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Author : Herman Richard Casdorph,Morton Walker
Publisher : Penguin
Page : 436 pages
File Size : 48,7 Mb
Release : 1995
Category : Fiction
ISBN : 0895296497
"Toxic Metal Syndrome" exposes the root causes of the wastes that cause debilitating conditions and pollute the environment and explodes the myth that nothing can be done to avoid or treat them.
Author : Jerome O. Nriagu,Eric P. Skaar
Publisher : MIT Press
Page : 501 pages
File Size : 50,5 Mb
Release : 2024-06-11
Category : Medical
ISBN : 9780262552486
Experts explore the influence of trace metals on the pathogenesis of infectious diseases. Many parts of the world in which common infectious diseases are endemic also have the highest prevalence of trace metal deficiencies or rising rates of trace metal pollution. Infectious diseases can increase human susceptibility to adverse effects of metal exposure (at suboptimal or toxic levels), and metal excess or deficiency can increase the incidence or severity of infectious diseases. The co-clustering of major infectious diseases with trace metal deficiency or toxicity has created a complex web of interactions with serious but poorly understood health repercussions, yet has been largely overlooked in animal and human studies. This book focuses on the distribution, trafficking, fate, and effects of trace metals in biological systems. Its goal is to enhance our understanding of the relationships between homeostatic mechanisms of trace metals and the pathogenesis of infectious diseases. Drawing on expertise from a range of fields, the book offers a comprehensive review of current knowledge on vertebrate metal-withholding mechanisms and the strategies employed by different microbes to avoid starvation (or poisoning). Chapters summarize current, state-of-the-art techniques for investigating pathogen-metal interactions and highlight open question to guide future research. The book makes clear that improving knowledge in this area will be instrumental to the development of novel therapeutic measures against infectious diseases. Contributors M. Leigh Ackland, Vahid Fa Andisi, Angele L. Arrieta, Michael A. Bachman, J. Sabine Becker, Robert E. Black, Julia Bornhorst, Sascha Brunke, Joseph A. Caruso, Jennifer S. Cavet, Anson C. K. Chan, Christopher H. Contag, Heran Darwin, George V. Dedoussis, Rodney R. Dietert, Victor J. DiRita, Carol A. Fierke, Tamara Garcia-Barrera, David P. Giedroc, Peter-Leon Hagedoorn, James A. Imlay, Marek J. Kobylarz, Joseph Lemire, Wenwen Liu, Slade A. Loutet, Wolfgang Maret, Andreas Matusch, Trevor F. Moraes, Michael E. P. Murphy, Maribel Navarro, Jerome O. Nriagu, Ana-Maria Oros-Peusquens, Elisabeth G. Pacyna, Jozef M. Pacyna, Robert D. Perry, John M. Pettifor, Stephanie Pfaffen, Dieter Rehder, Lothar Rink, Anthony B. Schryvers, Ellen K. Silbergeld, Eric P. Skaar, Miguel C. P. Soares, Kyrre Sundseth, Dennis J. Thiele, Richard B. Thompson, Meghan M. Verstraete, Gonzalo Visbal, Fudi Wang, Mian Wang, Thomas J. Webster, Jeffrey N. Weiser, Günter Weiss, Inga Wessels, Bin Ye, Judith T. Zelikoff, Lihong Zhang
Author : Tara Lang Chapman
Publisher : iUniverse
Page : 152 pages
File Size : 49,7 Mb
Release : 2008
Category : Health & Fitness
ISBN : 9780595480562
Book claims that heavy metal poisoning is the cause of many neurological disorders, and is passed on from one generation to the next through epigenetics.
Author : Jan Aaseth,Guido Crisponi,Ole Anderson
Publisher : Academic Press
Page : 388 pages
File Size : 45,6 Mb
Release : 2016-04-18
Category : Medical
ISBN : 9780128030738
Chelation Therapy in the Treatment of Metal Intoxication presents a practical guide to the use of chelation therapy, from its basic chemistry, to available chelating antidotes, and the application of chelating agents. Several metals have long been known to be toxic to humans, and continue to pose great difficulty to treat. These challenges pose particular problems in industrial settings, with lead smelting known to be associated with hemopoietic alterations and paralyses, and the inhalation of mercury vapor in mercury mining being extremely detrimental to the central nervous system. Clinical experience has demonstrated that acute and chronic human intoxications with a range of metals can be treated efficiently by administration of chelating agents. Chelation Therapy in the Treatment of Metal Intoxication describes the chemical and biological principles of chelation in the treatment of these toxic metal compounds, including new chelators such as meso-2,3-dimercaptosuccinic acid (DMSA) and D,L-2,3-dimercapto-1-propanesulfonic acid (DMPS). Presents all the current findings on the potential for chelation as a therapy for metal intoxication Presents practical guidelines for selecting the most appropriate chelating agent Includes coverage on radionuclide exposure and metal storage diseases Describes the chemical and biological principles of chelation in the treatment of toxic metal compounds
Author : Ozgur Karcioglu,Banu Arslan
Publisher : BoD – Books on Demand
Page : 130 pages
File Size : 53,7 Mb
Release : 2019-06-19
Category : Medical
ISBN : 9781838807856
Over 400 years ago, Swiss alchemist and physician Paracelsus (1493-1541) cited: "All substances are poisons; there is none that is not a poison. The right dose differentiates a poison from a remedy." This is often condensed to: "The dose makes the poison." So, why are we overtly anxious about intoxications?In fact, poisons became a global problem with the industrial revolution. Pesticides, asbestos, occupational chemicals, air pollution, and heavy metal toxicity maintain high priority worldwide, especially in developing countries. Children between 0 and 5 years old are the most vulnerable to both acute and chronic poisonings, while older adults suffer from the chronic effects of chemicals. This book aims to raise awareness about the challenges of poisons, to help clinicians understand current issues in toxicology.
Author : John Kanayochukwu Nduka,Mohamed Nageeb Rashed
Publisher : BoD – Books on Demand
Page : 162 pages
File Size : 40,9 Mb
Release : 2020-06-24
Category : Medical
ISBN : 9781838804350
It is often said that the “dosage” of any substance determines its remedy or poison effect. Heavy metal sources encompass sewage, pesticides, fertilizers, environmental contamination, occupational exposure/contact through inhalation, ingestion, and skin. Before the advent of technology/the industrial revolution, communicable diseases ravaged the human race but this seems to have given way to non-communicable diseases such as cancers, renal failure, hormonal distortion enzymes, inhibition of fetal growth, and DNA damage causing negative health issues due to heavy metals. This book brings to the fore probably the most recent experimental research/review on heavy metal contamination, remediating techniques, cellular tissue damage, and toxicological and antioxidant effects of heavy metals. It is hoped that its contents will make interesting reading for all.
Author : Peggy L. Carver
Publisher : Walter de Gruyter GmbH & Co KG
Page : 640 pages
File Size : 48,8 Mb
Release : 2019-01-14
Category : Science
ISBN : 9783110526981
Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching.
Author : David Baker
Publisher : Oxford University Press
Page : 368 pages
File Size : 51,7 Mb
Release : 2012-03-15
Category : Medical
ISBN : 0199652546
Essentials of Toxicology for Health Protection is a key handbook and course reader for all health protection professionals. It covers the basics of toxicology and its application to issues of topical concern including contaminated land, water pollution and traditional medicines.
Author : Kahime, Kholoud,El Hidan, Moulay Abdelmonaim,El Hiba, Omar,Sereno, Denis,Bounoua, Lahouari
Publisher : IGI Global
Page : 653 pages
File Size : 55,8 Mb
Release : 2019-02-22
Category : Technology & Engineering
ISBN : 9781522577768
The faster climate change affects the globe, the faster individuals will see the negative consequences, which include the decline of general human health. Comprehension of all climate change-related etiologies is essential to understanding the importance of global environmental stability. The Handbook of Research on Global Environmental Changes and Human Health is a collection of innovative research to manage the ensuing and numerous climate and anthropogenic threats to human health. While highlighting topics including government policy, human security, and population sensitivity, this book is ideally designed for environmentalists, policymakers, sociologists, physio pathologists, epidemiologists, and students seeking current research on reducing population sensitivity in terms of health related to the different climatic risks in the changing world.
Author : Kavindra Kumar Kesari
Publisher : Springer
Page : 183 pages
File Size : 52,9 Mb
Release : 2019-05-25
Category : Medical
ISBN : 9783319965116
This book covers the latest environmental issues based on current research objectives. All chapters are fundamentally interlinked and focus on deciphering the networking of mutagens in environmental toxicity and human health. Our changing environment, climate, and lifestyle factors are growing concerns in the 21st century. The existing mutagens, either physical or chemical, are responsible for environmental toxicity. These toxicants are carcinogenic and not limited to naturally occurring chemicals or biologicals, but can also be man-made, such as 'radiation'. The networking of mutagens can have a broad range of effects on both the environment and human health. Accordingly, the respective chapters explore the networking of mutagens in connection with environmental toxicity, and address: 1. Extant types of man-made radiation and their effects on the environment and biological systems2. Heavy metal contaminations: Effects on environmental health3. Networking of environmental pollutants in the air, dust, soil, water, and natural toxins in the environment: Exposure and health4. The molecular interaction of environmental carcinogens with DNA: An oncoinformatics approach5. Fundamentals of nonotoxicity, carcinogenicity, mutagenic and neurotoxicity in environmental health6. The role of antioxidants and medicinal plants in reducing the impacts of disease-causing pollutants A sequel to Perspectives in Environmental Toxicology, this book highlights the latest developments in the field of environmental toxicology. It offers a valuable resource for researchers, scholars and graduate students alike.
Author : Gerard Marshall Raj,Ramasamy Raveendran
Publisher : Springer Nature
Page : 410 pages
File Size : 51,9 Mb
Release : 2019-11-16
Category : Medical
ISBN : 9789813297791
This book illustrates, in a comprehensive manner, the most crucial principles involved in pharmacology and allied sciences. The title begins by discussing the historical aspects of drug discovery, with up to date knowledge on Nobel Laureates in pharmacology and their significant discoveries. It then examines the general pharmacological principles - pharmacokinetics and pharmacodynamics, with in-depth information on drug transporters and interactions. In the remaining chapters, the book covers a definitive collection of topics containing essential information on the basic principles of pharmacology and how they are employed for the treatment of diseases. Readers will learn about special topics in pharmacology that are hard to find elsewhere, including issues related to environmental toxicology and the latest information on drug poisoning and treatment, analytical toxicology, toxicovigilance, and the use of molecular biology techniques in pharmacology. The book offers a valuable resource for researchers in the fields of pharmacology and toxicology, as well as students pursuing a degree in or with an interest in pharmacology.
Author : Institute of Medicine,Committee on Curriculum Development in Environmental Medicine
Publisher : National Academies Press
Page : 988 pages
File Size : 53,9 Mb
Release : 1995-05-28
Category : Medical
ISBN : 9780309051408
People are increasingly concerned about potential environmental health hazards and often ask their physicians questions such as: "Is the tap water safe to drink?" "Is it safe to live near power lines?" Unfortunately, physicians often lack the information and training related to environmental health risks needed to answer such questions. This book discusses six competency based learning objectives for all medical school students, discusses the relevance of environmental health to specific courses and clerkships, and demonstrates how to integrate environmental health into the curriculum through published case studies, some of which are included in one of the book's three appendices. Also included is a guide on where to obtain additional information for treatment, referral, and follow-up for diseases with possible environmental and/or occupational origins.
Author : Jean-Pierre Vernet
Publisher : Elsevier Publishing Company
Page : 480 pages
File Size : 49,7 Mb
Release : 1992
Category : Environmental health
ISBN : UCSD:31822016455701
Highlighted in this compilation of papers is the role and importance of heavy metals in the environment. It provides up-to-date information in a field of active research and progress, where the focus is on effects and interactions between the environment and organisms, as well as contaminant dynamics. Several papers address the impact of heavy metals on our health. The influence of metals on plants is described in an exhaustive study on lichens, which have been widely used as biomonitors for environmental contamination by heavy metals. Metals are also accumulated by animals, as seen in a chapter which focusses on sediment/benthic organism interactions and biomonitoring in fish. Soil interactions are discussed, as well as regional studies of freshwater sediments and the marine environment. The final part of the book addresses a crucial problem: the management of stabilized municipal waste sludges. As a result, the most important and significant recent trends are included, emphasizing interactions with and impacts of heavy metals on humans, animals, plants and soils.
Author : Neil Kaplowitz
Publisher : CRC Press
Page : 784 pages
File Size : 42,9 Mb
Release : 2002-10-16
Category : Medical
ISBN : 9780203909126
Featuring more than 4100 references, Drug-Induced Liver Disease will be an invaluable reference for gastroenterologists, hepatologists, family physicians, internists, pathologists, pharmacists, pharmacologists, and clinical toxicologists, and graduate and medical school students in these disciplines.
Author : Sarah E. Royce
Publisher : Unknown
Page : 60 pages
File Size : 44,6 Mb
Release : 2000
Category : Lead
ISBN : UOM:39015051606617