Epigenetics And Assisted Reproduction

Author : Cristina Camprubí,Joan Blanco
Publisher : CRC Press
Page : 330 pages
File Size : 51,9 Mb
Release : 2018-09-03
Category : Medical
ISBN : 9781351804448

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Epigenetics and Assisted Reproduction by Cristina Camprubí,Joan Blanco Pdf

Epigenetics is the study of how certain genes are activated without modification at the DNA sequence level, resulting in genetically similar individuals having different clinical outcomes. As contemporary medicine increasingly aims to personalize the medical approach to a patient's genetic profile, the factors that can affect which genes are expressed also increase in importance and relevance to the clinician. This text from experts will give the clinician in Reproductive Medicine a reliable grounding in current thinking and research on this fast-moving topic, with many clinical implications.

Author : Sophie Rousseaux,Saadi Khochbin
Publisher : Springer Science & Business Media
Page : 372 pages
File Size : 43,8 Mb
Release : 2010-11-03
Category : Medical
ISBN : 9783642147739

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Epigenetics and Human Reproduction by Sophie Rousseaux,Saadi Khochbin Pdf

Epigenetics is a rapidly expanding field in medical and biological research which concerns heritable traits that are not attributable to changes in the DNA sequence. Epigenetic mechanisms play key roles in many biological processes, and it has become clear that their disruption can gives rise to diverse pathologies in humans. Edited by preeminent experts, Sophie Rousseaux and Saadi Khochbin, this volume in the ‘Epigenetics and Human Health’ series discusses the role of epigenetics in human reproduction

Author : Anonim
Publisher : Academic Press
Page : 464 pages
File Size : 49,7 Mb
Release : 2020-09-12
Category : Medical
ISBN : 9780128197547

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Epigenetics and Reproductive Health by Anonim Pdf

Epigenetics and Reproductive Health, a new volume in the Translational Epigenetics series, provides a thorough overview and discussion of epigenetics in reproduction and implications for reproductive medicine. Twenty international researchers discuss epigenetic mechanisms operating during the formation of male and female gametes, fertilization and subsequent embryo and placental development, particularly in mammals and transgenerational epigenetic inheritance. This volume also addresses aberrant epigenetic changes influencing male and female infertility, pregnancy related disorders, and those potentially linked to therapeutic manipulations and assisted reproductive technologies. Emphasis is placed on identifying biomarkers for early detection of aberrant epigenetic mechanisms. Later chapters examine the possibility of correcting these epigenetic dysfunctions, as well as current challenges and next steps in research, enabling new translational discoveries and efforts towards developing therapeutics. Thoroughly examines the influence of aberrant epigenetics during gametogenesis and embryogenesis, affecting parents, gametes and embryos, offspring and future generations Explores health outcomes for reproductive senescence, endocrine disruption, testicular cancer, prostrate cancer, breast cancer, ovarian, cancer, endometrial cancer and cervical cancers Features chapter contributions from international researchers in the field

Author : Windsor Epigenetics Study Group
Publisher : University of Windsor
Page : 338 pages
File Size : 49,9 Mb
Release : 2015-10-26
Category : Science
ISBN : 9780920233726

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Epigenetics in Society by Windsor Epigenetics Study Group Pdf

This is a book written by students of diverse disciplines, and intended for students and educated lay people. We intend this book to serve several functions. First, we want to make the field of epigenetics accessible to lay readers. Second, and more importantly, we want to excite further interest and concern regarding the social, ethical, legal, health, and policy implications that this field will have for all arenas of our lives. Third, we want to arm our readers with knowledge and wariness so that they can understand and critique the nuanced debates that will inevitably arise when costs and benefits must be weighed: while the effects of epigenetics upon us as individuals may be subtle, the demographic implications and costs are huge.

Author : Stéphane Viville,Karen D. Sermon
Publisher : Cambridge University Press
Page : 255 pages
File Size : 45,5 Mb
Release : 2022-12-31
Category : Medical
ISBN : 9781009197724

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Textbook of Human Reproductive Genetics by Stéphane Viville,Karen D. Sermon Pdf

This book combines genetics, reproductive biology and medicine for an integrative view of the emerging specialism of reproductive genetics.

Author : Sophie Rousseaux,Saadi Khochbin
Publisher : Springer
Page : 372 pages
File Size : 42,8 Mb
Release : 2010-11-05
Category : Medical
ISBN : 3642147720

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Epigenetics and Human Reproduction by Sophie Rousseaux,Saadi Khochbin Pdf

Epigenetics is a rapidly expanding field in medical and biological research which concerns heritable traits that are not attributable to changes in the DNA sequence. Epigenetic mechanisms play key roles in many biological processes, and it has become clear that their disruption can gives rise to diverse pathologies in humans. Edited by preeminent experts, Sophie Rousseaux and Saadi Khochbin, this volume in the ‘Epigenetics and Human Health’ series discusses the role of epigenetics in human reproduction

Author : Naumova Anna K,Taketo-hosotani Teruko
Publisher : World Scientific
Page : 304 pages
File Size : 46,5 Mb
Release : 2016-12-20
Category : Medical
ISBN : 9789813144286

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Epigenetics In Human Reproduction And Development by Naumova Anna K,Taketo-hosotani Teruko Pdf

Epigenetics is defined as heritable changes that do not affect the DNA sequence but influence gene expression. Epigenetic changes occur at the levels of DNA, histone, protein, and chromatin structures. Proper epigenetic modifications are essential for cell differentiation and function during development, while some epigenetic modifications are passed on from parents to offspring through gametes. Therefore, alterations of epigenetic states would have serious consequences for human development and health. This realization and the advent of new technologies have encouraged the advance of epigenetic studies in recent years. Nonetheless, many aspects of epigenetics, such as regulatory mechanisms and evolutional advantages, remain to be better understood. Written by 26 scientists at the forefront of epigenetics research, this book discusses the different facets of epigenetics: from gametogenesis to child development, as well as from mechanistic studies in animal models to reviews of human clinical data.

Author : Marianne Legato J,Dov Feldberg,Marek Glezerman
Publisher : Elsevier
Page : 316 pages
File Size : 41,7 Mb
Release : 2023-05-23
Category : Medical
ISBN : 9780128239384

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Sex, Gender, and Epigenetics by Marianne Legato J,Dov Feldberg,Marek Glezerman Pdf

Sex, Gender, and Epigenetics: From Molecule to Bedside explores our expanding knowledge of the science of epigenetics in which gene expression is modified as a consequence of small chemical additions to various components of the genome. The book provides an overview of the field, describing the epigenetic phenomena that unite biological sex and environmental experience to create the unique phenome of each individual. The book also analyzes the impact of ancestors’ environmental experience on subsequent generations through the sex-specific transmission of environmentally induced epigenetic modifications. Here, international leaders in the field discuss both sex-specific normal physiology and the experience of disease, with chapters dedicated to fetal programming, the microbiome, cancer, bipolar disorder and schizophrenia, embryogenesis, and oocyte aging, among other topics. Examines the impact of biological sex and gender on gene expression through epigenetic mechanisms, and its relationship to human biology and disease Presents the current state of our understanding of how environmental experience is translated to future generations in a sex specific manner Features chapter contributions from international leaders in the field

Author : Aurora Brooks
Publisher : BabyDreamers.net
Page : 47 pages
File Size : 48,7 Mb
Release : 101-01-01
Category : Health & Fitness
ISBN : 9781991093882

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The Role of Genetics in Fertility by Aurora Brooks Pdf

Introducing "The Role of Genetics in Fertility: Exploring the Link Between Genetics and Reproductive Health" Are you curious about the role genetics play in fertility? Do you want to understand how genetic disorders can impact your ability to conceive? Look no further than "The Role of Genetics in Fertility: Exploring the Link Between Genetics and Reproductive Health." This short read book delves into the fascinating world of genetics and its influence on fertility, providing valuable insights and information for anyone interested in reproductive health. Table of Contents: 1. Genetic Disorders and Infertility: Discover how genetic disorders can affect fertility and what steps can be taken to overcome these challenges. 2. Genetic Testing for Fertility: Learn about the various genetic tests available to assess fertility potential and identify any underlying genetic issues. 3. Preimplantation Genetic Testing: Explore the revolutionary technique of preimplantation genetic testing and its role in selecting embryos with the highest chance of successful implantation. 4. Genetic Markers for Fertility: Uncover the genetic markers associated with fertility and how they can be used to predict reproductive success. 5. Genetic Counseling for Infertility: Understand the importance of genetic counseling in helping individuals and couples make informed decisions about their fertility journey. 6. Epigenetics and Fertility: Delve into the field of epigenetics and its impact on fertility, including how epigenetic changes can affect assisted reproduction techniques. 7. Epigenetic Inheritance and Fertility: Learn about the potential inheritance of epigenetic changes and its implications for future generations. 8. Genetic Factors in Age-Related Infertility: Explore the genetic factors that contribute to age-related infertility in both men and women. 9. Genetic Clock and Female Fertility: Gain insights into the concept of the genetic clock and its role in female fertility decline. 10. Genetic Factors in Male Age-related Infertility: Discover how genetic factors can affect male fertility as they age. 11. Genetic Disorders and Assisted Reproduction: Understand the challenges and considerations when using assisted reproduction techniques in individuals with genetic disorders. 12. Preimplantation Genetic Diagnosis for Genetic Disorders: Learn about the process of preimplantation genetic diagnosis and its role in preventing the transmission of genetic disorders. 13. Genetic Counseling for Assisted Reproduction: Explore the importance of genetic counseling in assisted reproduction to ensure the best possible outcomes. 14. Genetic Variability and Fertility: Discover the significance of genetic variability in fertility and its impact on reproductive success. This title is a short read. A Short Read is a type of book that is designed to be read in one quick sitting. These no fluff books are perfect for people who want an overview about a subject in a short period of time. Table of Contents The Role of Genetics in Fertility Genetic Disorders and Infertility Genetic Testing for Fertility Preimplantation Genetic Testing Genetic Markers for Fertility Genetic Counseling for Infertility Epigenetics and Fertility Epigenetic Changes and Assisted Reproduction Epigenetic Inheritance and Fertility Genetic Factors in Age-Related Infertility Genetic Clock and Female Fertility Genetic Factors in Male Age-related Infertility Genetic Disorders and Assisted Reproduction Preimplantation Genetic Diagnosis for Genetic Disorders Genetic Counseling for Assisted Reproduction Genetic Variability and Fertility Genetic Diversity and Fertility Genetic Compatibility and Reproductive Success Gene Therapy and Fertility Gene Editing for Infertility Gene Therapy for Reproductive Disorders Personalized Medicine and Fertility Genetic Biomarkers for Treatment Response Pharmacogenetics in Fertility Treatments Ethical Considerations in Genetic Fertility Research Genetic Privacy and Confidentiality Genetic Discrimination and Reproductive Choices Future Directions in Genetic Fertility Research Frequently Asked Questions

Author : Juan A. Garcia-Velasco,Emre Seli
Publisher : Academic Press
Page : 342 pages
File Size : 52,7 Mb
Release : 2020-04-19
Category : Medical
ISBN : 9780128167496

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Human Reproductive Genetics by Juan A. Garcia-Velasco,Emre Seli Pdf

Human Reproductive Genetics: Emerging Technologies and Clinical Applications presents a great reference for clinicians and researchers in reproductive medicine. Part I includes a brief background of genetics and epigenetics, probability of disease, and the different techniques that are being used today for analysis and genetic counseling. Part II focuses on the analysis of the embryo, current controversies and future concepts. Part III comprises different clinical scenarios that clinicians frequently face in practice. The increasing amount of genetic tests available and the growing information that patients handle makes this section a relevant part of the fertility treatment discussion. Finally, Part IV concludes with the psychological aspects of genetic counseling and the role of counselor and bioethics in human reproduction. Provides an essential reference for clinicians involved in reproductive medicine Builds foundational knowledge on new genetic tests coming into the clinical scenario for physicians involved with patients Assembles critically evaluated chapters that cover basic concepts of genetics and epigenetics and the techniques involved, including preimplantation genetic testing, controversies, and more

Author : P.H. Vogt
Publisher : Karger Medical and Scientific Publishers
Page : 178 pages
File Size : 49,8 Mb
Release : 2017-09-12
Category : Medical
ISBN : 9783318060980

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Genetics of Human Infertility by P.H. Vogt Pdf

Infertility affects more than one in ten couples worldwide and is related to highly heterogeneous pathologies sometimes only discernible in the germ line. Its complex etiology often, but not always, includes genetic factors besides anatomical defects, immunological interference, and environmental aspects. Nearly 30% of infertility cases are probably caused only by genetic defects. Thereby experimental animal knockout models convincingly show that infertility can be caused by single or multiple gene defects. Translating those basic research findings into clinical studies is challenging, leaving genetic causes for the vast majority of infertility patients unexplained. Nevertheless, a large number of candidate genes have been revealed by sophisticated molecular methods. This book provides a comprehensive overview on the subject of infertility written by the leading authorities in this field. It covers topics including basic biological, cytological, and molecular studies, as well as common and uncommon syndromes. It is a must-read for human geneticists, endocrinologists, epidemiologists, zoologists, and counsellors in human genetics, infertility, and assisted reproduction.

Author : Armand Zini,Ashok Agarwal
Publisher : Springer Science & Business Media
Page : 512 pages
File Size : 48,7 Mb
Release : 2011-08-04
Category : Health & Fitness
ISBN : 1441968571

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Sperm Chromatin by Armand Zini,Ashok Agarwal Pdf

Sperm DNA damage is common and has been associated with reduced rates of conception, impaired embryonic development and increased risk of miscarriage. Although the exact causes of sperm DNA damage are unknown, it is clear that infertile men possess substantially higher levels of sperm DNA damage than do fertile men. Written by leading, internationally renowned clinicians and basic scientists with expertise in sperm DNA, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction provides readers with a thoughtful and comprehensive review of the biological and clinical significance of sperm DNA damage. The work covers the fundamental principles of sperm chromatin architecture and function, the proposed modes of DNA damage and repair, the tests of sperm DNA damage, the clinical aspects of DNA damage and the impact of DNA damage on reproductive outcome. Unlike any other title on the topic, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction is an invaluable addition to the literature and will serve as an indispensable resource for basic scientists with an interest in sperm biology and for urologists, gynecologists, reproductive endocrinologists, and embryologists working in the field of infertility.

Author : Institute of Medicine,Food and Nutrition Board
Publisher : National Academies Press
Page : 170 pages
File Size : 50,5 Mb
Release : 2015-09-08
Category : Medical
ISBN : 9780309376983

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Examining a Developmental Approach to Childhood Obesity by Institute of Medicine,Food and Nutrition Board Pdf

Recent scientific evidence points to the origins of childhood obesity as an outcome of the dynamic interplay of genetic, behavioral, and environmental factors throughout early development, with a compelling body of evidence suggesting that both maternal and paternal nutritional and other exposures affect a child's risk of later obesity. The burgeoning field of epigenetics has led researchers to speculate that many of the observed associations between early developmental exposures and later risk of childhood obesity are mediated, at least in part, through epigenetic mechanisms. To explore the body of evolving science that examines the nexus of biology, environment, and developmental stage on risk of childhood obesity, the Institute of Medicine and the National Research Council convened a workshop in February 2015. The workshop focused on the prenatal period, infancy, and early childhood and addressed evidence from both animal and human studies. Workshop objectives were to (1) identify epigenetic-mediated relationships between exposure to risk factors during sensitive periods of development (gestation through age 3) and subsequent obesity-related outcomes; (2) explore the science around periods of plasticity and potential reversibility of obesity risk in the context of early childhood development; and (3) examine the translation of epigenetic science to guide early childhood obesity prevention and intervention to reduce obesity risk. This report summarizes the information presented and discussed at the workshop.

Author : Nidhi Sharma,Sudakshina Chakrabarti,Yona Barak,Adrian Ellenbogen
Publisher : Unknown
Page : 128 pages
File Size : 52,6 Mb
Release : 2020
Category : Electronic
ISBN : 1789858712

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Innovations In Assisted Reproduction Technology by Nidhi Sharma,Sudakshina Chakrabarti,Yona Barak,Adrian Ellenbogen Pdf

Author : Karin B. Michels
Publisher : Springer Science & Business Media
Page : 450 pages
File Size : 44,5 Mb
Release : 2012-01-02
Category : Medical
ISBN : 9789400724952

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Epigenetic Epidemiology by Karin B. Michels Pdf

The exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly incorporate epigenetic components. The relevance of epigenetic marks, such as DNA methylation, genomic imprinting, and histone modification for disease causation has yet to be fully explored.This book covers the basic concepts of epigenetic epidemiology, discusses challenges in study design, analysis, and interpretation, epigenetic laboratory techniques, the influence of age and environmental factors on shaping the epigenome, the role of epigenetics in the developmental origins hypothesis, and provides the state of the art on the epigenetic epidemiology of various health conditions including childhood syndromes, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, autism and other neurodevelopmental disorders, psychiatric disorders, diabetes, obesity and metabolic disorders, and atherosclerosis. With contributions from: Peter Jones, Jean-Pierre Issa, Gavin Kelsey, Robert Waterland, and many other experts in epigenetics!