is only possible in tissue derived from patients vs. controls, especially in the target tissue of disease-related changes in the brain. The human postmortem brain offers the most appropriate experimental paradigm towards understanding the etiology of psychiatric disorders. The availability of post-mortem human samples from psychiatric patients and comparison groups in recent years has contributed prominently to the accumulating body of information leading to a better understanding of these disorders. This is the first book to summarize this research approach and the meaningful data which has recently been acquired.

Author : Brian Dean,Thomas M Hyde,Joel E Kleinman
Publisher : CRC Press
Page : 200 pages
File Size : 40,5 Mb
Release : 2019-02-13
Category : Medical
ISBN : 9781482283419

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Using CNS Autopsy Tissue in Psychiatric Research: A Practical Guide by Brian Dean,Thomas M Hyde,Joel E Kleinman Pdf

Essential for the laboratory, this practical manual presents a wide variety of techniques associated with the use of human CNS tissue obtained at autopsy. The book contains detailed methodologies in discrete chapters written by an expert in the specific field. It also addresses the potential for extending molecular studies in brain tissue obtain

Author : Yogesh Dwivedi
Publisher : CRC Press
Page : 485 pages
File Size : 51,5 Mb
Release : 2012-06-25
Category : Medical
ISBN : 9781439838815

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The Neurobiological Basis of Suicide by Yogesh Dwivedi Pdf

With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

Author : Brian Dean,Joel E. Kleinman,Thomas M. Hyde
Publisher : Unknown
Page : 177 pages
File Size : 54,7 Mb
Release : 1999
Category : Neuropsychiatry
ISBN : 0429271247

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Using CNS Autopsy Tissue in Psychiatric Research by Brian Dean,Joel E. Kleinman,Thomas M. Hyde Pdf

Essential for the laboratory, this practical manual presents a wide variety of techniques associated with the use of human CNS tissue obtained at autopsy. The book contains detailed methodologies in discrete chapters written by an expert in the specific field. It also addresses the potential for extending molecular studies in brain tissue obtained at autopsy into studies in living brain by using neuroimaging techniques. In addition, the reader is directed to suppliers of equipment and reagents that have been shown to be useful when studying human brain tissue.

Author : Anonim
Publisher : Elsevier
Page : 448 pages
File Size : 54,7 Mb
Release : 2018-02-27
Category : Medical
ISBN : 9780444636423

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Brain Banking by Anonim Pdf

Brain Banking, Volume 150, serves as the only book on the market offering comprehensive coverage of the functional realities of brain banking. It focuses on brain donor recruitment strategies, brain bank networks, ethical issues, brain dissection/tissue processing/tissue dissemination, neuropathological diagnosis, brain donor data, and techniques in brain tissue analysis. In accordance with massive initiatives, such as BRAIN and the EU Human Brain Project, abnormalities and potential therapeutic targets of neurological and psychiatric disorders need to be validated in human brain tissue, thus requiring substantial numbers of well characterized human brains of high tissue quality with neurological and psychiatric diseases. Offers comprehensive coverage of the functional realities of brain banking, with a focus on brain donor recruitment strategies, brain bank networks, ethical issues, and more Serves as a valuable resource for staff in existing brain banks by highlighting best practices Enhances the sharing of expertise between existing banks and highlights a range of techniques applicable to banked tissue for neuroscience researchers Authored by leaders from brain banks around the globe – the broadest, most expert coverage available

Author : Gareth W. Roberts,Julia M. Polak
Publisher : Cambridge University Press
Page : 204 pages
File Size : 48,7 Mb
Release : 1995-06-08
Category : Medical
ISBN : 0521425581

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Molecular Neuropathology by Gareth W. Roberts,Julia M. Polak Pdf

This volume provides an introduction to the essential techniques required for studying the molecular biology of brain disease. The approaches and strategies for investigations of gene structure and regulation are described with reference to the molecular genetics of prion and Alzheimer's disease. The effects of aberrant gene regulation can also be examined at the protein level by immunocytochemistry and autoradiography. Improved understanding of basic biology has resulted in new approaches to animal models using transgenic techniques and new therapeutic approaches. The volume is structured to illustrate all these approaches and demonstrate the practice and promise of molecular neuropathology.

Author : Manfred Gerlach,Jürgen Deckert,Kay Double,Eleni Koutsilieri
Publisher : Springer Science & Business Media
Page : 326 pages
File Size : 42,8 Mb
Release : 2007-12-28
Category : Medical
ISBN : 9783211735749

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Neuropsychiatric Disorders by Manfred Gerlach,Jürgen Deckert,Kay Double,Eleni Koutsilieri Pdf

This multidisciplinary book includes current research papers and reviews in the areas of basic neuroscience, neural mechanisms underlying neurodegenerative disorders. It further includes new approaches for neuroprotective treatments, clinical, neurobiological and treatment aspects of psychiatric disorders. The book was conceived as a celebration of the professional life and work of Peter Riederer to mark the occasion of his retirement.

Author : Scott E. Hemby,Sabine Bahn
Publisher : Elsevier
Page : 329 pages
File Size : 44,5 Mb
Release : 2006-10-09
Category : Science
ISBN : 9780080465630

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Functional Genomics and Proteomics in the Clinical Neurosciences by Scott E. Hemby,Sabine Bahn Pdf

The purpose of this work is to familiarize neuroscientists with the available tools for proteome research and their relative abilities and limitations. To know the identities of the thousands of different proteins in a cell, and the modifications to these proteins, along with how the amounts of both of these change in different conditions would revolutionize biology and medicine. While important strides are being made towards achieving the goal of global mRNA analysis, mRNA is not the functional endpoint of gene expression and mRNA expression may not directly equate with protein expression. There are many potential applications for proteomics in neuroscience: determination of the neuro-proteome, comparative protein expression profiling, post-translational protein modification profiling and mapping protein-protein interactions, to name but a few. Functional Genomics and Proteomics in Clinical Neuroscience will comment on all of these applications, but with an emphasis on protein expression profiling. This book combines the basic methodology of genomics and proteomics with the current applications of such technologies in understanding psychiatric illnesses. * Introduction of basic methodologies in genomics and proteomics and their integration in psychiatry* Development of the text in sections related to methods, application and future directions of these rapidly advancing technologies* Use of actual data to illustrate many principles of functional genomics and proteomics. * Introduction to bioinformatics and database management techniques

Author : R. N. Herrington
Publisher : Unknown
Page : 128 pages
File Size : 49,8 Mb
Release : 1969
Category : Electronic
ISBN : OCLC:163987229

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Current Problems in neuropsychiatry by R. N. Herrington Pdf

Author : Joel Paris
Publisher : Oxford University Press
Page : 217 pages
File Size : 43,8 Mb
Release : 2017
Category : Psychology
ISBN : 9780190601010

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Psychotherapy in an Age of Neuroscience by Joel Paris Pdf

Psychiatry, once proud of its biopsychosocial model, has now adopted a neuroscience-based approach that strongly favors psychopharmacological treatments and downplays the role of psychotherapies (or social interventions). This kind of practice can be sufficient for the psychoses, but it is neither evidence-based nor beneficial for patients with common mental disorders such as depression, anxiety, substance use, and personality disorders. Current practice derives from a theoretical model in which psychiatry is viewed primarily as an application of neuroscience, with little reference to the vast literature on psychology, social sciences, and psychotherapy. This work reviews research bearing on these issues, and it shows why existing data support a different set of conclusions from those held by many experts and most practitioners

Author : Lüder Deecke,John Eccles,Vernon B. Mountcastle
Publisher : Springer Science & Business Media
Page : 656 pages
File Size : 43,8 Mb
Release : 2013-03-09
Category : Medical
ISBN : 9783662026014

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From Neuron to Action by Lüder Deecke,John Eccles,Vernon B. Mountcastle Pdf

A rich source of information about human voluntary movement in health and disease can be found in this book. The most esteemed researchers in their respective fields bring you up-to-date articles. Their collected work combines fundamental research in the life sciences with clinical neuroscience in a unique overview. The interdisciplinary aspects of motor physiology uncover a wealth of information for researchers from neighboring disciplines. For example, oculomotor research, vestibular research, equilibrium, sensory research and cognition, evolution, synaptic and elementary processes and the neurological sciences can be discovered.

Author : Paul J. Harrison,Gareth W. Roberts
Publisher : Unknown
Page : 402 pages
File Size : 42,8 Mb
Release : 2000-08-24
Category : Medical
ISBN : UVA:X004472745

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The Neuropathology of Schizophrenia by Paul J. Harrison,Gareth W. Roberts Pdf

What is schizophrenia? This is one of the most controversial questions in psychiatry and mental health research; however, in the last twenty years, there have been significant advances in our understanding of the topic. This book provides a balanced, comprehensive and up-to-date overview of the neuropathology of schizophrenia and its interpretation, covering the latest evidence derived from all fields of research, from brain scans to microscopy. The authors include many of the foremost international authorities in this rapidly developing field.

Author : Flávio Kapczinski,Michael Berk,Pedro Vieira da Silva Magalhães
Publisher : Oxford University Press
Page : 272 pages
File Size : 45,8 Mb
Release : 2019-03-05
Category : Medical
ISBN : 9780191090882

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Neuroprogression in Psychiatry by Flávio Kapczinski,Michael Berk,Pedro Vieira da Silva Magalhães Pdf

Recent studies regarding the neuropathology of specific neurological disorders suggest that both neurodevelopmental and neurodegenerative processes may play a role. However, in contrast to the neurodegeneration seen in neurological disorders such as Parkinson's and Alzheimer's disease, the term "neuroprogression" has been used to describe the neurodevelopmental aspect of pathological brain re-wiring that takes place in the context of severe psychiatric disorders, such as schizophrenia or bipolar disorder. Within psychiatry, patients with severe psychopathology, such as those depressed patients who eventually commit suicide, have been shown to present with increased inflammatory markers in the brain. A similar increase in inflammatory markers is also found in patients with bipolar disorders and schizophrenia. Thus, oxidative stress, inflammation, and changes in growth factors are thought to be the pathways of neuroprogression. Neuroprogression in Psychiatry provides a comprehensive summary of the current developments in the emerging field of neuroprogression. With contributions by leading researchers in the field, this book examines the role of neuroprogression across a wide range of specific psychiatric disorders, with chapters included on major depressive disorder, anxiety disorder, post-traumatic stress disorder, substance abuse, schizophrenia, and bipolar disorder.

Author : Teresa L. Scheid,Tony N. Brown
Publisher : Cambridge University Press
Page : 735 pages
File Size : 49,8 Mb
Release : 2010
Category : Medical
ISBN : 9780521491945

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A Handbook for the Study of Mental Health by Teresa L. Scheid,Tony N. Brown Pdf

The second edition of A Handbook for the Study of Mental Health provides a comprehensive review of the sociology of mental health. Chapters by leading scholars and researchers present an overview of historical, social and institutional frameworks. Part I examines social factors that shape psychiatric diagnosis and the measurement of mental health and illness, theories that explain the definition and treatment of mental disorders and cultural variability. Part II investigates effects of social context, considering class, gender, race and age, and the critical role played by stress, marriage, work and social support. Part III focuses on the organization, delivery and evaluation of mental health services, including the criminalization of mental illness, the challenges posed by HIV, and the importance of stigma. This is a key research reference source that will be useful to both undergraduates and graduate students studying mental health and illness from any number of disciplines.

Author : Matcheri S. Keshavan,James L. Kennedy,Robin M. Murray
Publisher : Cambridge University Press
Page : 576 pages
File Size : 40,6 Mb
Release : 2004-11-18
Category : Medical
ISBN : 0521823315

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Neurodevelopment and Schizophrenia by Matcheri S. Keshavan,James L. Kennedy,Robin M. Murray Pdf

This book was originally published in 2004 and concerns developmental neurobiology. In the decade preceding publication, developmental neurobiology made important strides towards elucidating the pathophysiology of psychiatric disorders. Nowhere has this link between basic science and clinical insights become clearer than in the field of schizophrenia research. Each contributor to this volume provides a fresh overview of the relevant research, including directions for further investigation. The book begins with a section on advances in developmental neurobiology. This is followed by sections on etiological and pathophysiological developments, and models that integrate this knowledge. The final section addresses the clinical insights that emerge from the developmental models. This book will be valuable to researchers in psychiatry and neurobiology, students in psychology, and all mental health practitioners.