Basic Concepts Of Molecular Pathology

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Basic Concepts of Molecular Pathology

Philip T. Cagle,Timothy Craig Allen
Basic Concepts of Molecular Pathology Book PDF

Author : Philip T. Cagle,Timothy Craig Allen
Publisher : Springer Science & Business Media
Page : 195 pages
File Size : 51,5 Mb
Release : 2009-06-10
Category : Medical
ISBN : 9780387896267

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Basic Concepts of Molecular Pathology by Philip T. Cagle,Timothy Craig Allen Pdf

Over the past two decades there has been an explosion in knowledge about the molecular pathology of human diseases which accelerated with the sequencing of the human genome in 2003. Molecular diagnostics and molecular targeted therapy have contributed to the current concept of personalized patient care that is now routine in many medical centers. As a result, general and subspecialty pathologists, clinical practitioners of all types and radiologists must now have an understanding of the basic concepts of molecular pathology and their role in new diagnostic and therapeutic applications to patient care. The Molecular Pathology Library series was created to bridge the gap between traditional basic science textbooks in molecular biology and traditional medical textbooks for organ-specific diseases. Basic Concepts of Molecular Pathology is designed as a stand-alone book to provide the pathologist, clinician or radiologist with a concise review of the essential terminology, concepts and tools of molecular biology that are applied to the understanding, diagnosis and treatment of human diseases in the age of personalized medicine. Those medical practitioners, residents, fellows and students who need to refer to the terminology and concepts of molecular pathology in their patient care will find the Basic Concepts of Molecular Pathology to be a succinct, portable, user-friendly aid in their practice and studies. The service-based physician will find this handy reference to be valuable at the laboratory benchside, at the patient bedside, at multidisciplinary patient care conferences or as a review for examinations.

Essential Concepts in Molecular Pathology

William B. Coleman,Gregory J. Tsongalis
Essential Concepts in Molecular Pathology Book PDF

Author : William B. Coleman,Gregory J. Tsongalis
Publisher : Academic Press
Page : 634 pages
File Size : 42,5 Mb
Release : 2019-11-23
Category : Medical
ISBN : 9780128132586

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Essential Concepts in Molecular Pathology by William B. Coleman,Gregory J. Tsongalis Pdf

Essential Concepts in Molecular Pathology, Second Edition, offers an introduction to molecular genetics and the "molecular" aspects of human disease. The book illustrates how pathologists harness their understanding of these entities to develop new diagnostics and treatments for various human diseases. This new edition offers pathology, genetics residents, and molecular pathology fellows an advanced understanding of the molecular mechanisms of disease that goes beyond what they learned in medical and graduate school. By bridging molecular concepts of pathogenesis to the clinical expression of disease in cell, tissue and organ, this fully updated, introductory reference provides the background necessary for an understanding of today’s advances in pathology and medicine. Explains the practice of "molecular medicine" and the translational aspects of molecular pathology, including molecular diagnostics, molecular assessment and personalized medicine Orients non-pathologists on what pathologists look for and how they interpret their observational findings based on histopathology Provides the reader with what is missing from most targeted introductions to pathology—the cell biology behind pathophysiology

Molecular Pathology

William B. Coleman,Gregory J. Tsongalis
Molecular Pathology Book PDF

Author : William B. Coleman,Gregory J. Tsongalis
Publisher : Academic Press
Page : 802 pages
File Size : 40,9 Mb
Release : 2017-11-09
Category : Medical
ISBN : 9780128027875

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Molecular Pathology by William B. Coleman,Gregory J. Tsongalis Pdf

As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states. Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease Explains the practice of “molecular medicine and the translational aspects of molecular pathology Teaches from the perspective of “integrative systems biology Enhanced digital version included with purchase

Diagnostic Molecular Pathology

William B. Coleman,Gregory J. Tsongalis
Diagnostic Molecular Pathology Book PDF

Author : William B. Coleman,Gregory J. Tsongalis
Publisher : Academic Press
Page : 846 pages
File Size : 48,8 Mb
Release : 2023-10-27
Category : Science
ISBN : 9780128229934

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Diagnostic Molecular Pathology by William B. Coleman,Gregory J. Tsongalis Pdf

Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing, Second Edition assembles a group of experts to discuss the molecular basis and mechanisms of major human diseases and disease processes and how the molecular features of disease can be harnessed to develop practical molecular tests for disease detection, diagnosis and prognosis. The book explains how molecular tests are utilized in the treatment of patients in personalized medicine, highlights new technologies and approaches of applied molecular pathology, and discusses how this discovery-based research yields new and useful biomarkers and tests. As it is essential to stay up-to-date on new molecular diagnostics in this changing field, this book covers critically important areas in the practice of personalized medicine and reflects our understanding of the pathology, pathogenesis and pathophysiology of human disease. Includes new material on mass spectrometry for infectious diseases, microbiome, homology-directed repair for PARPi, whole genome sequencing for constitutional testing, and much more Provides insights on the value of the molecular test in comparison to traditional methods, which include speed, precision, sensitivity and clinical impacts for the patient Focuses on the menu of molecular diagnostic tests available in modern molecular pathology or clinical laboratories that can be applied to disease detection, diagnosis and classification in the clinical workup of a patient Explains how molecular tests are utilized to guide the treatment of patients in personalized medicine (guided therapies) and for the prognostication of disease

Principles of Molecular Pathology

Anthony Killeen
Principles of Molecular Pathology Book PDF

Author : Anthony Killeen
Publisher : Springer Science & Business Media
Page : 247 pages
File Size : 40,6 Mb
Release : 2003-11-07
Category : Medical
ISBN : 9781592594313

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Principles of Molecular Pathology by Anthony Killeen Pdf

Anthony Killeen, MD, PhD, offers a comprehensive yet concise introduction to molecular pathology that encompasses both applied and theoretical knowledge. Writing in a very readable style, the author reviews the basic concepts of human molecular biology, explains the principles of the most commonly used analytical methods, and discusses the molecular principles that underlie both inherited diseases and acquired genetic abnormalities that lead to cancer. Using common viral infections as examples, the book applies these molecular methods to the detection of microbial pathogens. The growing importance of pharmacogenetics and identity testing in the clinical laboratory is also highlighted.

Precision Molecular Pathology of Bladder Cancer

Donna E. Hansel,Seth P. Lerner
Precision Molecular Pathology of Bladder Cancer Book PDF

Author : Donna E. Hansel,Seth P. Lerner
Publisher : Springer
Page : 243 pages
File Size : 41,8 Mb
Release : 2018-01-05
Category : Medical
ISBN : 9783319647692

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Precision Molecular Pathology of Bladder Cancer by Donna E. Hansel,Seth P. Lerner Pdf

This succinct yet comprehensive volume describes current and emerging concepts in molecular pathology of bladder cancer. Divided into two distinct sections, the first part focuses on the general principles of molecular findings in bladder cancer, while the second part focuses on the molecular changes associated with specific histologic subtypes. The volume also addresses such topics as molecular alterations in non-invasive and invasive disease, including bladder cancer variants as appropriate, emerging molecular classifiers of bladder cancer, and molecular associations to outcome and treatment. Written by experts in the field, Precision Molecular Pathology of Bladder Cancer is a valuable resource for those in the urologic community, including urologic pathologists, urologists, urologic oncologists and radiation oncologists, who treat and manage bladder cancer.

Molecular Pathology of Liver Diseases

Satdarshan P. S. Monga
Molecular Pathology of Liver Diseases Book PDF

Author : Satdarshan P. S. Monga
Publisher : Springer Science & Business Media
Page : 920 pages
File Size : 50,7 Mb
Release : 2010-12-14
Category : Medical
ISBN : 9781441971074

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Molecular Pathology of Liver Diseases by Satdarshan P. S. Monga Pdf

Cellular and Molecular Pathology of the Liver is extensive, complex and ranges from the understanding the basic molecular mechanisms that dictate everything from liver homeostasis to liver disease. Molecular Pathology of the liver is complicated due to some of the important functions inherent and unique to the Liver, including its innate ability to regenerate and the multitude of functions it plays for the wellbeing of an organism. With all this in mind, Molecular Pathology of Liver Diseases is organized in different sections, which will coherently and cohesively present the molecular basis of hepatic physiology and pathology. The first two sections are key to understanding the liver anatomy and physiology at a cellular level and go on to define the molecular mechanics in various liver cell types. These sections also cover the existing paradigms in liver development, regeneration and growth. The next section is key to understanding the Molecular Pathology unique to liver diseases and associated phenotypes. The final sections are geared towards the existing knowledge of the molecular basis of many common and uncommon liver diseases in both neoplastic and non-neoplastic areas including pathologies associated with intra-hepatic and extra-hepatic biliary tree. Thus, this textbook is a one-stop reference for comprehending the molecular mechanisms of hepatic pathobiology. It is clearly unique in its format, readability and information and thus will be an asset to many in the field of Pathology and other disciplines.

Principles and Applications of Molecular Diagnostics

Nader Rifai,A. Rita Horvath,Carl T. Wittwer,Jason Park
Principles and Applications of Molecular Diagnostics Book PDF

Author : Nader Rifai,A. Rita Horvath,Carl T. Wittwer,Jason Park
Publisher : Elsevier
Page : 422 pages
File Size : 54,5 Mb
Release : 2018-06-13
Category : Science
ISBN : 9780128160626

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Principles and Applications of Molecular Diagnostics by Nader Rifai,A. Rita Horvath,Carl T. Wittwer,Jason Park Pdf

Principles and Applications of Molecular Diagnostics serves as a comprehensive guide for clinical laboratory professionals applying molecular technology to clinical diagnosis. The first half of the book covers principles and analytical concepts in molecular diagnostics such as genomes and variants, nucleic acids isolation and amplification methods, and measurement techniques, circulating tumor cells, and plasma DNA; the second half presents clinical applications of molecular diagnostics in genetic disease, infectious disease, hematopoietic malignancies, solid tumors, prenatal diagnosis, pharmacogenetics, and identity testing. A thorough yet succinct guide to using molecular testing technology, Principles and Applications of Molecular Diagnostics is an essential resource for laboratory professionals, biologists, chemists, pharmaceutical and biotech researchers, and manufacturers of molecular diagnostics kits and instruments. Explains the principles and tools of molecular biology Describes standard and state-of-the-art molecular techniques for obtaining qualitative and quantitative results Provides a detailed description of current molecular applications used to solve diagnostics tasks

Cell and Tissue Based Molecular Pathology E-Book

Raymond R. Tubbs,Mark H. Stoler
Cell and Tissue Based Molecular Pathology E Book Book PDF

Author : Raymond R. Tubbs,Mark H. Stoler
Publisher : Elsevier Health Sciences
Page : 452 pages
File Size : 44,7 Mb
Release : 2008-09-22
Category : Medical
ISBN : 9781437719482

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Cell and Tissue Based Molecular Pathology E-Book by Raymond R. Tubbs,Mark H. Stoler Pdf

This volume in the Foundations in Diagnostic Pathology Series packs today's most essential cell and tissue base molecular pathology into a compact, high-yield format! It focuses on the state of the art in practical validated molecular diagnostics as applied across the fields of surgical pathology and cytology. With an emphasis on current, clinically valid, and diagnostically important applications today and in the near future, you can be assured you’re getting the most up-to-date, authoritative coverage available. Its pragmatic, well-organized approach, nearly 250 full-color illustrations, and at-a-glance boxes and tables make the information you need easy to access. Practical and affordable, this resource is ideal for study and review as well as everyday clinical practice! Offers detailed discussions on today’s technologies to help you select the best test for case evaluation. Presents recognized molecular pathologists who convey the most current information, keeping you on the cusp of your field. Features nearly 250 full-color illustrations that present important pathologic features, enabling you to form a differential diagnosis and compare your findings with actual cases. Uses a consistent, user-friendly format, including at-a-glance boxes and tables for easy reference.

Molecular Pathology

William B. Coleman,Gregory J. Tsongalis
Molecular Pathology Book PDF

Author : William B. Coleman,Gregory J. Tsongalis
Publisher : Academic Press
Page : 659 pages
File Size : 52,8 Mb
Release : 2009-03-10
Category : Medical
ISBN : 9780123859129

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Molecular Pathology by William B. Coleman,Gregory J. Tsongalis Pdf

Molecular Pathology: The Molecular Basis of Human Disease provides a current and comprehensive view of the molecular basis and mechanisms of human disease. Combining accepted principles with broader theoretical concepts and with contributions from a group of experts, the book looks into disease processes in the context of traditional pathology and their implications for translational molecular medicine. It also discusses concepts in molecular biology and genetics, recent scientific and technological advances in modern pathology, the concept of ""molecular pathogenesis"" of disease, and how disease evolves from normal cells and tissues due to perturbations in molecular pathways. The book describes the integration of molecular and cellular pathogenesis using a bioinformatics approach and a systems biology approach to disease pathogenesis. It also discusses current and future strategies in molecular diagnosis of human disease, and the impact of molecular diagnosis on treatment decisions and the practice of personalized medicine. This book is a valuable resource for students, biomedical researchers, practicing physician-scientists who undertake disease-related basic science and translational research, and pathology residents and other postdoctoral fellows. * Exam Master® web site will host "Self-assessment" questions that students can use to study for the molecular section of the board exam * Companion Web Site – will host a complete set of PowerPoint slides: to include images from the book and additional images for teaching; course materials; lecture materials * Teaches from the perspective of “integrative systems biology, which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease * Outlines the principles and practice of molecular pathology * Explains the practice of “molecular medicine and the translational aspects of molecular pathology

Molecular Genetic Pathology

Liang Cheng,David Y. Zhang,John N. Eble
Molecular Genetic Pathology Book PDF

Author : Liang Cheng,David Y. Zhang,John N. Eble
Publisher : Springer
Page : 1136 pages
File Size : 40,9 Mb
Release : 2013-03-05
Category : Medical
ISBN : 1461447992

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Molecular Genetic Pathology by Liang Cheng,David Y. Zhang,John N. Eble Pdf

Molecular Genetic Pathology, Second Edition presents up-to-date material containing fundamental information relevant to the clinical practice of molecular genetic pathology. Fully updated in each area and expanded to include identification of new infectious agents (H1N1), new diagnostic biomarkers and biomarkers for targeted cancer therapy. This edition is also expanded to include the many new technologies that have become available in the past few years such as microarray (AmpliChip) and high throughput deep sequencing, which will certainly change the clinical practice of molecular genetic pathology. Part I examines the clinical aspects of molecular biology and technology, genomics. Poharmacogenomics and proteomics, while Part II covers the clinically relevant information of medical genetics, hematology, transfusion medicine, oncology, and forensic pathology. Supplemented with many useful figures and presented in a helpful bullet-point format, Molecular Genetic Pathology, Second Edition provides a unique reference for practicing pathologists, oncologists, internists, and medical genetisists. Furthermore, a book with concise overview of the field and highlights of clinical applications will certainly help those trainees, including pathology residents, genetics residents, molecular pathology fellows, internists, hematology/oncology fellows, and medical technologists in preparing for their board examination/certification.

Diagnostic Molecular Pathology

Debra G. B. Leonard
Diagnostic Molecular Pathology Book PDF

Author : Debra G. B. Leonard
Publisher : Saunders
Page : 236 pages
File Size : 46,8 Mb
Release : 2003
Category : Medical
ISBN : UOM:39015057599691

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Diagnostic Molecular Pathology by Debra G. B. Leonard Pdf

This practical guide provides information essential to understanding the significance of molecular biology and its application to everyday practice. Coverage focuses on the spectrum of currently used molecular tests in the areas of hematopathology, solid tumors, genetics, and identify testing. Examples of both molecular and cytogenetic assays demonstrate how these tests are used in today's pathology labs to detect a wide range of infectious diseases and inherited and metabolic conditions.

Molecular Pathology of Alzheimer's Disease

Rudy Castellani,George Perry
Molecular Pathology of Alzheimer s Disease Book PDF

Author : Rudy Castellani,George Perry
Publisher : Biota Publishing
Page : 93 pages
File Size : 50,9 Mb
Release : 2013-10-01
Category : Health & Fitness
ISBN : 9781615046393

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Molecular Pathology of Alzheimer's Disease by Rudy Castellani,George Perry Pdf

Alzheimer’s Disease is characterized pathologically by two principal hallmark lesions: the senile plaque and the neurofibrillary tangle. Since the identification of each over 100 years ago, the major protein components have been elucidated. This has led in turn to the elaboration of metabolic cascades involving amyloid-β production in the case of the senile plaque, and phosphorylated-tau protein in the case of the neurofibrillary tangle. The pathogenesis and histogenesis of each have been the source of extensive investigation and some controversy in recent years, as both cascades have been implicated in the pathogenesis of Alzheimer’s Disease, relied upon in the diagnostic criteria for Alzheimer’s Disease at autopsy, and targeted for therapeutic intervention. With the accumulation of data and expansion of knowledge of the molecular biology of Alzheimer’s Disease, it appears that the enthusiasm for successful intervention has been premature. In this book, we detail the discovery and characterization of the major pathological lesions, their associated molecular biology, their relationship to clinical disease, and potential fundamental errors in understanding that may be leading scientific investigators in unintended directions.

Molecular Medicine for Clinicians

Barry Mendelow,Michèle Ramsay,Nanthakumarn Chetty,Wendy Stevens,Patrick Arbuthnot,Silke Arndt,Sahle Asfaha,Jacqueline Brown,Alexio Capovilla,Arnold Christianson,Gerrit Coetzee,Theresa Coetzer,Leandra Cronjé,Nigel Crowther,Chrisna Durandt,Adriano Duse,Lindsay Earlam,Debbie Glencross,Nerine Gregersen,Kate Hammond,Tabitha Haw,Nicole Holland,Penny Keene,Hendrik Koornhof,Amanda Krause,Anthony Lane,Zane Lombard,Elizabeth Mayne,Marion Munster,Grant Napier,Andries Oelofse,Lillian Ouko,Maria Papathanasopoulos,Alan Paterson,Michael Pepper,Wolfgang Prinz,Natela Rekhviashvili,Nerina Savage,Barry Schoub,Lesley Scott,Mieneke Smit van Dixhoorn,Himla Soodyall,Gwynneth Stevens,Ahmed Wadee,Sarah Walters,Marco Weinberg,Natalie Whalley,Tracey Wiggill,Pascale Willem
Molecular Medicine for Clinicians Book PDF

Author : Barry Mendelow,Michèle Ramsay,Nanthakumarn Chetty,Wendy Stevens,Patrick Arbuthnot,Silke Arndt,Sahle Asfaha,Jacqueline Brown,Alexio Capovilla,Arnold Christianson,Gerrit Coetzee,Theresa Coetzer,Leandra Cronjé,Nigel Crowther,Chrisna Durandt,Adriano Duse,Lindsay Earlam,Debbie Glencross,Nerine Gregersen,Kate Hammond,Tabitha Haw,Nicole Holland,Penny Keene,Hendrik Koornhof,Amanda Krause,Anthony Lane,Zane Lombard,Elizabeth Mayne,Marion Munster,Grant Napier,Andries Oelofse,Lillian Ouko,Maria Papathanasopoulos,Alan Paterson,Michael Pepper,Wolfgang Prinz,Natela Rekhviashvili,Nerina Savage,Barry Schoub,Lesley Scott,Mieneke Smit van Dixhoorn,Himla Soodyall,Gwynneth Stevens,Ahmed Wadee,Sarah Walters,Marco Weinberg,Natalie Whalley,Tracey Wiggill,Pascale Willem
Publisher : NYU Press
Page : 531 pages
File Size : 42,5 Mb
Release : 2008-10-01
Category : Science
ISBN : 9781868147137

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Molecular Medicine for Clinicians by Barry Mendelow,Michèle Ramsay,Nanthakumarn Chetty,Wendy Stevens,Patrick Arbuthnot,Silke Arndt,Sahle Asfaha,Jacqueline Brown,Alexio Capovilla,Arnold Christianson,Gerrit Coetzee,Theresa Coetzer,Leandra Cronjé,Nigel Crowther,Chrisna Durandt,Adriano Duse,Lindsay Earlam,Debbie Glencross,Nerine Gregersen,Kate Hammond,Tabitha Haw,Nicole Holland,Penny Keene,Hendrik Koornhof,Amanda Krause,Anthony Lane,Zane Lombard,Elizabeth Mayne,Marion Munster,Grant Napier,Andries Oelofse,Lillian Ouko,Maria Papathanasopoulos,Alan Paterson,Michael Pepper,Wolfgang Prinz,Natela Rekhviashvili,Nerina Savage,Barry Schoub,Lesley Scott,Mieneke Smit van Dixhoorn,Himla Soodyall,Gwynneth Stevens,Ahmed Wadee,Sarah Walters,Marco Weinberg,Natalie Whalley,Tracey Wiggill,Pascale Willem Pdf

This book is suitable for undergraduate medical students, as part of their basic sciences training, but is also relevant to interested under- and postgraduate science and engineering students. There is a special focus on the application of molecular medicine in Africa and in developing countries elsewhere.

Introduction to Molecular Medicine

Dennis W. Ross
Introduction to Molecular Medicine Book PDF

Author : Dennis W. Ross
Publisher : Springer Science & Business Media
Page : 180 pages
File Size : 44,6 Mb
Release : 2002-05-17
Category : Medical
ISBN : 0387953728

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Introduction to Molecular Medicine by Dennis W. Ross Pdf

Presents the discoveries, basic scientific concepts, and sense of excitement that surround the revolution in molecular medicine. The scientific basis of molecular medicine is presented simply and directly, but at a level of technical detail sufficient for the reader to appreciate the power of recombinant DNA technology. The volume is clinically oriented throughout. Annotation copyrighted by Book News, Inc., Portland, OR