Thyroid Gland Development And Function

Author : Guy Van Vliet,Michel Polak
Publisher : Karger Medical and Scientific Publishers
Page : 203 pages
File Size : 44,7 Mb
Release : 2007-01-01
Category : Medical
ISBN : 9783805582964

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Thyroid Gland Development and Function by Guy Van Vliet,Michel Polak Pdf

As is the case in all fields of medicine, developmental endocrinology is now being studied at the molecular level. In this volume world-class researchers review the advances of the past decade in the study of normal and abnormal organogenesis of the thyroid gland and of the ontogeny of its function. They describe human thyroid development and its defects with the help of genetic studies in mouse models. Genetic defects of thyroid hormone synthesis are covered and their clinical relevance debated. The important field of thyroid cancer in the context of spontaneous occurrence and as part of familial neoplasia syndromes is described in detail. Finally, the important problem of environmental iodine deficiency which has emerged as a global public health concern is addressed. For the first time, a decade of work is presented in a concise and highly readable form. Offering valuable insight both for senior clinicians and graduate students, this publication will be of central interest to basic scientists involved in developmental biology as well as to pediatricians and endocrinologists dealing with patients with congenital disorders of thyroid function.

Author : Georg Hennemann
Publisher : Marcel Dekker
Page : 656 pages
File Size : 52,7 Mb
Release : 1986
Category : Thyroid homones
ISBN : UOM:39015010138686

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Thyroid Hormone Metabolism by Georg Hennemann Pdf

Author : G. Szinnai
Publisher : Karger Medical and Scientific Publishers
Page : 260 pages
File Size : 48,8 Mb
Release : 2014-09-15
Category : Medical
ISBN : 9783318027211

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Paediatric Thyroidology by G. Szinnai Pdf

This book presents a comprehensive overview of pediatric thyroid diseases and thus provides a useful tool for clinical problem solving. Opinion leaders in the field present reviews on all relevant diseases of the hypothalamic-pituitary-thyroid axis. Sixteen chapters cover topics ranging from fetal thyroidology, congenital hypothyroidism, central hypothyroidism, inherited defects of thyroid hormone action, cell transport and metabolism to iodine deficiency, autoimmune thyroid disease and thyroid tumors. Written by clinicians, the chapters provide in-depth information and current guidelines for clinical problems encountered in pediatric thyroidology. As a unique feature, a case seminar collection for each chapter presents typical patient histories providing key learning points and key references for clinical problem solving in family medicine, pediatric endocrinology and medical genetics. Providing a succinct update on clinical pediatric thyroidology, this book is an essential tool for pediatric and adult endocrinologists, as well as for general practitioners, pediatricians and medical geneticists.

Author : S.S. Nussey,S.A. Whitehead
Publisher : CRC Press
Page : 382 pages
File Size : 51,6 Mb
Release : 2001-06-15
Category : Medical
ISBN : 0203450434

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Endocrinology by S.S. Nussey,S.A. Whitehead Pdf

Traditionally, endocrinology textbooks have been either short notes or multi-author, multi-volume monster, all of which present clinical material last and often only briefly. Endocrinology is different and used real cases to lead readers into the text and then describes the biochemistry, physiology, and anatomy they need to understand the case. The

Author : R. Ekholm
Publisher : Springer Science & Business Media
Page : 404 pages
File Size : 52,8 Mb
Release : 2013-11-21
Category : Medical
ISBN : 9781475720587

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Control of the Thyroid Gland by R. Ekholm Pdf

Proceedings of a symposium held in Bethesda, Maryland, March 1989. The contributions address various aspects of the pituitary-thyroid axis; thyroid regulators neurogenic agents, hormones, iodide; signals and transduction; regulation of growth and function. The thyroid can serve as a model for other

Author : National Research Council,Institute of Medicine,Division on Earth and Life Studies,Board on Health Promotion and Disease Prevention,Board on Radiation Effects Research,Polar Research Board,Commission on Life Sciences,Commission on Geosciences, Environment, and Resources,Committee on Evaluation of 1950s Air Force Human Health Testing in Alaska Using Radioactive Iodine-131
Publisher : National Academies Press
Page : 116 pages
File Size : 44,6 Mb
Release : 1996-01-26
Category : Medical
ISBN : 9780309175920

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The Arctic Aeromedical Laboratory's Thyroid Function Study by National Research Council,Institute of Medicine,Division on Earth and Life Studies,Board on Health Promotion and Disease Prevention,Board on Radiation Effects Research,Polar Research Board,Commission on Life Sciences,Commission on Geosciences, Environment, and Resources,Committee on Evaluation of 1950s Air Force Human Health Testing in Alaska Using Radioactive Iodine-131 Pdf

During the 1950s, with the Cold War looming, military planners sought to know more about how to keep fighting forces fit and capable in the harsh Alaskan environment. In 1956 and 1957, the U.S. Air Force's former Arctic Aeromedical Laboratory conducted a study of the role of the thyroid in human acclimatization to cold. To measure thyroid function under various conditions, the researchers administered a radioactive medical trace, Iodine-131, to Alaska Natives and white military personnel; based on the study results, the researchers determined that the thyroid did not play a significant role in human acclimatization to cold. When this study of thyroid function was revisited at a 1993 conference on the Cold War legacy in the Arctic, serious questions were raised about the appropriateness of the activityâ€"whether it posed risks to the people involved and whether the research had been conducted within the bounds of accepted guidelines for research using human participants. In particular, there was concern over the relatively large proportion of Alaska Natives used as subjects and whether they understood the nature of the study. This book evaluates the research in detail, looking at both the possible health effects of Iodine-131 administration in humans and the ethics of human subjects research. This book presents conclusions and recommendations and is a significant addition to the nation's current reevaluation of human radiation experiments conducted during the Cold War.

Author : Institute of Medicine,Board on Health Care Services,Committee on Medicare Coverage of Routine Thyroid Screening
Publisher : National Academies Press
Page : 135 pages
File Size : 52,7 Mb
Release : 2003-09-01
Category : Medical
ISBN : 9780309088855

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Medicare Coverage of Routine Screening for Thyroid Dysfunction by Institute of Medicine,Board on Health Care Services,Committee on Medicare Coverage of Routine Thyroid Screening Pdf

When the Medicare program was established in 1965, it was viewed as a form of financial protection for the elderly against catastrophic medical expenses, primarily those related to hospitalization for unexpected illnesses. The first expansions to the program increased the eligible population from the retired to the disabled and to persons receiving chronic renal dialysis. It was not until 1980 that an expansion of services beyond those required "for the diagnosis or treatment of illness or injury or to improve the functioning of a malformed body member" was included in Medicare. These services, known as preventive services, are intended either to prevent disease (by vaccination) or to detect disease (by diagnostic test) before the symptoms of illness appear. A Committee was formed "to conduct a study on the addition of coverage of routine thyroid screening using a thyroid stimulating hormone test as a preventive benefit provided to Medicare beneficiaries under Title XVIII of the Social Security Act for some or all Medicare beneficiaries."

Author : Victor R. Preedy,Gerard N. Burrow,Ronald Ross Watson
Publisher : Academic Press
Page : 1334 pages
File Size : 55,6 Mb
Release : 2009-03-17
Category : Technology & Engineering
ISBN : 0080920861

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Comprehensive Handbook of Iodine by Victor R. Preedy,Gerard N. Burrow,Ronald Ross Watson Pdf

Over two billion people worldwide are at risk for the spectrum of disorders known as "The Iodine Deficiency Disorders." 1-10% will suffer cretinism; 5-30% will have some sort of brain damage or neurological impairment and 30-70% will be hypothyroid. The causes of iodine deficiencies can be considered from both simplistic and more complex perspectives: From the leaching of iodine from soil resulting in crops with low iodine content to malnutrition resulting in impaired iodine absorption. Poor dietary diversification and impoverished socio-economic development can also lead to iodine deficiencies. Although it is possible to diagnose and treat deficiencies, there is still an ongoing dialogue regarding the detailed molecular pathology of iodine homeostatis, how hypothyroidism impacts the body tissues, and efficient diagnosis and treatment of the Iodine Deficiency Disorders. This Handbook provides a resource of information on the various pathways and processes based on different countries or diseases. Because there is a constant flow of new information on iodine and related disorders, the goal of this Handbook is to provide a base of scientific information upon which additional knowledge can be applied. Provides important information on one of the most common micro-nutrient deficiencies in the world, the most important "single nutrient-multiple consequences" paradigm today Includes information on iodine-related diseases, including those that are common, preventable and treatable Provides insight from a broad perspective of viewpoints -- from subcellular transports to economic impact

Author : Reiko Kishi,Philippe Grandjean
Publisher : Springer Nature
Page : 554 pages
File Size : 54,5 Mb
Release : 2019-12-13
Category : Medical
ISBN : 9789811505201

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Health Impacts of Developmental Exposure to Environmental Chemicals by Reiko Kishi,Philippe Grandjean Pdf

This book provides concise and cutting-edge studies on threats resulting from exposure to environmental chemicals that can affect human health and development, with a particular emphasis on the DOHaD concept. The book is divided into five main parts, the first of which includes an introduction to the impacts of developmental exposure to environmental chemicals and historical perspectives, while the second focuses on how environmental chemicals can affect human organs, including neurodevelopment, immune functions, etc. In turn, the third part addresses the characteristics of specific chemicals and their effects on human health and development, while the fourth part provides a basis for future studies by highlighting the latest innovations in toxicology, remaining challenges, and promising strategies in children’s environmental health research, as well as ideas on how to bridge the gap between research evidence and practical policymaking. The fifth and last part outlines further research directions and related policymaking aspects. Health Impacts of Developmental Exposure to Environmental Chemicals will appeal to young and veteran researchers, students, and physicians (especially gynecologists and pediatricians) who are seeking comprehensive information on how children’s health can be affected by harmful chemicals and other environmental toxicants.

Author : Marco António Campinho,Laurent M. Sachs
Publisher : Frontiers Media SA
Page : 213 pages
File Size : 48,5 Mb
Release : 2020-01-24
Category : Electronic
ISBN : 9782889634033

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The Role of Thyroid Hormones in Vertebrate Development by Marco António Campinho,Laurent M. Sachs Pdf

Author : F. Delange,D.A. Fisher,D. Glinoer
Publisher : Springer Science & Business Media
Page : 360 pages
File Size : 50,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468475807

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Research in Congenital Hypothyroidism by F. Delange,D.A. Fisher,D. Glinoer Pdf

Systematic screening for congenital hypothyroidism in the newborn was introduced some 15 years ago. The main objective was the prevention of mental retardation due to thyroid hormone deficiency during the early months of life. During the past decade screening programs have become routine throughout most of the industrialized world and many questions relating to implementation, organization and quality control of such programs have been largely resolved. Preliminary IQ and neurological data have indicated that screening and early treatment do, in fact, prevent mental retardation. However, a number of scientific questions related to congenital hypothyroidism remain unanswered and extensive research activities are ongoing in the field. The objective of the organizers of the Brussels workshop was to focus almost exclusively on these current research aspects of the screening programs. This workshop is the third international conference specifically devoted to neonatal thyroid screening. The first was held in La Malbaie in Quebec in the fall of 1979. That meeting was well organized and highly productive. Its proceedings constitute a bible in the field. After the Quebec meeting, we witnessed major and rapid advances in our understanding of neonatal thyroid physiology as well as screening methodology, organiza tion, data management, the significance of an approach to false negative and false positive results,patient follow-up, and assessment of follow-up and treatment, and the psychoneurological evaluation of affected infants. Some of these aspects were further developed during a second highly pro ductive international conference organized in Tokyo in 1982.

Author : Clyde Michael Williams,United States. Veterans Administration
Publisher : Unknown
Page : 116 pages
File Size : 51,5 Mb
Release : 1960
Category : Radiation
ISBN : UOM:39015072221404

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Thyroid Scanning by Clyde Michael Williams,United States. Veterans Administration Pdf

Author : J. Gordon Betts,Peter DeSaix,Jody E. Johnson,Oksana Korol,Dean H. Kruse,Brandon Poe,James A. Wise,Mark Womble,Kelly A. Young
Publisher : Unknown
Page : 0 pages
File Size : 51,9 Mb
Release : 2013-04-25
Category : Electronic
ISBN : 1947172808

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Anatomy and Physiology by J. Gordon Betts,Peter DeSaix,Jody E. Johnson,Oksana Korol,Dean H. Kruse,Brandon Poe,James A. Wise,Mark Womble,Kelly A. Young Pdf

Author : Noriyuki Koibuchi,Paul M. Yen
Publisher : Springer
Page : 207 pages
File Size : 51,8 Mb
Release : 2016-11-11
Category : Medical
ISBN : 9781493937370

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Thyroid Hormone Disruption and Neurodevelopment by Noriyuki Koibuchi,Paul M. Yen Pdf

Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, the molecular mechanism of thyroid hormone action has not yet been fully understood. Thyroid hormone action in the brain may be disrupted under various pathological conditions. In addition, environmental factors including endocrine-disrupting chemicals and bacterial endotoxins may disrupt thyroid hormone action in brain, causing abnormal brain development and functional disruption. This is a first book to comprehensively describe the effect of thyroid hormone disruption in the central nervous system. The first section deals with the disruption of thyroid hormone action at the molecular level. First the authors provide a summary of the possible molecular mechanisms of thyroid hormone action in the brain, then they discuss several factors that may disrupt thyroid hormone action. In the second section, animal models to study thyroid hormone action will be introduced. An interesting character of thyroid hormone deficiency is that, without thyroid hormone, the thyroid hormone receptor may act as a “repressor” of gene expression, causing more severe consequence than those of thyroid hormone receptor knockout animals. Thus, several different kind of animal models may be used to clarify the role of thyroid hormone and its receptor in the brain. In the third section, human studies on thyroid disease and neurodevelopment will be introduced. Although endemic cretinism induced by iodine deficiency and sporadic cretinism by various thyroid mutation are well known, the pathophysiological mechanisms that create each abnormal phenotype are not fully understood. ​

Author : Antonino Belfiore,Derek LeRoith
Publisher : Springer
Page : 0 pages
File Size : 52,8 Mb
Release : 2018-02-08
Category : Medical
ISBN : 3319446746

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Principles of Endocrinology and Hormone Action by Antonino Belfiore,Derek LeRoith Pdf

This volume provides comprehensive coverage of the current knowledge of the physiology of the endocrine system and hormone synthesis and release, transport, and action at the molecular and cellular levels. It presents essential as well as in-depth information of value to both medical students and specialists in Endocrinology, Gynecology, Pediatrics, and Internal Medicine. Although it is well established that the endocrine system regulates essential functions involved in growth, reproduction, and homeostasis, it is increasingly being recognized that this complex regulatory system comprises not only hormones secreted by the classic endocrine glands but also hormones and regulatory factors produced by many organs, and involves extensive crosstalk with the neural and immune system. At the same time, our knowledge of the molecular basis of hormone action has greatly improved. Understanding this complexity of endocrine physiology is crucial to prevent endocrine disorders, to improve the sensitivity of our diagnostic tools, and to provide the rationale for pharmacological, immunological, or genetic interventions. It is such understanding that this book is designed to foster.