Microdrops And Digital Microfluidics

Author : Jean Berthier
Publisher : William Andrew
Page : 560 pages
File Size : 44,7 Mb
Release : 2012-12-31
Category : Science
ISBN : 9781455728008

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Micro-Drops and Digital Microfluidics by Jean Berthier Pdf

In this 2nd edition of Micro-Drops and Digital Microfluidics, Jean Berthier explores the fundamentals and applications of digital microfluidics, enabling engineers and scientists to design this important enabling technology into devices and harness the considerable potential of digital microfluidics in testing and data collection. This book describes the most recent developments in digital microfluidics, with a specific focus on the computational, theoretical and experimental study of microdrops. Unique in its emphasis on digital microfluidics and with diverse applications ranging from drug delivery to point-of-care diagnostic chips, organic synthesis to microreactors, Micro-Drops and Digital Microfluidics meets the needs of audiences across the fields of bioengineering and biotechnology, and electrical and chemical engineering. Authoritative reporting on the latest changes in microfluidic science, where microscopic liquid volumes are handled as ""microdrops"" and separately from ""nanodrops." A methodical examination of how liquid microdrops behave in the complex geometries of modern miniaturized systems and interact with different morphological (micro-fabricated, textured) solid substrates A thorough explanation of how capillary forces act on liquid interfaces in contact with micro-fabricated surfaces Analysis of how droplets can be manipulated, handled, or transported using electric fields (electrowetting), acoustic actuation (surface acoustic waves), or by a carrier liquid (microflow) A fresh perspective on the future of microfluidics

Author : Jean Berthier
Publisher : William Andrew Pub
Page : 441 pages
File Size : 48,5 Mb
Release : 2008
Category : Technology & Engineering
ISBN : 0815515448

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Microdrops and Digital Microfluidics by Jean Berthier Pdf

In this 2nd edition of Micro-Drops and Digital Microfluidics, Jean Berthier explores the fundamentals and applications of digital microfluidics, enabling engineers and scientists to design this important enabling technology into devices and harness the considerable potential of digital microfluidics in testing and data collection. This book describes the most recent developments in digital microfluidics, with a specific focus on the computational, theoretical and experimental study of microdrops. Unique in its emphasis on digital microfluidics and with diverse applications ranging from drug delivery to point-of-care diagnostic chips, organic synthesis to microreactors, Micro-Drops and Digital Microfluidics meets the needs of audiences across the fields of bioengineering and biotechnology, and electrical and chemical engineering. . Authoritative reporting on the latest changes in microfluidic science, where microscopic liquid volumes are handled as ""microdrops"" and separately from ""nanodrops."" . A methodical examination of how liquid microdrops behave in the complex geometries of modern miniaturized systems and interact with different morphological (micro-fabricated, textured) solid substrates. . A thorough explanation of how capillary forces act on liquid interfaces in contact with micro-fabricated surfaces. . Analysis of how droplets can be manipulated, handled, or transported using electric fields (electrowetting), acoustic actuation (surface acoustic waves), or by a carrier liquid (microflow). . A fresh perspective on the future of microfluidics.

Author : Jean Berthier
Publisher : Elsevier
Page : 350 pages
File Size : 54,7 Mb
Release : 2008-03-20
Category : Technology & Engineering
ISBN : 9780815518358

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Micro-Drops and Digital Microfluidics by Jean Berthier Pdf

After spending over 12 years developing new microsystems for biotechnology – especially concerned with the microfluidic aspects of these devices – Jean Berthier is considered a leading authority in the field. Now, following the success of his book, Microfluidics for Biotechnology, Dr. Berthier returns to explain how new miniaturization techniques have dramatically expanded the area of microfluidic applications and microsystems into microdrops and digital microfluidics. Engineers interested in designing more versatile microsystems and students who seek to learn the fundamentals of microfluidics will all appreciate the wide-range of information found within Microdrops and Digital Microfluidics. The most recent developments in digital microfluidics are described in clear detail, with a specific focus on the computational, theoretical and experimental study of microdrops. • Over 500 equations and more than 400 illustrations. • Authoritative reporting on the latest changes in microfluidic science, where microscopic liquid volumes are handled as ""microdrops"" and separately from ""nanodrops."" • A methodical examination of how liquid microdrops behave in the complex geometries of modern miniaturized systems and interact with different morphological (micro-fabricated, textured) solid substrates. • A thorough explanation of how capillary forces act on liquid interfaces in contact with micro-fabricated surfaces. • Analysis of how droplets can be manipulated, handled, or transported using electric fields (electrowetting), acoustic actuation (surface acoustic waves), or by a carrier liquid (microflow). • A fresh perspective on the future of microfluidics.

Author : Jean Berthier,Pascal Silberzan
Publisher : Artech House
Page : 503 pages
File Size : 47,7 Mb
Release : 2010
Category : Science
ISBN : 9781596934443

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Microfluidics for Biotechnology by Jean Berthier,Pascal Silberzan Pdf

The application of microfluidics to biotechnology is an exciting new area that has already begun to revolutionize how researchers study and manipulate macromolecules like DNA, proteins and cells in vitro and within living organisms. Now in a newly revised and expanded second edition, the Artech House bestseller, Microfluidics for Biotechnology brings you to the cutting edge of this burgeoning field. Among the numerous updates, the second edition features three entirely new chapters on: non-dimensional numbers in microfluidics; interface, capillarity and microdrops; and digital, two-phase and droplet microfluidics.Presenting an enlightening balance of numerical approaches, theory, and experimental examples, this book provides a detailed look at the mechanical behavior of the different types of micro/nano particles and macromolecules that are used in biotechnology. You gain a solid understanding of microfluidics theory and the mechanics of microflows and microdrops. The book examines the diffusion of species and nanoparticles, including continuous flow and discrete Monte-Carlo methods.This unique volume describes the transport and dispersion of biochemical species and particles. You learn how to model biochemical reactions, including DNA hybridization and enzymatic reactions. Moreover, the book helps you master the theory, applications, and modeling of magnetic beads behavior and provides an overview of self-assembly and magnetic composite. Other key topics include the electric manipulation of micro/nanoparticles and macromolecules and the experimental aspects of biological macromolecule manipulation.

Author : Sanket Goel,Sohan Dudala
Publisher : Elsevier
Page : 276 pages
File Size : 52,8 Mb
Release : 2024-03-11
Category : Technology & Engineering
ISBN : 9780443154171

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Droplet and Digital Microfluidics by Sanket Goel,Sohan Dudala Pdf

Droplet and Digital Microfluidics: Ideation to Implementation is a detailed introduction to the dynamics of droplet and digital microfluidics, also featuring coverage of new methods and applications. The explosion of applications of microelectromechanical systems (MEMS) in recent years has driven demand for expertise and innovation in fluid flow in the microchannels they contain. In this book, detailed descriptions of methods for biological and chemical applications of microfluidics are provided, along with supporting foundational knowledge. In addition, the principles of droplet and digital microfluidics are explained, along with their different applications and governing physics. New additions to the technological knowledgebase that enable advances in droplet and digital microfluidics include machine learning and exciting future avenues for research. Provides step-by-step fabrication, testing, and characterization instructions in each chapter to support implementation Includes explanations of applications and methods in biological and chemical settings Describes the path to automation of digital and droplet microfluidic platforms

Author : Jean Berthier,Kenneth A. Brakke
Publisher : John Wiley & Sons
Page : 395 pages
File Size : 48,9 Mb
Release : 2012-04-30
Category : Technology & Engineering
ISBN : 9781118401330

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The Physics of Microdroplets by Jean Berthier,Kenneth A. Brakke Pdf

The Physics of Microdroplets gives the reader the theoretical and numerical tools to understand, explain, calculate, and predict the often nonintuitive observed behavior of droplets in microsystems. Microdrops and interfaces are now a common feature in most fluidic microsystems, from biology, to biotechnology, materials science, 3D-microelectronics, optofluidics, and mechatronics. On the other hand, the behavior of droplets and interfaces in today's microsystems is complicated and involves complex 3D geometrical considerations. From a numerical standpoint, the treatment of interfaces separating different immiscible phases is difficult. After a chapter dedicated to the general theory of wetting, this practical book successively details: The theory of 3D liquid interfaces The formulas for volume and surface of sessile and pancake droplets The behavior of sessile droplets The behavior of droplets between tapered plates and in wedges The behavior of droplets in microchannels The effect of capillarity with the analysis of capillary rise The onset of spontaneous capillary flow in open microfluidic systems The interaction between droplets, like engulfment The theory and application of electrowetting The state of the art for the approach of 3D-microelectronics using capillary alignment

Author : Xiujun James Li,Yu Zhou
Publisher : Elsevier
Page : 676 pages
File Size : 43,7 Mb
Release : 2013-10-31
Category : Technology & Engineering
ISBN : 9780857097040

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Microfluidic Devices for Biomedical Applications by Xiujun James Li,Yu Zhou Pdf

Microfluidics or lab-on-a-chip (LOC) is an important technology suitable for numerous applications from drug delivery to tissue engineering. Microfluidic devices for biomedical applications discusses the fundamentals of microfluidics and explores in detail a wide range of medical applications. The first part of the book reviews the fundamentals of microfluidic technologies for biomedical applications with chapters focussing on the materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies. Chapters in part two examine applications in drug discovery and controlled-delivery including micro needles. Part three considers applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds and stem cell engineering. The final part of the book covers the applications of microfluidic devices in diagnostic sensing, including genetic analysis, low-cost bioassays, viral detection, and radio chemical synthesis. Microfluidic devices for biomedical applications is an essential reference for medical device manufacturers, scientists and researchers concerned with microfluidics in the field of biomedical applications and life-science industries. Discusses the fundamentals of microfluidics or lab-on-a-chip (LOC) and explores in detail a wide range of medical applications Considers materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies Considers applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds and stem cell engineering

Author : Jean Berthier,Ashleigh B Theberge,Erwin Berthier
Publisher : Morgan & Claypool Publishers
Page : 171 pages
File Size : 54,6 Mb
Release : 2019-09-04
Category : Technology & Engineering
ISBN : 9781643276649

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Open-Channel Microfluidics by Jean Berthier,Ashleigh B Theberge,Erwin Berthier Pdf

Open microfluidics, the study of microflows having a boundary with surrounding air, encompasses different aspects such as paper or thread-based microfluidics, droplet microfluidics and open-channel microfluidics. Open-channel microflow is a flow at the micro-scale, guided by solid structures, and having at least a free boundary (with air or vapor) other than the advancing meniscus. This book is devoted to the study of open-channel microfluidics which (contrary to paper or thread or droplet microfluidics) is still very sparsely documented, but bears many new applications in biology, biotechnology, medicine, material and space sciences. Capillarity being the principal force triggering an open microflow, the principles of capillarity are first recalled. The onset of open-channel microflow is next analyzed and the fundamental notion of generalized Cassie angle (the apparent contact angle which accounts for the presence of air) is presented. The theory of the dynamics of open-channel microflows is then developed, using the notion of averaged friction length which accounts for the presence of air along the boundaries of the flow domain. Different channel morphologies are studied and geometrical features such as valves and capillary pumps are examined. An introduction to two-phase open-channel microflows is also presented showing that immiscible plugs can be transported by an open-channel flow. Finally, a selection of interesting applications in the domains of space, materials, medicine and biology is presented, showing the potentialities of open-channel microfluidics.

Author : Philip Day,Andreas Manz,Yonghao Zhang
Publisher : Springer Science & Business Media
Page : 249 pages
File Size : 45,8 Mb
Release : 2012-07-28
Category : Science
ISBN : 9781461432654

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Microdroplet Technology by Philip Day,Andreas Manz,Yonghao Zhang Pdf

Microdroplet technology has recently emerged to provide new and diverse applications via microfluidic functionality, especially in various areas of biology and chemistry. This book, then, gives an overview of the principle components and wide-ranging applications for state-of-the-art of droplet-based microfluidics. Chapter authors are internationally-leading researchers from chemistry, biology, physics and engineering that present various key aspects of micrdroplet technology -- fundamental flow physics, methodology and components for flow control, applications in biology and chemistry, and a discussion of future perspectives. This book acts as a reference for academics, post-graduate students, and researcher wishing to deepen their understand of microfluidics and introduce optimal design and operation of new droplet-based microfluidic devices for more comprehensive analyte assessments.

Author : Pradipta Kumar Panigrahi
Publisher : John Wiley & Sons
Page : 554 pages
File Size : 52,5 Mb
Release : 2016-02-15
Category : Science
ISBN : 9781118298411

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Transport Phenomena in Microfluidic Systems by Pradipta Kumar Panigrahi Pdf

Fully comprehensive introduction to the rapidly emerging area of micro systems technology Transport Phenomena in Micro Systems explores the fundamentals of the new technologies related to Micro-Electro-Mechanical Systems (MEMS). It deals with the behavior, precise control and manipulation of fluids that are geometrically constrained to a small, typically sub-millimeter, scale, such as nl, pl, fl, small size, low energy consumption, effects of the micro domain and heat transfer in the related devices. The author describes in detail and with extensive illustration micro fabrication, channel flow, transport laws, magnetophoresis, micro scale convection and micro sensors and activators, among others. This book spans multidisciplinary fields such as material science and mechanical engineering, engineering, physics, chemistry, microtechnology and biotechnology. Brings together in one collection recent and emerging developments in this fast-growing area of micro systems Covers multidisciplinary fields such as materials science, mechanical engineering, microtechnology and biotechnology, et al Comprehensive coverage of analytical models in microfluidics and MEMS technology Introduces micro fluidics applications include the development of inkjet printheads, micro-propulsion, and micro thermal technologies Presented in a very logical format Supplies readers with problems and solutions

Author : 鄭宇翔
Publisher : Unknown
Page : 0 pages
File Size : 46,7 Mb
Release : 2022
Category : Electronic
ISBN : OCLC:1432060614

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Simultaneous Multiple-droplet Generation on Digital Microfluidics Chip by 鄭宇翔 Pdf

Author : Philip Y. Paik,Krishnendu Chakrabarty,Vamsee Krishna Pamula
Publisher : Artech House Publishers
Page : 216 pages
File Size : 55,5 Mb
Release : 2007
Category : Science
ISBN : UOM:39015069317678

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Adaptive Cooling of Integrated Circuits Using Digital Microfluidics by Philip Y. Paik,Krishnendu Chakrabarty,Vamsee Krishna Pamula Pdf

Thanks to increasing power consumption and component density, localized hot spots are becoming a serious challenge in IC (integrated circuit) chip design - so serious, in fact, that Intel recently had to yank a circuit because it was literally burning. For IC engineers grappling with high power dissipation and thermal issues, new droplet-based cooling techniques using digital microfluidics technology could provide the solution. This definitive guide paves the way, with design and implementation methodologies and prototypes for utilizing this groundbreaking technology. After reviewing cooling principles and current bulk cooling methods, the book brings engineers up to speed on emerging droplet-based architectures. Amply illustrated, this milestone work will prove invaluable in tackling IC heat issues that existing methods can no longer address.

Author : Ka-Meng Lei,Pui-In Mak,Man-Kay Law,Rui Paulo Martins
Publisher : Springer
Page : 102 pages
File Size : 55,7 Mb
Release : 2017-10-12
Category : Technology & Engineering
ISBN : 9783319678252

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Handheld Total Chemical and Biological Analysis Systems by Ka-Meng Lei,Pui-In Mak,Man-Kay Law,Rui Paulo Martins Pdf

The book Handheld Total Chemical and Biological Analysis Systems: Bridging NMR, Digital Microfluidics, and Semiconductors centers on the complete design of Nuclear Magnetic Resonance (NMR) microsystems for in vitro chemical and biological assays based on semiconductor chips and portable magnet. Different sensing mechanisms for CMOS in vitro assay are compared, key design criteria of the CMOS transceiver for NMR measurement are revealed, and system-level optimizations of the CMOS NMR platform utilizing digital microfluidic and diverse functions of the CMOS technology are discussed. Two CMOS NMR platforms are implemented, each of these focuses on different aspect of optimization.

Author : Eric R. Lee
Publisher : CRC Press
Page : 272 pages
File Size : 44,5 Mb
Release : 2018-10-03
Category : Technology & Engineering
ISBN : 9781420039986

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Microdrop Generation by Eric R. Lee Pdf

The applications and use of inkjet-like microfluidic drop ejectors have grown rapidly in many fields, including biotechnology, drug discovery, combinatorial chemistry, and microfabrication. Yet to date, end users and even designers of microdrop systems for scientific applications have had no books to reference on the subject. Microdrop Generation meets the needs of all those who need to understand the physics and engineering behind microdrop technology. It also contains detailed, how-to information on the practical construction, operation, troubleshooting, and fluid formulation for microdrop ejection systems. Written by a highly experienced practitioner of the art, the book is organized as a self-contained tutorial of microdrop technology ideal for those new to the field.

Author : Yang Zhao,Krishnendu Chakrabarty
Publisher : Springer
Page : 204 pages
File Size : 41,8 Mb
Release : 2012-07-24
Category : Technology & Engineering
ISBN : 1461403693

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Design and Testing of Digital Microfluidic Biochips by Yang Zhao,Krishnendu Chakrabarty Pdf

This book provides a comprehensive methodology for automated design, test and diagnosis, and use of robust, low-cost, and manufacturable digital microfluidic systems. It focuses on the development of a comprehensive CAD optimization framework for digital microfluidic biochips that unifies different design problems. With the increase in system complexity and integration levels, biochip designers can utilize the design methods described in this book to evaluate different design alternatives, and carry out design-space exploration to obtain the best design point.