Epigenetics In Human Reproduction And Development

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Epigenetics In Human Reproduction And Development

Naumova Anna K,Taketo-hosotani Teruko
Epigenetics In Human Reproduction And Development Book PDF

Author : Naumova Anna K,Taketo-hosotani Teruko
Publisher : World Scientific
Page : 304 pages
File Size : 42,6 Mb
Release : 2016-12-20
Category : Medical
ISBN : 9789813144286

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Epigenetics In Human Reproduction And Development by Naumova Anna K,Taketo-hosotani Teruko Pdf

Epigenetics is defined as heritable changes that do not affect the DNA sequence but influence gene expression. Epigenetic changes occur at the levels of DNA, histone, protein, and chromatin structures. Proper epigenetic modifications are essential for cell differentiation and function during development, while some epigenetic modifications are passed on from parents to offspring through gametes. Therefore, alterations of epigenetic states would have serious consequences for human development and health. This realization and the advent of new technologies have encouraged the advance of epigenetic studies in recent years. Nonetheless, many aspects of epigenetics, such as regulatory mechanisms and evolutional advantages, remain to be better understood. Written by 26 scientists at the forefront of epigenetics research, this book discusses the different facets of epigenetics: from gametogenesis to child development, as well as from mechanistic studies in animal models to reviews of human clinical data.

Epigenetics in Human Reproduction and Development

Anna K. Naumova,Teruko Taketo
Epigenetics in Human Reproduction and Development Book PDF

Author : Anna K. Naumova,Teruko Taketo
Publisher : Unknown
Page : 304 pages
File Size : 49,9 Mb
Release : 2016
Category : HEALTH & FITNESS
ISBN : 9813144270

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Epigenetics in Human Reproduction and Development by Anna K. Naumova,Teruko Taketo Pdf

"Epigenetics is defined as heritable changes that do not affect the DNA sequence but influence gene expression. Epigenetic changes occur at the levels of DNA, histone, protein, and chromatin structures. Proper epigenetic modifications are essential for cell differentiation and function during development, while some epigenetic modifications are passed on from parents to offspring through gametes. Therefore, alterations of epigenetic states would have serious consequences for human development and health. This realization and the advent of new technologies have encouraged the advance of epigenetic studies in recent years. Nonetheless, many aspects of epigenetics, such as regulatory mechanisms and evolutional advantages, remain to be better understood. Written by 26 scientists at the forefront of epigenetics research, this book discusses the different facets of epigenetics: from gametogenesis to child development, as well as from mechanistic studies in animal models to reviews of human clinical data."--Publisher's website.

Epigenetics and Human Reproduction

Sophie Rousseaux,Saadi Khochbin
Epigenetics and Human Reproduction Book PDF

Author : Sophie Rousseaux,Saadi Khochbin
Publisher : Springer Science & Business Media
Page : 372 pages
File Size : 46,8 Mb
Release : 2010-11-03
Category : Medical
ISBN : 9783642147739

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Epigenetics and Human Reproduction by Sophie Rousseaux,Saadi Khochbin Pdf

Epigenetics is a rapidly expanding field in medical and biological research which concerns heritable traits that are not attributable to changes in the DNA sequence. Epigenetic mechanisms play key roles in many biological processes, and it has become clear that their disruption can gives rise to diverse pathologies in humans. Edited by preeminent experts, Sophie Rousseaux and Saadi Khochbin, this volume in the ‘Epigenetics and Human Health’ series discusses the role of epigenetics in human reproduction

Epigenetics and Human Reproduction

Sophie Rousseaux,Saadi Khochbin
Epigenetics and Human Reproduction Book PDF

Author : Sophie Rousseaux,Saadi Khochbin
Publisher : Springer
Page : 372 pages
File Size : 45,5 Mb
Release : 2010-11-05
Category : Medical
ISBN : 3642147720

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Epigenetics and Human Reproduction by Sophie Rousseaux,Saadi Khochbin Pdf

Epigenetics is a rapidly expanding field in medical and biological research which concerns heritable traits that are not attributable to changes in the DNA sequence. Epigenetic mechanisms play key roles in many biological processes, and it has become clear that their disruption can gives rise to diverse pathologies in humans. Edited by preeminent experts, Sophie Rousseaux and Saadi Khochbin, this volume in the ‘Epigenetics and Human Health’ series discusses the role of epigenetics in human reproduction

Epigenetics and Reproductive Health

Anonim
Epigenetics and Reproductive Health Book PDF

Author : Anonim
Publisher : Academic Press
Page : 464 pages
File Size : 54,5 Mb
Release : 2020-09-12
Category : Medical
ISBN : 9780128197547

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Epigenetics and Reproductive Health by Anonim Pdf

Epigenetics and Reproductive Health, a new volume in the Translational Epigenetics series, provides a thorough overview and discussion of epigenetics in reproduction and implications for reproductive medicine. Twenty international researchers discuss epigenetic mechanisms operating during the formation of male and female gametes, fertilization and subsequent embryo and placental development, particularly in mammals and transgenerational epigenetic inheritance. This volume also addresses aberrant epigenetic changes influencing male and female infertility, pregnancy related disorders, and those potentially linked to therapeutic manipulations and assisted reproductive technologies. Emphasis is placed on identifying biomarkers for early detection of aberrant epigenetic mechanisms. Later chapters examine the possibility of correcting these epigenetic dysfunctions, as well as current challenges and next steps in research, enabling new translational discoveries and efforts towards developing therapeutics. Thoroughly examines the influence of aberrant epigenetics during gametogenesis and embryogenesis, affecting parents, gametes and embryos, offspring and future generations Explores health outcomes for reproductive senescence, endocrine disruption, testicular cancer, prostrate cancer, breast cancer, ovarian, cancer, endometrial cancer and cervical cancers Features chapter contributions from international researchers in the field

Epigenetics and Epigenomics

Christopher J. Payne
Epigenetics and Epigenomics Book PDF

Author : Christopher J. Payne
Publisher : BoD – Books on Demand
Page : 222 pages
File Size : 54,8 Mb
Release : 2014-04-29
Category : Medical
ISBN : 9789535113638

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Epigenetics and Epigenomics by Christopher J. Payne Pdf

The book aims to provide an overview of current knowledge regarding epigenetics and epigenomics. Included are reviews on the role of epigenetics in the development and pathogenesis of the vascular endothelium and nervous system, as well as our current understanding of the potential etiologies of Autism Spectrum Disorders. Additional chapters are devoted to DNA methylation, genomic imprinting and human reproduction. A discussion of the role of the epigenome in cancer prevention and polyphenols is also included. Authors provide research findings from both human data and animal model studies. This book will be of interest to scientists, physicians and lay readers wishing to review recent developments in the field of epigenetics and epigenomics.

Textbook of Human Reproductive Genetics

Stéphane Viville,Karen D. Sermon
Textbook of Human Reproductive Genetics Book PDF

Author : Stéphane Viville,Karen D. Sermon
Publisher : Cambridge University Press
Page : 255 pages
File Size : 42,6 Mb
Release : 2022-12-31
Category : Medical
ISBN : 9781009197724

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Textbook of Human Reproductive Genetics by Stéphane Viville,Karen D. Sermon Pdf

This book combines genetics, reproductive biology and medicine for an integrative view of the emerging specialism of reproductive genetics.

Epigenetics and Assisted Reproduction

Cristina Camprubí,Joan Blanco
Epigenetics and Assisted Reproduction Book PDF

Author : Cristina Camprubí,Joan Blanco
Publisher : CRC Press
Page : 330 pages
File Size : 40,8 Mb
Release : 2018-09-03
Category : Medical
ISBN : 9781351804448

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Epigenetics and Assisted Reproduction by Cristina Camprubí,Joan Blanco Pdf

Epigenetics is the study of how certain genes are activated without modification at the DNA sequence level, resulting in genetically similar individuals having different clinical outcomes. As contemporary medicine increasingly aims to personalize the medical approach to a patient's genetic profile, the factors that can affect which genes are expressed also increase in importance and relevance to the clinician. This text from experts will give the clinician in Reproductive Medicine a reliable grounding in current thinking and research on this fast-moving topic, with many clinical implications.

Genetics of Human Infertility

P.H. Vogt
Genetics of Human Infertility Book PDF

Author : P.H. Vogt
Publisher : Karger Medical and Scientific Publishers
Page : 178 pages
File Size : 40,9 Mb
Release : 2017-09-12
Category : Medical
ISBN : 9783318060980

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Genetics of Human Infertility by P.H. Vogt Pdf

Infertility affects more than one in ten couples worldwide and is related to highly heterogeneous pathologies sometimes only discernible in the germ line. Its complex etiology often, but not always, includes genetic factors besides anatomical defects, immunological interference, and environmental aspects. Nearly 30% of infertility cases are probably caused only by genetic defects. Thereby experimental animal knockout models convincingly show that infertility can be caused by single or multiple gene defects. Translating those basic research findings into clinical studies is challenging, leaving genetic causes for the vast majority of infertility patients unexplained. Nevertheless, a large number of candidate genes have been revealed by sophisticated molecular methods. This book provides a comprehensive overview on the subject of infertility written by the leading authorities in this field. It covers topics including basic biological, cytological, and molecular studies, as well as common and uncommon syndromes. It is a must-read for human geneticists, endocrinologists, epidemiologists, zoologists, and counsellors in human genetics, infertility, and assisted reproduction.

Sperm Chromatin

Armand Zini,Ashok Agarwal
Sperm Chromatin Book PDF

Author : Armand Zini,Ashok Agarwal
Publisher : Springer Science & Business Media
Page : 512 pages
File Size : 52,5 Mb
Release : 2011-08-04
Category : Health & Fitness
ISBN : 1441968571

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Sperm Chromatin by Armand Zini,Ashok Agarwal Pdf

Sperm DNA damage is common and has been associated with reduced rates of conception, impaired embryonic development and increased risk of miscarriage. Although the exact causes of sperm DNA damage are unknown, it is clear that infertile men possess substantially higher levels of sperm DNA damage than do fertile men. Written by leading, internationally renowned clinicians and basic scientists with expertise in sperm DNA, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction provides readers with a thoughtful and comprehensive review of the biological and clinical significance of sperm DNA damage. The work covers the fundamental principles of sperm chromatin architecture and function, the proposed modes of DNA damage and repair, the tests of sperm DNA damage, the clinical aspects of DNA damage and the impact of DNA damage on reproductive outcome. Unlike any other title on the topic, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction is an invaluable addition to the literature and will serve as an indispensable resource for basic scientists with an interest in sperm biology and for urologists, gynecologists, reproductive endocrinologists, and embryologists working in the field of infertility.

Animal Models and Human Reproduction

Heide Schatten,Gheorghe M. Constantinescu
Animal Models and Human Reproduction Book PDF

Author : Heide Schatten,Gheorghe M. Constantinescu
Publisher : John Wiley & Sons
Page : 600 pages
File Size : 42,8 Mb
Release : 2017-01-12
Category : Science
ISBN : 9781118881422

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Animal Models and Human Reproduction by Heide Schatten,Gheorghe M. Constantinescu Pdf

Our knowledge of reproductive biology has increased enormously in recent years on cellular, molecular, and genetic levels, leading to significant breakthroughs that have directly benefitted in vitro fertilization (IVF) and other assisted reproductive technologies (ART) in humans and animal systems. Animal Models and Human Reproduction presents a comprehensive reference that reflects the latest scientific research being done in human reproductive biology utilizing domestic animal models. Chapters on canine, equine, cow, pig, frog, and mouse models of reproduction reflect frontier research in placental biology, ovarian function and fertility, non-coding RNAs in gametogenesis, oocyte and embryo metabolism, fertilization, cryopreservation, signal transduction pathways, chromatin dynamics, epigenetics, reproductive aging, and inflammation. Chapters on non-human primate models also highlight recent advancements into such issues as human in vitro fertilization (IVF) and assisted reproductive technologies (ART). This book offers animal scientists, reproductive biology scientists, clinicians and practitioners, invaluable insights into a wide range of issues at the forefront of human reproductive health.

The Epigenetics Revolution

Nessa Carey
The Epigenetics Revolution Book PDF

Author : Nessa Carey
Publisher : Columbia University Press
Page : 353 pages
File Size : 42,9 Mb
Release : 2012-03-06
Category : Science
ISBN : 9780231530712

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The Epigenetics Revolution by Nessa Carey Pdf

Epigenetics can potentially revolutionize our understanding of the structure and behavior of biological life on Earth. It explains why mapping an organism's genetic code is not enough to determine how it develops or acts and shows how nurture combines with nature to engineer biological diversity. Surveying the twenty-year history of the field while also highlighting its latest findings and innovations, this volume provides a readily understandable introduction to the foundations of epigenetics. Nessa Carey, a leading epigenetics researcher, connects the field's arguments to such diverse phenomena as how ants and queen bees control their colonies; why tortoiseshell cats are always female; why some plants need cold weather before they can flower; and how our bodies age and develop disease. Reaching beyond biology, epigenetics now informs work on drug addiction, the long-term effects of famine, and the physical and psychological consequences of childhood trauma. Carey concludes with a discussion of the future directions for this research and its ability to improve human health and well-being.

The Genetics of Male Infertility

Douglas T. Carrell
The Genetics of Male Infertility Book PDF

Author : Douglas T. Carrell
Publisher : Springer Science & Business Media
Page : 337 pages
File Size : 43,7 Mb
Release : 2007-11-08
Category : Medical
ISBN : 9781597451765

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The Genetics of Male Infertility by Douglas T. Carrell Pdf

In this book, twenty-one researchers and clinicians review the study of the genetics of male infertility, the tools available in the laboratory and clinic, the current state of knowledge, and the future of research and translation into clinical diagnostics and treatments. New tools discussed are discussed. This book therefore serves as a guide to evidence-based clinical applications, and a preview of future possibilities.

Environmental Epigenetics

L. Joseph Su,Tung-chin Chiang
Environmental Epigenetics Book PDF

Author : L. Joseph Su,Tung-chin Chiang
Publisher : Springer
Page : 321 pages
File Size : 46,8 Mb
Release : 2015-05-18
Category : Medical
ISBN : 9781447166788

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Environmental Epigenetics by L. Joseph Su,Tung-chin Chiang Pdf

This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Introduction to Epigenetics

Renato Paro,Ueli Grossniklaus,Raffaella Santoro,Anton Wutz
Introduction to Epigenetics Book PDF

Author : Renato Paro,Ueli Grossniklaus,Raffaella Santoro,Anton Wutz
Publisher : Springer Nature
Page : 215 pages
File Size : 46,7 Mb
Release : 2021-03-23
Category : Science
ISBN : 9783030686703

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Introduction to Epigenetics by Renato Paro,Ueli Grossniklaus,Raffaella Santoro,Anton Wutz Pdf

This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease