Brain Receptor Methodologies Pt A General Methods And Concepts Amines And Acetylcholine

Author : Paul J. Marangos
Publisher : Elsevier
Page : 384 pages
File Size : 40,7 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323152808

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Brain Receptor Methodologies Pt A by Paul J. Marangos Pdf

Brain Receptor Methodologies, Part A, General Methods and Concepts: Amines and Acetylcholine provides information pertinent to neurotransmitter and neuromodulator receptors in brain. This book explores the methodologies that can used to address several basic and clinical problems. Organized into two sections encompassing 18 chapters, this book starts with an overview of the receptor concept, which can be validated from indirect evidence obtained in studies of the quantitative aspects of drug antagonism. This text then examines the radioligand–receptor binding interactions. Other chapters consider immunocytochemistry, which has a primary role in determining the precise distribution of regulatory peptides to neural and endocrine elements of the diffuse neuroendocrine system. The final chapter discusses the use of the radioligand binding procedure for the study of muscarinic receptors, which has expanded the area of muscarinic receptor pharmacology. Biochemists, pharmacologists, physiologists, and researchers engaged in the fields of neurobiology and neuroscience will find this book extremely useful.

Author : Paul J. Marangos,Robert M. Cohen,Iain C. Campbell
Publisher : Unknown
Page : 392 pages
File Size : 45,5 Mb
Release : 1984
Category : Brain chemistry
ISBN : UOM:39015007102760

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Brain Receptor Methodologies by Paul J. Marangos,Robert M. Cohen,Iain C. Campbell Pdf

Brain Receptor Methodologies, Part A, General Methods and Concepts: Amines and Acetylcholine provides information pertinent to neurotransmitter and neuromodulator receptors in brain. This book explores the methodologies that can used to address several basic and clinical problems. Organized into two sections encompassing 18 chapters, this book starts with an overview of the receptor concept, which can be validated from indirect evidence obtained in studies of the quantitative aspects of drug antagonism. This text then examines the radioligand-receptor binding interactions. Other chapters consi ...

Author : Paul J. Marangos,Iain C. Campbell,Robert M. Cohen
Publisher : Unknown
Page : 128 pages
File Size : 52,6 Mb
Release : 1984
Category : Electronic
ISBN : 012470350X

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Brain Receptor Methodologies by Paul J. Marangos,Iain C. Campbell,Robert M. Cohen Pdf

Author : Paul J. Marangos,Iain C. Campbell,Robert M. Cohen
Publisher : Unknown
Page : 368 pages
File Size : 53,9 Mb
Release : 1984
Category : Brain chemistry
ISBN : UOM:39015007082921

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Brain Receptor Methodologies: pt. A. General methods and concepts. Amines and acetylcholine by Paul J. Marangos,Iain C. Campbell,Robert M. Cohen Pdf

Author : Anonim
Publisher : Elsevier
Page : 553 pages
File Size : 41,7 Mb
Release : 1988-07-01
Category : Medical
ISBN : 9780080861982

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Biochemical Basis of Functional Neuroteratology by Anonim Pdf

Biochemical Basis of Functional Neuroteratology

Author : Jr. Ruffolo
Publisher : Springer Science & Business Media
Page : 548 pages
File Size : 53,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461245827

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The alpha-1 Adrenergic Receptors by Jr. Ruffolo Pdf

During the past decade, great strides have been made in our un derstanding of the biochemistry and pharmacology of the alpha-l adrenergic receptor. The alpha-l adrenergic receptor plays a key role in biological function. This is evidenced by the fact that the alpha-l adrenergic receptor plays a prominent functional role in most organs of the body and in the key systems responsible for survival of the organism and maintenance of optimum biological activity. This is most apparent in the cardiovascular system, in which alpha-l adrenergic receptors are the single most important receptor involved in the maintenance of blood pressure and circu latory function. It is appropriate, therefore, that recent findings related to the pharmacology and biochemistry of the alpha-l adrenergic receptor be compiled, since this subject has not been reviewed in detail in recent years. It is the purpose of this book to present a series of reviews of key experimental findings that shed new light on the alpha-l adrenergic receptor and the manner in which it functions. Classically, most receptors have been characterized based on structure-activity relationships obtained for selective agonists and antagonists interacting with the receptor. Although there are many newer and more sophisticated approaches to receptor char acterization, structure-activity relationships still provide impor tant information regarding the chemical requirements made by the receptor for its occupation by ligands and its subsequent acti vation by those ligands possessing intrinsic efficacy and, there fore, agonist activity.

Author : Paul Marangos
Publisher : Elsevier
Page : 411 pages
File Size : 43,5 Mb
Release : 2012-12-02
Category : Nature
ISBN : 9780323151566

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Neuronal and Glial Proteins by Paul Marangos Pdf

Neuronal and Glial Proteins: Structure, Function, and Clinical Application focuses on the basic and clinical information relating to a number of proteins that are either enriched in or unique to nervous tissue. This book discusses the structural and functional characteristics of cell-specific proteins, which provide a better understanding of the molecular mechanisms involved in processes that are specific to glia or neurons. Organized into three sections encompassing 15 chapters, this book starts with an overview of the fundamental principles and strategies involved in studying the anatomical, structural, functional, and immunological aspects of brain protein. This text then discusses the techniques, including the preparation of brain tissues as well as the preparation of neural and glial cells in purified form. Other chapters review the two-dimensional gel electrophoresis, which is recognized as a significant technique for discovering brain molecules. The final chapter deals with the membrane-associated nervous system proteins. Neurochemists and clinical researchers will find this book useful.

Author : Paul J. Marangos,Iain C. Campbell,Robert M. Cohen
Publisher : Academic Press
Page : 357 pages
File Size : 54,7 Mb
Release : 2013-10-22
Category : Nature
ISBN : 9781483269597

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Brain Receptor Methodologies by Paul J. Marangos,Iain C. Campbell,Robert M. Cohen Pdf

Brain Receptor Methodologies: Part B Amino Acids. Peptides. Psychoactive Drugs is the second of the two-part first volume of the Neurobiological Research series, which provides a comprehensive view of various subdisciplines within neurobiology. The first volume (Parts A and B) deals with the area of neurotransmitter and neuromodulator receptors in brain; future volumes will cover the subdisciplines of neuroanatomy, neurophysiology, brain-specific macromolecules, neurochemistry, and behavioral neurobiology. It is hoped that the series will be of equal value for both basic as well as clinical scientists Part B continues from Part A with the remainder of Section II, specific receptor binding methodologies. Subsection II,B deals with receptors for amino acids and neuropeptides and covers areas including GABA, glycine, carnosine, opiates, bombesin, CCK, TRH, and substance P. Amino acids probably represent the majority of brain neurotransmitter substances, at least relative to the amines and acetylcholine, although with the exception of GABA, the amino acids remain relatively uncharacterized in brain. Their further study should receive high priority.

Author : Y. Mishima
Publisher : Springer Science & Business Media
Page : 893 pages
File Size : 40,6 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781475795677

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Cancer Neutron Capture Therapy by Y. Mishima Pdf

There are many human cancers which actively synthesize specific characteristic proteins such as melanomas, thyroid cancer and squamous cell carcinoma. Many cancer researchers have of course tried to utilize this specific activity as a key for the selective treatment of cancers. In the past for example, the molecular hybrid compound of DOPA, a substrate of melanin, and nitrogen mustard N-oxide hydrochloride, a ctyotoxic anti-tumor drug, was synthesized as Melphalan and used to treat malignant melanoma. A major problem arose though in that it was soon found to be highly suppressive toward bone marrow and quite toxic while not being remarkably effective. Thus, malignant melanoma could not be cured by it. Such failure led us to develop a novel bimodal therapeutic system which includes the use of non-toxic potentially cytocidal chemicals which selectively accumulate within the cancer cells and which are converted by a controllable modality into an actively cytocidal element in situ. We can now non-surgically cure malignant melanoma and glioblastoma with our selective cancer treatment, neutron capture therapy (NCT); as can be found in this volume. Included are 124 papers on the latest breaking developments discussed at the Sixth International Symposium on NCT for Cancer held in Kobe during the late autumn of 1994.

Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 1736 pages
File Size : 48,7 Mb
Release : 2024-07-01
Category : Medicine
ISBN : STANFORD:36105009872693

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Current Catalog by National Library of Medicine (U.S.) Pdf

Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 1728 pages
File Size : 53,8 Mb
Release : 1985
Category : Medicine
ISBN : MINN:31951M013754299

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National Library of Medicine Current Catalog by National Library of Medicine (U.S.) Pdf

Author : Dr. John Wharton,Julia M. Polak
Publisher : Unknown
Page : 382 pages
File Size : 44,8 Mb
Release : 1993
Category : Medical
ISBN : UOM:39015032570932

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Receptor Autoradiography by Dr. John Wharton,Julia M. Polak Pdf

Receptor autoradiography is an invaluable technique that is widely used to localize and characterize peptide and neurotransmitter binding sites. Its extensive use reflects the utility of the technique and the important advantages it offers over conventional biochemical procedures. This instructive work makes receptor autoradiography more accessible by giving a detailed account of the methodology and its application in the analysis of receptors in the brain and peripheral organs. These examples are not exhaustive but illustrate the versatility of the technique as well as its potential pitfalls. The book provides an introduction to the receptor concept and gives detailed information on the theory and procedures involved in the autoradiographic localization and quantification of radiolabelled ligand binding sites. This volume will be an essential tool for neuroscientists, pharmacologists, histochemists, neuropathologists, researchers in the pharmaceutical industry, and students of the biological sciences.

Author : Anonim
Publisher : Unknown
Page : 818 pages
File Size : 42,9 Mb
Release : 1986
Category : Neurobiology
ISBN : UCAL:B5031017

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Journal of Neurobiology by Anonim Pdf

Author : Anonim
Publisher : Unknown
Page : 466 pages
File Size : 49,8 Mb
Release : 1985
Category : Nervous system
ISBN : UCSD:31822017955378

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Journal Canadien Des Sciences Neurologiques by Anonim Pdf

Author : Frances M. Leslie,C. Anthony Altar
Publisher : Unknown
Page : 248 pages
File Size : 50,8 Mb
Release : 1988
Category : Autoradiography
ISBN : UOM:39015015062816

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Receptor Localization by Frances M. Leslie,C. Anthony Altar Pdf