Highly Selective Neurotoxins

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Highly Selective Neurotoxins

Richard Kostrzewa
Highly Selective Neurotoxins Book PDF

Author : Richard Kostrzewa
Publisher : Springer Science & Business Media
Page : 410 pages
File Size : 44,5 Mb
Release : 1997-10-30
Category : Medical
ISBN : 9781592594771

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Highly Selective Neurotoxins by Richard Kostrzewa Pdf

Expert researchers critically review and evaluate the most common and important neurotoxins used today in neuroscience research. Each informative chapter thoroughly describes the significant mechanisms of action of a neurotoxin, as well as fully discussing the limits on their use and their clinical applicability. Several clinically oriented chapters are significant for neurologists treating Parkinsonism, for psychiatrists treating drug abuse and neurodegenerative disorders, and for primary care physicians treating patients with appetite suppressants. Highly Selective Neurotoxins provides all the basic knowledge needed to obtain a predictable experimental outcome with these neurotoxins.

Site-Selective Neurotoxicity

David S Lester,William Slikker Jr,Philip Lazarovici
Site Selective Neurotoxicity Book PDF

Author : David S Lester,William Slikker Jr,Philip Lazarovici
Publisher : CRC Press
Page : 327 pages
File Size : 45,7 Mb
Release : 2002-02-07
Category : Medical
ISBN : 9780203219096

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Site-Selective Neurotoxicity by David S Lester,William Slikker Jr,Philip Lazarovici Pdf

This unique volume provides interdisciplinary coverage of the mechanistic perspective of neurotoxicity that focuses on the site of action of known neurotoxins. It provides the reader with an insight into the common characteristics of neurotoxin action on the nervous system and examines sites of action at three levels of complexity: molecular, cellu

Selective Neurotoxicity

Hans Herken,Ferdinand Hucho
Selective Neurotoxicity Book PDF

Author : Hans Herken,Ferdinand Hucho
Publisher : Springer Science & Business Media
Page : 891 pages
File Size : 51,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642851179

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Selective Neurotoxicity by Hans Herken,Ferdinand Hucho Pdf

Following the overwhelmingly successful response to the first printing in hardcover, the hottest topics in Selective Neurotoxicity are now available in this special softcover edition". Researchers are provided with well-grounded information on the cellular and subcellular targets of neurotoxins and their mode of action at the level of ion-channels, receptors and neurotransmitters. The use of bacterial toxins as a tool in neuroscientific research is an important aspect in this context. The chapters that interest clinicians as well deal with protective barriers in the peripheral and central nervous system and metabolic disorders that cause neurotoxins to be built up in the human body. The induction of tumors by neuroptropic carcinogens is included.

Environmental Neurotoxicology

National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Neurotoxicology and Models for Assessing Risk
Environmental Neurotoxicology Book PDF

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Neurotoxicology and Models for Assessing Risk
Publisher : National Academies Press
Page : 167 pages
File Size : 50,6 Mb
Release : 1992-02-01
Category : Science
ISBN : 9780309045315

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Environmental Neurotoxicology by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Neurotoxicology and Models for Assessing Risk Pdf

Scientists agree that exposure to toxic agents in the environment can cause neurological and psychiatric illnesses ranging from headaches and depression to syndromes resembling parkinsonism. It can even result in death at high exposure levels. The emergence of subclinical neurotoxicity-the concept that long-term impairments can escape clinical detection-makes the need for risk assessment even more critical. This volume paves the way toward definitive solutions, presenting the current consensus on risk assessment and environmental toxicants and offering specific recommendations. The book covers: The biologic basis of neurotoxicity. Progress in the application of biologic markers. Reviews of a wide range of in vitro and in vivo testing techniques. The use of surveillance and epidemiology to identify neurotoxic hazards that escape premarket screening. Research needs. This volume will be an important resource for policymakers, health specialists, researchers, and students.

Protein Engineering and Design

Paul R. Carey
Protein Engineering and Design Book PDF

Author : Paul R. Carey
Publisher : Elsevier
Page : 361 pages
File Size : 44,8 Mb
Release : 1996-06-21
Category : Science
ISBN : 0080539971

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Protein Engineering and Design by Paul R. Carey Pdf

The design and production of novel peptides and proteins occupy pivotal positions in science and technology and will continue to do so in the 21st century. Protein Engineering and Design outlines the rapid advances in computer-based modeling, protein engineering, and methods needed for protein and peptide preparation and characterization. This indispensable reference lays the groundwork for understanding this multidisciplinary activity while providing an introduction for researchers and students to the field of protein design. Introduces and defines the techniques involved in protein engineering and design Provides a concise overview of key technologies involved and demonstrates their contributions to the specialized design and production of novel proteins and peptides

Botulinum Neurotoxins

Andreas Rummel,Thomas Binz
Botulinum Neurotoxins Book PDF

Author : Andreas Rummel,Thomas Binz
Publisher : Springer Science & Business Media
Page : 322 pages
File Size : 46,7 Mb
Release : 2012-12-14
Category : Medical
ISBN : 9783642335709

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Botulinum Neurotoxins by Andreas Rummel,Thomas Binz Pdf

The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion. Also basic scientists value the botulinum neurotoxin as molecular tool for dissecting mechanisms of exocytosis. This book will cover the most recent molecular details of botulinum neurotoxin, its mechanism of action as well as its detection and application.

War Neurology

L. Tatu,J. Bogousslavsky
War Neurology Book PDF

Author : L. Tatu,J. Bogousslavsky
Publisher : Karger Medical and Scientific Publishers
Page : 244 pages
File Size : 41,6 Mb
Release : 2016-04-04
Category : Medical
ISBN : 9783318056068

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War Neurology by L. Tatu,J. Bogousslavsky Pdf

Interest in the history of neurological science has increased significantly during the last decade, but the significance of war has been overlooked in related research. In contrast, this book highlights war as a factor of progress in neurological science. Light is shed on this little-known topic through accounts given by neurologists in war, experiences of soldiers suffering from neurological diseases, and chapters dedicated to neurology in total and contemporary war. Written by experts, the contributions in this book focus on the Napoleonic Wars, the American Civil War, the Franco-Prussian War of 1870, World Wars I and II, and recent conflicts such as Vietnam or Afghanistan. Comprehensive yet concise and accessible, this book serves as a fascinating read for neurologists, neurosurgeons, psychiatrists, historians, and anyone else interested in the history of neurology.

Handbook of Neurotoxicity

Richard M. Kostrzewa
Handbook of Neurotoxicity Book PDF

Author : Richard M. Kostrzewa
Publisher : Springer Nature
Page : 2551 pages
File Size : 45,5 Mb
Release : 2023-01-02
Category : Medical
ISBN : 9783031150807

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Handbook of Neurotoxicity by Richard M. Kostrzewa Pdf

This handbook is a reference source for identifying, characterizing, instructing on use, and describing outcomes of neurotoxin treatments – to understand mechanisms associated with toxin use; to project outcomes of neurotoxin treatments; to gauge neurotoxins as predictors of events leading to neurodegenerative disorders and as aids to rational use of neurotoxins to model disease entities. Neuroprotection is approached in different manners including those 1) afforded by therapeutic agents – clinical and preclinical; or 2) by non-drug means, such as exercise. The amorphous term ‘neurotoxin’ is discussed in terms of the possible eventuality of a neuroprotectant producing an outcome of excess neuronal survival and a behavioral spectrum that might produce a dysfunction – akin to a neurotoxin’s effect. This new edition significantly expands on the information provided in the first edition, providing the latest research in neurotoxicity and highlighting the relationship between specific neurotoxins and the neurodegenerative disorders they can cause. It also includes new sections on the neurotoxicity of heavy metals, fungi, and snake venom. The Handbook of Neurotoxicity is thus an instructive and valuable guide towards understanding the role of neurotoxins/neurotoxicity in the expansive field of Neuroscience, and is an indispensable tool for laboratory investigators, neuroscientists, and clinical researchers.

Snake Venoms

P. Gopalakrishnakone,Hidetoshi Inagaki,Ashis K. Mukherjee,Tarek R. Rahmy,Carl-Wilhelm Vogel
Snake Venoms Book PDF

Author : P. Gopalakrishnakone,Hidetoshi Inagaki,Ashis K. Mukherjee,Tarek R. Rahmy,Carl-Wilhelm Vogel
Publisher : Springer
Page : 0 pages
File Size : 43,9 Mb
Release : 2017-02-14
Category : Medical
ISBN : 940076409X

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Snake Venoms by P. Gopalakrishnakone,Hidetoshi Inagaki,Ashis K. Mukherjee,Tarek R. Rahmy,Carl-Wilhelm Vogel Pdf

In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, Toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, Diabetes, Chronic Pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to Toxinology. The Handbook of Toxinology aims to address this gap and cover the field of Toxinology comprehensively.

Botulinum and Tetanus Neurotoxins

B.R. DasGupta
Botulinum and Tetanus Neurotoxins Book PDF

Author : B.R. DasGupta
Publisher : Springer Science & Business Media
Page : 671 pages
File Size : 54,9 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781475795424

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Botulinum and Tetanus Neurotoxins by B.R. DasGupta Pdf

Three days in Madison have thoroughly modified my view on clostridial neurotoxins. While still realizing the numerous activating, modifying and protective inputs, I cannot judge the meaningfulness of the meeting impartially. Neither may the reader expect a complete summary of all presentations. Collected in this volume, they speak for themselves without requiring an arbiter. Instead I shall write down my very personal opinions as a researcher who has studied clostridial neurotoxins for nearly 25 years. Comparable conferences have been rare during this time. A comprehensive symposium 4 on C. botulinum neurotoxins has been organized at Ft. Detrick. International conferences on tetanus have been held regularly under the auspices of the Wodd Health Organization. One or maximally two days of these meetings have been devoted to tetanus toxin and its actions whereas the sponsor and the majority of the participants have been interested mainly in epidemiology, prevention and treatment of tetanus as a disease (see refs. 5,6). Some aspects of clostridial neurotoxins have been addressed in the context of bacterial toxins, in particular in the biennial European workshops. 1-3,7,8 The Madison meeting differed from the previous ones in three aspects. First, it covered both tetanus and botulinum neurotoxins. The fusion was justified because of their huge similarities in primary structure, in their mode of action and in their cellular targets. Second, the meeting was not limited to toxins but drew some lines on which modern neurobiology might proceed.

The Comprehensive Sourcebook of Bacterial Protein Toxins

Joseph E. Alouf,Daniel Ladant,Michel R. Popoff
The Comprehensive Sourcebook of Bacterial Protein Toxins Book PDF

Author : Joseph E. Alouf,Daniel Ladant,Michel R. Popoff
Publisher : Elsevier
Page : 1072 pages
File Size : 53,6 Mb
Release : 2005-12-20
Category : Science
ISBN : 9780080456980

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The Comprehensive Sourcebook of Bacterial Protein Toxins by Joseph E. Alouf,Daniel Ladant,Michel R. Popoff Pdf

This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates. Edited by two of the most highly regarded experts in the field from the Institut Pasteur, France 14 brand new chapters dedicated to coverage of historical and general aspects of toxinology Includes the major toxins of both basic and clinical interest are described in depth Details applied aspects of toxins such as therapy, vaccinology, and toolkits in cell biology Evolutionary and functional aspects of bacterial toxins evaluated and summarized Toxin applications in cell biology presented Therapy (cancer therapy, dystonias) discussed Vaccines (native and genetically engineered vaccines) featured Toxins discussed as biological weapons, comprising chapters on anthrax, diphtheria, ricin etc.

Diagnosis and Management in Parkinson's Disease

Colin R Martin,Victor R Preedy
Diagnosis and Management in Parkinson s Disease Book PDF

Author : Colin R Martin,Victor R Preedy
Publisher : Academic Press
Page : 784 pages
File Size : 47,7 Mb
Release : 2020-08-13
Category : Medical
ISBN : 9780128159477

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Diagnosis and Management in Parkinson's Disease by Colin R Martin,Victor R Preedy Pdf

Diagnosis and Management in Parkinson's Disease: The Neuroscience of Parkinson’s, Volume 1 provides a single source of material covering different scientific domains of neuropathology underlying this condition. The book covers a wide range of subjects and unravels the complex relationships between genetics, molecular biology, pharmaceutical chemistry, neurobiology, imaging, assessments, and treatment regimens. It fills a much-needed gap as a "one-stop" synopsis of everything concerning the neurology and neuroscience related to Parkinson’s disease, from chemicals and cells to individuals. The book is an invaluable resource for neuroscientists, neurologists, and anyone in the field. Offers the most comprehensive coverage of a broad range of topics related to Parkinson's disease Serves as a foundational collection for neuroscientists and neurologists on the biology of disease and brain dysfunction Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations Serves as a "one-stop" source for everything you need to know about Parkinson’s disease

Biological Toxins and Bioterrorism

P. Gopalakrishnakone,Mahdi Balali-Mood,Lyndon Llewellyn,Bal Ram Singh
Biological Toxins and Bioterrorism Book PDF

Author : P. Gopalakrishnakone,Mahdi Balali-Mood,Lyndon Llewellyn,Bal Ram Singh
Publisher : Springer
Page : 0 pages
File Size : 48,8 Mb
Release : 2015-01-22
Category : Medical
ISBN : 9400758685

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Biological Toxins and Bioterrorism by P. Gopalakrishnakone,Mahdi Balali-Mood,Lyndon Llewellyn,Bal Ram Singh Pdf

Biological toxins are an important part of our world, a reality with which we need to cope, so in parallel with understanding their mechanisms of action and thereby improving our fundamental knowledge, there are successful efforts to utilize them as therapeutics against some debilitating human and animal diseases. In view of the complexity of different types of biotoxins and the broad range of toxin structure, physiology, utility, and countermeasures including regulatory issues, it was thus aimed to compile a book on biotoxins and bioweapons. This reference work in the Toxinology handbook series gathers together knowledge from around the globe about naturally inspired and manufactured biological weapons. The authors describe how they work; how authorities may detect their presence, prevent their use, and diagnose their impacts; and the means by which medical and paramedical professionals may treat victims. Also described are how they have been used to further our knowledge and what insights they have given us into evolutionary and physiological processes. Finally, it is also discussed how these toxins can be used as therapeutics and what the implications of such therapeutics are to their use as biothreat agents. This volume provides a reference accessible to scientists, educators, and medical experts alike with an interest in biotoxins, focusing on the major toxins used as bioweapons. Regulatory agencies will also benefit from the information provided in this book. Some in the intended audience may need to understand how they elicit their effects and how we can defend ourselves against them. Others may be interested in the sometimes colorful histories that surround this subset of biotoxins that can be and, in some cases, have been used as weapons.

Neurotoxicology

G. Jean Harry,Hugh A. Tilson
Neurotoxicology Book PDF

Author : G. Jean Harry,Hugh A. Tilson
Publisher : CRC Press
Page : 334 pages
File Size : 44,7 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781420054880

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Neurotoxicology by G. Jean Harry,Hugh A. Tilson Pdf

This new edition presents an integrated approach to neurotoxicology, the study of organisms' responses to changes in their environment and how interruption of the flow of information by chemical exposure causes a wide range of effects - from learning deficits, sensory disturbances in the extremities, and muscle weakness to seizures and signs simila

Drinking Water and Health,

National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Toxicology and Environmental Health Hazards,Safe Drinking Water Committee
Drinking Water and Health Book PDF

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Toxicology and Environmental Health Hazards,Safe Drinking Water Committee
Publisher : National Academies Press
Page : 476 pages
File Size : 46,8 Mb
Release : 1986-02-01
Category : Nature
ISBN : 9780309036870

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Drinking Water and Health, by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Toxicology and Environmental Health Hazards,Safe Drinking Water Committee Pdf

The most recent volume in the Drinking Water and Health series contains the results of a two-part study on the toxicity of drinking water contaminants. The first part examines current practices in risk assessment, identifies new noncancerous toxic responses to chemicals found in drinking water, and discusses the use of pharmacokinetic data to estimate the delivered dose and response. The second part of the book provides risk assessments for 14 specific compounds, 9 presented here for the first time.