Transgenic Models Of Cardiac Arrhythmias And Sudden Death

Author : Carol Ann Remme
Publisher : Frontiers E-books
Page : 122 pages
File Size : 54,5 Mb
Release : 2013-06-03
Category : Electronic
ISBN : 9782889191376

Get Book

Transgenic models of cardiac arrhythmias and sudden death by Carol Ann Remme Pdf

Cardiac arrhythmias secondary to hereditary genetic disorders are increasingly recognized as a cause for sudden cardiac death in the general population. Mutations in a large number of genes encoding ion channels and proteins involved in cell-cell coupling have been identified in affected patient populations. Furthermore, genetic defects in other proteins directly or indirectly influencing cardiac electrophysiological properties have been shown to be involved. In-depth studies of the mechanisms underlying the observed electrophysiological abnormalities are often limited in patients carrying these mutations. Transgenic mouse models incorporating the genetic defect in question have been successful in studying genotype-phenotype correlations and have provided important insight into the underlying electrophysiological, biophysical, and molecular mechanisms. In this Research Topic Issue, an overview is presented of the knowledge and insight obtained from various transgenic models of cardiac electrophysiology so far, and how further research in this field may be of additional benefit for the future identification, risk-stratification, and treatment of patients with inherited cardiac arrhythmias and sudden death.

Author : James E. Tisdale
Publisher : Academic Press
Page : 378 pages
File Size : 48,9 Mb
Release : 2022-03-17
Category : Medical
ISBN : 9780128214619

Get Book

Torsades de Pointes by James E. Tisdale Pdf

Over the past 25-30 years, deaths due to Torsades de Pointes (TdP) have resulted in numerous drugs being withdrawn from the market. However, nearly 200 drugs that may prolong the QT interval and cause TdP remain available. A number of drugs with the potential to cause TdP are among the top 200 most prescribed drugs in the US, whilst new information regarding TdP is emerging rapidly. The purpose of this book is to provide a comprehensive source of information on the topic of torsades de pointes (TdP), which is a life-threatening polymorphic ventricular tachyarrhythmia associated with QT interval prolongation on the electrocardiogram (ECG). Torsades de Pointes provides a detailed, up-to-date and emerging information related to the epidemiology, drug culprits, mechanisms, risk factors, and methods of prevention and management of the life-threatening polymorphic ventricular tachycardia, also known as torsades de pointes. The book contains current knowledge, incorporating recent and cutting-edge advances in understanding of topics including inherited channelopathies and congenital LQTS; drugs that cause QT interval prolongation and TdP; non-drug causes of acquired QT interval prolongation and TdP; epidemiology of inherited and acquired TdP; morbidity and mortality associated with TdP, particularly in association with specific antimicrobials, antidepressants and antipsychotics, and methadone; cellular and molecular mechanisms of TdP, traditional and emerging risk factors for TdP; methods of prevention and risk reduction for TdP; and clinical management of patients with TdP. This book is an essential reference for both clinicians and researchers – providing guidance for clinicians who care for patients receiving QT interval-prolonging drugs, as well as cutting edge information for scientists and investigators conducting research in the area. Up-to-date information on TdP associated with inherited channelopathies and the multiple forms of congenital LQTS Includes a wealth of new information emerging regarding TdP, including newly-described risk factors and cellular and molecular mechanisms, contributions of genetic polymorphisms to drug-induced TdP, methods of quantification of risk, and methods of risk reduction, including clinical decision support Contains information on nearly 200 commonly used drugs that have the potential to cause torsades de pointes, including antimicrobials, antipsychotics, antidepressants, antiarrhythmic agents, methadone, and many others An essential reference for clinicians and researchers – provides guidance for clinicians who care for patients receiving QT interval-prolonging drugs, as well as cutting edge information for scientists and investigators conducting research in the area

Author : Spyretta Golemati,Konstantina S. Nikita
Publisher : Springer
Page : 362 pages
File Size : 49,7 Mb
Release : 2019-02-12
Category : Technology & Engineering
ISBN : 9789811050923

Get Book

Cardiovascular Computing—Methodologies and Clinical Applications by Spyretta Golemati,Konstantina S. Nikita Pdf

This book provides a comprehensive guide to the state-of-the-art in cardiovascular computing and highlights novel directions and challenges in this constantly evolving multidisciplinary field. The topics covered span a wide range of methods and clinical applications of cardiovascular computing, including advanced technologies for the acquisition and analysis of signals and images, cardiovascular informatics, and mathematical and computational modeling.

Author : J. Smeets,P.A.F.M. Doevendans,M. Josephson,Ch. Kirchhof,M. Vos
Publisher : Springer Science & Business Media
Page : 708 pages
File Size : 40,6 Mb
Release : 2000-03-31
Category : Biography & Autobiography
ISBN : 0792362098

Get Book

Professor Hein J.J. Wellens: 33 Years of Cardiology and Arrhythmology by J. Smeets,P.A.F.M. Doevendans,M. Josephson,Ch. Kirchhof,M. Vos Pdf

The first invasive evaluation of cardiac arrhythmias in humans was performed in 1967 in Paris (Prof. P. Coumel) and Amsterdam (Prof. D. Durrer). This was the start of a rapid increase in our knowledge of the diagnosis, mechanism and treatment of cardiac arrhythmias. In that same year Prof. Hein J.J. Wellens became cardiologist in the Wilhelmina Gasthuis in Amsterdam. Initially in Amsterdam (1967-1977) and later on in Maastricht (from 1977), he was the driving force for many breakthroughs in clinical cardiac electrophysiology. With an active interplay between the knowledge derived from the 12-lead electrocardiogram and the recordings made with invasive electrophysiology, he composed new ideas leading to major contributions in clinical cardiac electrophysiology and, more generally, in arrhythmology. He published over 650 scientific papers and 14 books, and had numerous functions within scientific boards of prestigious journals. In addition he trained more than 120 cardiologists in clinical cardiac electrophysiology. On the occasion of the congress `2000, Future of Arrhythmology: Lessons From the Past, Promises For Tomorrow', we highlight the scientific work of Prof. Hein J.J. Wellens. A selection of more than 60 articles over the whole time span has been selected. These articles are accompanied by comments from an expert, co-worker and/or former fellow in order to place the paper in a scientific time frame, including the relationship of the author with Prof. Hein J.J. Wellens.

Author : Anonim
Publisher : ScholarlyEditions
Page : 27 pages
File Size : 52,9 Mb
Release : 2012-12-10
Category : Medical
ISBN : 9781464981395

Get Book

Cardiac Arrhythmias: New Insights for the Healthcare Professional: 2012 Edition by Anonim Pdf

Cardiac Arrhythmias: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Cardiac Arrhythmias in a compact format. The editors have built Cardiac Arrhythmias: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cardiac Arrhythmias in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cardiac Arrhythmias: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Peter Magnusson,Jo Ann LeQuang
Publisher : BoD – Books on Demand
Page : 198 pages
File Size : 45,5 Mb
Release : 2020-11-19
Category : Medical
ISBN : 9781838800697

Get Book

Sudden Cardiac Death by Peter Magnusson,Jo Ann LeQuang Pdf

Sudden cardiac death is a global health threat for which we have only partial answers. With growing elucidation of the underlying pathophysiological mechanisms of sudden cardiac death, better patient identification and treatment options are being developed. These include risk stratification paradigms, ICD therapy, pharmacological options, ablative procedures, and other treatments. This book covers many of these options, including defibrillator technology and clinical applications. It also examines pathophysiological pathways and etiologies as well as highlights risk-stratification in ion channel diseases and structural heart disease such as dilated cardiomyopathy.

Author : Luca Fontanesi
Publisher : CABI
Page : 361 pages
File Size : 42,7 Mb
Release : 2021-06-15
Category : Technology & Engineering
ISBN : 9781780643342

Get Book

The Genetics and Genomics of the Rabbit by Luca Fontanesi Pdf

Rabbits have many uses - as well as being cherished pets, they are bred for their meat and fur, and as laboratory animals. Understanding their genetics and genomics is key to their production and, equally, to their care, welfare and health. Beginning with an introduction to the rabbit, including key information on their evolution, domestication and breed types, this book then concentrates on the genetics and genomics of this valuable animal. Concluding with practical applications such as creating transgenic and genome edited rabbits, biotechnical applications and the rabbit as a biomedical model, this book brings this important topic fully up-to-date. It provides an indispensable resource for animal and veterinary researchers and students, as well as rabbit breeders and laboratory scientists.

Author : Jun Song,Bradford Daigneault,Zhanjun Li,Huaqiang Yang
Publisher : Frontiers Media SA
Page : 186 pages
File Size : 41,5 Mb
Release : 2022-02-18
Category : Science
ISBN : 9782889744428

Get Book

Genome Editing Applications in Animal Research by Jun Song,Bradford Daigneault,Zhanjun Li,Huaqiang Yang Pdf

Author : Peter Kohl,Frederick Sachs,Michael R. Franz
Publisher : OUP Oxford
Page : 512 pages
File Size : 55,5 Mb
Release : 2011-08-25
Category : Medical
ISBN : 9780191636233

Get Book

Cardiac Mechano-Electric Coupling and Arrhythmias by Peter Kohl,Frederick Sachs,Michael R. Franz Pdf

Cardiac Mechano-Electric Coupling and Arrhythmias offers a thoroughly reviewed compendium written by leading experts in the field on the mechanism and consequences of cardiac mechano-electrical coupling. Its coverage ranges from stretch-activated ion channels to mechanically induced arrhythmias and mechanical interventions for heart rhythm correction. Information is grouped into logical sections, from molecular mechanisms, to cell, tissue and whole organ responses, right through to patient-based observations and insight emerging from clinical trials. The information provided carefully highlights both consensus insight and current shortcomings in our understanding of cardiac mechano-electric coupling. The book has been thoroughly revised and expanded since publication of the first edition in 2005, extensively updated to reflect recent developments in the field, and now offers a more balanced view of mechano-electrical interactions in the heart and develops a more clinical focus. Written with the practising cardiologist and junior doctor in mind, it offers interesting new insight for the established physician with an interest in cardiac arrhythmogenesis and heart rhythm management.

Author : Anonim
Publisher : ScholarlyEditions
Page : 59 pages
File Size : 40,5 Mb
Release : 2013-06-21
Category : Medical
ISBN : 9781481674478

Get Book

Cognitive Disorders—Advances in Research and Treatment: 2013 Edition by Anonim Pdf

Cognitive Disorders—Advances in Research and Treatment: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Cognitive Disorders—Advances in Research and Treatment: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cognitive Disorders—Advances in Research and Treatment: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Mohammad Shenasa,Gerhard Hindricks,David J. Callans,John M. Miller,Mark E. Josephson
Publisher : John Wiley & Sons
Page : 1304 pages
File Size : 52,7 Mb
Release : 2019-04-04
Category : Medical
ISBN : 9781119152620

Get Book

Cardiac Mapping by Mohammad Shenasa,Gerhard Hindricks,David J. Callans,John M. Miller,Mark E. Josephson Pdf

The expanded guide to cardiac mapping The effective diagnosis and treatment of heart disease may vitally depend upon accurate and detailed cardiac mapping. However, in an era of rapid technological advancement, medical professionals can encounter difficulties maintaining an up-to-date knowledge of current methods. This fifth edition of the much-admired Cardiac Mapping is, therefore, essential, offering a level of cutting-edge insight that is unmatched in its scope and depth. Featuring contributions from a global team of electrophysiologists, the book builds upon previous editions' comprehensive explanations of the mapping, imaging, and ablation of the heart. Nearly 100 chapters provide fascinating accounts of topics ranging from the mapping of supraventricular and ventriculararrhythmias, to compelling extrapolations of how the field might develop in the years to come. In this text, readers will find: Full coverage of all aspects of cardiac mapping, and imaging Explorations of mapping in experimental models of arrhythmias Examples of new catheter-based techniques Access to a companion website featuring additional content and illustrative video clips Cardiac Mapping is an indispensable resource for scientists, clinical electrophysiologists, cardiologists, and all physicians who care for patients with cardiac arrhythmias.

Author : Gareth D. Matthews
Publisher : Frontiers E-books
Page : 137 pages
File Size : 42,5 Mb
Release : 2014-10-02
Category : Cardiac arrest
ISBN : 9782889192694

Get Book

Sudden arrhythmic death: from basic science to clinical practice by Gareth D. Matthews Pdf

With upwards of 4.5 million deaths worldwide each year, and more than one tenth of these occurring in those with no previously documented heart disease, sudden arrhythmic death (SAD) is both a major public health burden and a highly emotive issue for society at large. Recent years have witnessed a marked expansion in our knowledge of the physiology underlying SAD, both in the context of hereditary and acquired cardiac disorders. Thanks largely to work in genetically modified animals, the growth in our understanding of mechanisms underlying arrhythmia in the hereditary channelopathies has been particularly marked. Our growing knowledge of the fundamental mechanisms underlying SAD has so far failed to spur substantial developments in clinical practice. Despite a large body of work in both humans and animals, it remains impossible to confidently identify those at high risk of SAD, making pre-emptive therapy a challenge. What is more, with the thankful exception of the implantable cardioverter-defibrillators and pharmacological agents in very specific situations, there has been depressingly little progress in finding new and effective therapies. This Research Topic aims to go some way towards bridging the gap between advances in basic science and the development and delivery of new therapies. It brings together original research contributions and review articles from key opinion leaders in the field, focusing on the direct clinical implications of the basic science research now and in the future

Author : Qingbo Xu
Publisher : John Wiley & Sons
Page : 402 pages
File Size : 49,7 Mb
Release : 2006-08-04
Category : Science
ISBN : 9780470028780

Get Book

A Handbook of Mouse Models of Cardiovascular Disease by Qingbo Xu Pdf

The availability of well-defined genetic strains and the ability to create transgenic and knockout mice makes mouse models extremely valuable biomedical tools. Their suitability as an experimental system for cardiovascular research depends on the individual investigator’s ability to manipulate the mice surgically. Many mouse models require microsurgical techniques, which hitherto could not be performed without practical training. This comprehensive handbook enables scientists to develop these models in their own laboratories. A Handbook of Mouse Models of Cardiovascular Disease is the first book to address pathology in mouse models of heart disease, providing the reader with essential information on technical assays in artificially created models. It includes background information on individual cardiovascular diseases, describes detailed methods and materials used for establishing each mouse model, discusses the problems that may appear in the experiments, and provides examples of applications of the model. A Handbook of Mouse Models of Cardiovascular Disease: Describes mouse models of all important cardiovascular diseases, including atherosclerosis, atrial fibrillation and thrombosis Features videos of key experimental procedures on the accompanying CD, allowing researchers to learn the techniques by directly watching the whole operational procedure Describes how to establish each experimental model with detailed protocols and tips on dealing with common operational problems Highlights potential applications of each model in areas such as pathogenesis, gene transfer, therapy and pathophysiology This handbook is an invaluable resource for researchers in cardiovascular disease, pathology, physiology, interested in the mechanism of vascular disorders and therapeutic approaches. It is also relevant to clinicians seeking to understand the pathology of cardiovascular disease and the rationale for interventions, and of interest to the pharmaceutical industry and all those involved in drug discovery/development for cardiovascular disease.

Author : Onkar N. Tripathi,T. Alexander Quinn,Ursula Ravens
Publisher : Springer Nature
Page : 581 pages
File Size : 51,6 Mb
Release : 2023-12-08
Category : Medical
ISBN : 9783031335884

Get Book

Heart Rate and Rhythm by Onkar N. Tripathi,T. Alexander Quinn,Ursula Ravens Pdf

This completely updated and expanded 2nd Edition provides all the information needed in order to understand the complex molecular, cellular and genetic mechanisms that underlie normal and abnormal cardiac rhythms. Its goal is to help physiologists and clinicians alike develop better preventive and treatment strategies. The respective chapters cover a broad range of topics, including the role of specific ion channels and transporters, gap junctions, intracellular Ca2+ handling in pacemaker activity, impulse conduction, and the activity of atrial and ventricular myocardium. Special emphasis is placed on the unique electrophysiology of specialized pacemaking cells and conducting fibers. In turn, several types of inherited and acquired ventricular arrhythmias are presented in detail. Clinicians will especially appreciate the updated information on even common disorders like atrial fibrillation and their impacts on human physiology. In closing, the book goes “one step further” and considers future prospects, e.g. novel antiarrhythmic agents and new concepts like optogenetics, in the context of heart rate regulation. Accordingly, it offers readers a solid reference guide to everything they need to know about human heart rate and rhythm.

Author : Mark A. Suckow,Karla A. Stevens,Ronald P. Wilson
Publisher : Academic Press
Page : 1289 pages
File Size : 49,6 Mb
Release : 2012-01-09
Category : Medical
ISBN : 9780123809209

Get Book

The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents by Mark A. Suckow,Karla A. Stevens,Ronald P. Wilson Pdf

This is a single volume, comprehensive book sanctioned by the American College of Laboratory Animal Medicine (ACLAM), covering the rabbit, guinea pig, hamster, gerbil and other rodents often used in research. This well illustrated reference includes basic biology, anatomy, physiology, behavior, infectious and noninfectious diseases, husbandry and breeding, common experimental methods, and use of the species as a research model. It is a resource for advancements in the humane and responsible care of: rabbit, guinea pig, hamster, gerbil, chinchilla, deer mouse, kangaroo rat, cotton rat, sand rat, and degu Includes up-to-date, common experimental methods. Organized by species for easy access during bench research.