Tumor Microenvironments In Organs

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Tumor Microenvironments in Organs

Anonim
Tumor Microenvironments in Organs Book PDF

Author : Anonim
Publisher : Unknown
Page : 155 pages
File Size : 41,7 Mb
Release : 2020
Category : Cancer
ISBN : 3030362159

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Tumor Microenvironments in Organs by Anonim Pdf

Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the tumor microenvironment in over thirty human organs, including the parathyroid gland, heart, intestine, testicles, and more. Taken alongside its companion volumes, these books update us on what we know about the different aspects of the tumor microenvironments in distinct organs as well as future directions. Tumor Microenvironments in Organs: From the Brain to the Skin - Part A is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.

Tumor Microenvironments in Organs

Alexander Birbrair
Tumor Microenvironments in Organs Book PDF

Author : Alexander Birbrair
Publisher : Springer Nature
Page : 155 pages
File Size : 44,8 Mb
Release : 2020-02-06
Category : Science
ISBN : 9783030362140

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Tumor Microenvironments in Organs by Alexander Birbrair Pdf

Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the tumor microenvironment in over thirty human organs, including the parathyroid gland, heart, intestine, testicles, and more. Taken alongside its companion volumes, these books update us on what we know about the different aspects of the tumor microenvironments in distinct organs as well as future directions. Tumor Microenvironments in Organs: From the Brain to the Skin – Part A is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.

Tumor Microenvironments in Organs

Alexander Birbrair
Tumor Microenvironments in Organs Book PDF

Author : Alexander Birbrair
Publisher : Springer Nature
Page : 376 pages
File Size : 44,9 Mb
Release : 2021-06-29
Category : Medical
ISBN : 9783030590383

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Tumor Microenvironments in Organs by Alexander Birbrair Pdf

Revealing essential roles of the tumor microenvironment components in cancer progression, this book provides a comprehensive overview of the latest research on the tumor microenvironment in several organs, including brain, neck, tongue, larynges, esophagus, carotid body, breast, prostate, ovary, endometrium, liver, pancreas, bladder, penis, seminal vesicle, retina, and pituitary, pineal and sweat glands, and more. Taken alongside its companion volumes, Tumor Microenvironments in Organs: From the Brain to the Skin – Part B updates us on what we know about the different aspects of the tumor microenvironments in distinct organs as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.

Tumor Microenvironment

Alexander Birbrair
Tumor Microenvironment Book PDF

Author : Alexander Birbrair
Publisher : Springer Nature
Page : 548 pages
File Size : 53,9 Mb
Release : 2021-10-18
Category : Medical
ISBN : 9783030731199

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Tumor Microenvironment by Alexander Birbrair Pdf

This volume discusses novel concepts in cancer biology, focusing on different factors that affect the tumor microenvironment. Topics covered include sex-based differences in the tumor microenironment, dormancy in the tumor microenvironment, the influence of obesity on the tumor microenvironment, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Novel Concepts covers the latest research on various aspects of the tumor microenvironment, as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists studied the tumor microenvironment as well as how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students, as well as researchers seeking an update on research on the tumor microenvironment.

Tumor Microenvironment

Jacinta Serpa
Tumor Microenvironment Book PDF

Author : Jacinta Serpa
Publisher : Springer Nature
Page : 430 pages
File Size : 54,6 Mb
Release : 2020-03-04
Category : Medical
ISBN : 9783030340254

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Tumor Microenvironment by Jacinta Serpa Pdf

The way a cell undergoes malignant transformation should meet their capacity of surviving in the microenvironment of the organ where the cancer will develop. Metabolic adaptation is for sure one of the criteria that must be accomplished, driven by metabolic plasticity that allows the adaptation of cancer cells to the availability of energy and biomass sources that will sustain cell survival and proliferation. Each human organ has a particular microenvironment which depends on several cell types and in some cases also on symbiotic microorganisms. These biological partners are constantly sharing organic compounds and signaling molecules that will control mitogenesis, cell death and differentiation, accounting for the organ's function. Nevertheless, cancer cells are capable of taking advantage of this metabolic and signaling microenvironmental dynamics. In this book, we intend to present the different components of the microenvironment driving the metabolic fitness of cancer cells. The metabolic changes required for establishing a tumor in a given microenvironment and how these metabolic changes limit the response to drugs will generally be the major items addressed. It is important to mention not only aspects of the microenvironment that stimulate metabolic changes and that select better adapted tumor cells, but also how this regulation of cell plasticity is made. Thus, the signaling pathways that orchestrate and are orchestrated throughout this panoply of metabolic rearrangements will also be addressed in this book. The subjects will be presented from the conceptual point of view of the cross-cancer mechanisms and also particularizing some models that can be examples and enlightening within the different areas.

Tumor Microenvironment Regulation of Tumor Expansion

Domenico Ribatti
Tumor Microenvironment Regulation of Tumor Expansion Book PDF

Author : Domenico Ribatti
Publisher : Academic Press
Page : 172 pages
File Size : 55,8 Mb
Release : 2021-04-04
Category : Science
ISBN : 9780128228043

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Tumor Microenvironment Regulation of Tumor Expansion by Domenico Ribatti Pdf

Tumor Microenvironment Regulation of Tumor Expansion is a practical guide to understand and perform research on tumor microenvironments, and to support related clinical decisions. Tumor progression is linked to an imbalance between positive and negative regulators, and mainly depends on the release of specific growth factors by inflammatory or neoplastic cells. Inflammatory infiltrate contributes to tumor progression and the metastatic process, and there are many reports of associations between tumor inflammatory infiltrate, progression, and prognosis. Understanding different contexts of organs is a key factor in improving treatment outcome, especially in new therapeutic treatments targeting components of the tumor microenvironment. This book is a valuable resource for cancer researchers, clinicians, graduate students, and scientists in many biomedical fields who are interested in the complex relationship between the tumor microenvironment and its context in specific organs. Provides a holistic approach to understanding the crucial role of the tumor microenvironment in tumor progression Encompasses the basic knowledge necessary to understand and undertake further studies related to tumor microenvironments Discusses new therapeutic approaches developed to control tumor progression by targeting different components of the tumor microenvironment

The Heterogeneity of Cancer Metabolism

Anne Le
The Heterogeneity of Cancer Metabolism Book PDF

Author : Anne Le
Publisher : Springer
Page : 186 pages
File Size : 46,5 Mb
Release : 2018-06-26
Category : Medical
ISBN : 9783319777368

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The Heterogeneity of Cancer Metabolism by Anne Le Pdf

Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Tumor Microenvironment

Jacinta Serpa
Tumor Microenvironment Book PDF

Author : Jacinta Serpa
Publisher : Unknown
Page : 128 pages
File Size : 47,6 Mb
Release : 2020
Category : Cancer cells
ISBN : 3030340260

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Tumor Microenvironment by Jacinta Serpa Pdf

This book will allow readers to discover the crucial role of tumor microenvironment (TME) in the selection of cancer cells that are more prone to carry on cancer initiation and progression. The metabolic remodeling, as the basis of life overall, allows the adaptive establishment of a tumor in a certain TME, which in turn presents a variety of selective pressures. Coupled with the late diagnosis, the poor therapy response are the main hurdles limiting oncological disease control and eventual cure. Thus the metabolic plasticity of cancer cells often underlies chemoresistance. This edited work presents an exhaustive description and comprehensive view of cancer metabolism as a weapon used by cancer cells to adapt to TME. TME and the organ microenvironment is analyzed as a whole, considering cancer cells, stromal cells and microbiota. This complex circuit is observed as the support for disease development and therapy evasion but also as a valuable kernel, presenting new players to be targeted in a more precise cancer therapy. The various threads of cancer biology related to TME and metabolic adaptation will be addressed including: 1) key players in the metabolic network; 2) the way adaptive metabolic features are sustained by TME; 3) TME and metabolic signaling, accounting for cancer cells survival; 4) metabolic fitness driven limitations in therapy response, and 5) the way TME and cancer metabolism can be helpful in the design of new drugs. In addition, the usefulness, technical strengths and weaknesses of analytical techniques useful in cancer metabolomics will be presented in an integrative way. Moreover, the use of innovative and traditional in vitro and in vivo cancer models, as powerful tools to address the influence of TME in cancer progression and metabolic reprogramming will be also presented. This work was written by experts and dedicated to researchers with interests in cancer biology, TME, cancer metabolism and therapy. It will interest the Advances in Experimental Medicine and Biology readership, including basic researchers, analytic researchers, bio-engineers and clinicians.

Tumor Microenvironment: Cellular, Metabolic and Immunologic Interactions

Debabrata Banerjee,Raj K. Tiwari
Tumor Microenvironment Cellular Metabolic and Immunologic Interactions Book PDF

Author : Debabrata Banerjee,Raj K. Tiwari
Publisher : Springer Nature
Page : 171 pages
File Size : 49,7 Mb
Release : 2021-12-09
Category : Medical
ISBN : 9783030832827

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Tumor Microenvironment: Cellular, Metabolic and Immunologic Interactions by Debabrata Banerjee,Raj K. Tiwari Pdf

Over the past decade, the tumor microenvironment has become one of the most important research areas in cancer biology, as cells within the tumor microenvironment, despite being outnumbered by healthy cells, are able to evade surveillance and immune-mediated destruction. While researchers have learned a great deal about the cellular and structural makeup of the tumor microenvironment, there has been a growing understanding of the metabolic interplay between the tumor micronenvironment’s various cellular constituents and how each of them contributes to overall tumor growth and metastases. This new volume will guide researchers, students, oncologists and academics through a rapidly developing and changing field with a thorough understanding of tumor microenvironment biology from a cellular, structural, metabolic, and immunological perspective.

Current Advances in the Science of Osteosarcoma

Eugenie S. Kleinerman,Richard Gorlick
Current Advances in the Science of Osteosarcoma Book PDF

Author : Eugenie S. Kleinerman,Richard Gorlick
Publisher : Springer Nature
Page : 233 pages
File Size : 54,5 Mb
Release : 2020-08-07
Category : Medical
ISBN : 9783030430856

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Current Advances in the Science of Osteosarcoma by Eugenie S. Kleinerman,Richard Gorlick Pdf

This thoroughly revised second edition is an up-to-date overview of the new advances in the knowledge of the basic science in sarcoma and osteosarcoma. It features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, this essential volume also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists.

Tumor Microenvironment

Alexander Birbrair
Tumor Microenvironment Book PDF

Author : Alexander Birbrair
Publisher : Springer Nature
Page : 153 pages
File Size : 52,5 Mb
Release : 2020-02-08
Category : Science
ISBN : 9783030357238

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Tumor Microenvironment by Alexander Birbrair Pdf

Revealing essential roles of the tumor microenvironment in cancer progression, this book focuses on the role of hematopoietic components of the tumor microenvironment. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include neutrophils, basophils, T helper cells, cytotoxic lymphocytes, fibrocytes, and myeloid-derived suppressor cells, and more. Taken alongside its companion volumes, these books update us on what we know about various aspects of the tumor microenvironment as well as future directions. Tumor Microenvironment: Hematopoietic Cells – Part A is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.

Biomarkers of the Tumor Microenvironment

Lars A. Akslen,Randolph S. Watnick
Biomarkers of the Tumor Microenvironment Book PDF

Author : Lars A. Akslen,Randolph S. Watnick
Publisher : Springer
Page : 534 pages
File Size : 50,8 Mb
Release : 2017-08-02
Category : Medical
ISBN : 9783319391472

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Biomarkers of the Tumor Microenvironment by Lars A. Akslen,Randolph S. Watnick Pdf

This book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Practical applications, in terms of how biomarkers are increasingly included in therapy protocols, will also be discussed. Biomarkers of the Tumor Microenvironment: Basic Studies and Practical Applications is aimed at research pathologists in the cancer field, and also cancer researchers from other backgrounds, especially those using morphology techniques and models focusing on cross-talk between different cell types in tumors.

The Tumor Immunoenvironment

Michael R Shurin,Viktor Umansky,Anatoli Malyguine
The Tumor Immunoenvironment Book PDF

Author : Michael R Shurin,Viktor Umansky,Anatoli Malyguine
Publisher : Springer
Page : 0 pages
File Size : 45,8 Mb
Release : 2016-08-23
Category : Medical
ISBN : 9402401482

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The Tumor Immunoenvironment by Michael R Shurin,Viktor Umansky,Anatoli Malyguine Pdf

Analysis of multidirectional immunological responses at the tumor site allows forming a new concept of The Tumor Immunoenvironment, which is introduced and discussed in the present book with a particular focus on the role of immune cells in controlling the tumor microenvironment at different stages of cancer development. The main goal of this publication is to provide an overview of the current knowledge on the complex and unique role of the immune system, tumor-associated inflammation and tumor-mediated immunomodulation in cancer progression in a way that allows understanding the logistics of cellular and molecular interactions in the tumor lesions.

Tumor Organoids

Shay Soker,Aleksander Skardal
Tumor Organoids Book PDF

Author : Shay Soker,Aleksander Skardal
Publisher : Humana Press
Page : 213 pages
File Size : 45,8 Mb
Release : 2017-10-20
Category : Medical
ISBN : 9783319605111

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Tumor Organoids by Shay Soker,Aleksander Skardal Pdf

Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer

Michail Ignatiadis,Christos Sotiriou,Klaus Pantel
Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer Book PDF

Author : Michail Ignatiadis,Christos Sotiriou,Klaus Pantel
Publisher : Springer Science & Business Media
Page : 245 pages
File Size : 42,7 Mb
Release : 2012-04-23
Category : Medical
ISBN : 9783642281600

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Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer by Michail Ignatiadis,Christos Sotiriou,Klaus Pantel Pdf

This important book provides up-to-date information on a series of topical issues relating to the approach to minimal residual disease in breast cancer patients. It first explains how the study of minimal residual disease and circulating and disseminated tumor cells (CTCs/DTCs) can assist in the understanding of breast cancer metastasis. A series of chapters then discuss the various technologies available for the detection and characterization of CTCs and DTCs, pinpointing their merits and limitations. Detailed consideration is given to the relevance of CTCs and DTCs, and their detection, to clinical research and practice. The role of other blood-based biomarkers is also addressed, and the closing chapters debate the challenges facing drug and biomarker co-development and the use of CTCs for companion diagnostic development. This book will be of interest and assistance to all who are engaged in the modern management of breast cancer.