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Modeling Excitable Tissue by Aslak Tveito,Kent-Andre Mardal,Marie E. Rognes Pdf
This open access volume presents a novel computational framework for understanding how collections of excitable cells work. The key approach in the text is to model excitable tissue by representing the individual cells constituting the tissue. This is in stark contrast to the common approach where homogenization is used to develop models where the cells are not explicitly present. The approach allows for very detailed analysis of small collections of excitable cells, but computational challenges limit the applicability in the presence of large collections of cells.
Modeling Excitable Tissue by Aslak Tveito,Kent-Andre Mardal,Marie E. Rognes Pdf
This open access volume presents a novel computational framework for understanding how collections of excitable cells work. The key approach in the text is to model excitable tissue by representing the individual cells constituting the tissue. This is in stark contrast to the common approach where homogenization is used to develop models where the cells are not explicitly present. The approach allows for very detailed analysis of small collections of excitable cells, but computational challenges limit the applicability in the presence of large collections of cells.
Neuroprosthetics by Kenneth W. Horch,Gurpreet S. Dhillon Pdf
A study of neuroprosthetics. It is broadly divided into three sections which address: neuroanatomy and neurophysiology, biomaterials and biocompatibility, stimulation and recording techniques; clinical applications of neuroprosthetics; and future developments.
Modelling Organs, Tissues, Cells and Devices by Socrates Dokos Pdf
This book presents a theoretical and practical overview of computational modeling in bioengineering, focusing on a range of applications including electrical stimulation of neural and cardiac tissue, implantable drug delivery, cancer therapy, biomechanics, cardiovascular dynamics, as well as fluid-structure interaction for modelling of organs, tissues, cells and devices. It covers the basic principles of modeling and simulation with ordinary and partial differential equations using MATLAB and COMSOL Multiphysics numerical software. The target audience primarily comprises postgraduate students and researchers, but the book may also be beneficial for practitioners in the medical device industry.
Modeling Electrochemical Dynamics and Signaling Mechanisms in Excitable Cells with Pathological Case Studies by Tetsuya Watanabe Pdf
Modeling Electrochemical Dynamics and Signaling Mechanisms in Excitable Cells with Pathological Case Studies covers the neuronal cell communication system in excitable cells, recognizing the most relevant mechanisms of cell communication. Along with new findings in biotechnology, medicine and pathological cases for clinicians, the book highlights electrochemical potential in living nerve and muscle cells. Written for physiological scientists, pharmaceutical scientists, medical doctors, biologists and physicists, this book an essential read for a real understanding of the signals as we see them. Covers neuronal cell communication systems in excitable cells Presents new findings in biotechnology that are being applied in medicine and pathological cases Covers mathematical and physical bases for readers without background in these fields
Calcium Entry Channels in Non-Excitable Cells by Juliusz Ashot Kozak,James W. Putney, Jr. Pdf
Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.
Neuroprosthetics: Theory And Practice (Second Edition) by Horch Kenneth W,Kipke Daryl R Pdf
This is an updated and abridged edition of the original volume published in 2004. Like its predecessor it is targeted for students of bioengineering, biomedical engineering, applied physiology, biological cybernetics and related fields; for engineers and scientists who have an interest in neuroprosthetics; and for medical practitioners using products of that field. The practice of neuroprosthetics requires a fundamental understanding of the anatomy and physiology of the nervous system, mathematical neurobiology, material science, electrochemistry, and electrophysiology. The text assumes some familiarity with basic anatomy, physiology, calculus, electrophysiology and bioinstrumentation, which typically are covered in undergraduate and first year graduate bioengineering curricula. These areas are also reviewed here, with the aim of consolidating principles fundamental to understanding the field. With that as background, the book then presents an overview of the field with detailed emphasis in selected areas of neural interfaces and neuroprostheses. The covered topics provide readers with sufficient information to understand the theory, rationale, design, and functioning of neuroprosthetic devices currently in clinical use and under development. The current volume is shorter than its predecessor. This has been achieved by reducing some of the repetition present in certain chapters of the earlier edition and eliminating a few chapters whose topics are now well covered in review literature readily available on the internet and elsewhere. Two chapters have been retained in their original versions to provide important background material, but the remaining chapters have either been revised by their original authors or replaced by new versions written by different authors. In addition new topics have been added to the section on existing systems.
Concurrency, Graphs and Models by Pierpaolo Degano,Rocco de Nicola,José Meseguer Pdf
This Festschrift volume, pubished in honor of Ugo Montanari on the occasion of his 65th birthday, contains 43 papers, written by friends and colleagues, all leading scientists in their own right, who congregated at a celebratory symposium held on June 12, 2008, in Pisa. The volume consists of seven sections, six of which are dedicated to the main research areas to which Ugo Montanari has contributed: Graph Transformation; Constraint and Logic Programming; Software Engineering; Concurrency; Models of Computation; and Software Verification. Each of these six sections starts with an introductory paper giving an account of Ugo Montanari’s contribution to the area and describing the papers in the section. The final section consists of a number of papers giving a laudation of Ugo Montanari’s numerous achievements.
The Russian edition of this book appeared in 1969 and im mediately gained widespread recognition as a reference work for research workers interested in the physiology, biophysics, and pharmacology of excitable tissues. There are several reasons for the book's success. It deals with a key problem in biology which has recently been the subject of very intensive study and it is of great interest to a wide scientific audience. Not only the fundamentals of the modern membrane theory of biopotentials, but also the vast factual material collected in the last decades by the study of the biophysical and pharmacological properties of the ionic permeability pores of the cell membrane, are described in the book in an authoritative yet readable form. Special attention is paid in the book to the systematic analysis of the consequences of the Hodgkin-Huxley mathematical theory of the nervous impulse for the problem of excitability. The relationship between the various parameters of excitability (threshold potential, threshold current, useful time), accommodation, and the action potential on the one hand, and the constants of ionic permeability of the nerve fiber membrane, on the other hand, is subjected to detailed examination in this context. To do this, the author has made extensive use not only of experimental results obtained on isolated fibers (especially single nodes of Ran vier), but also the results of his own investigations on mathematical models of excitable membranes.
This book constitutes the refereed proceedings of the First International Conference on Digital Human Modeling, DHM 2007, held in Beijing, China in July 2007. The papers thoroughly cover the thematic area of digital human modeling, addressing the following major topics: shape and movement modeling and anthropometry, building and applying virtual humans, medical and rehabilitation applications, as well as industrial and ergonomic applications.
Differential Equations for Studies in Computational Electrophysiology by Karoline Horgmo Jæger,Aslak Tveito Pdf
This open access text aims at giving you the simplest possible introduction to differential equations that are used in models of electrophysiology. It covers models at several spatial and temporal scales with associated numerical methods. The text demonstrates that a very limited number of fundamental techniques can be used to define numerical methods for equations ranging from ridiculously simple to extremely complex systems of partial differential equations. Every method is implemented in Matlab and the codes are freely available online. By using these codes, the reader becomes familiar with classical models of electrophysiology, like the cable equation, the monodomain model, and the bidomain model. But modern models that have just started to gain attention in the field of computational electrophysiology are also presented. If you just want to read one book, it should probably not be this one, but if you want a simple introduction to a complex field, it is worth considering the present text.
Dynamical Systems, PDEs and Networks for Biomedical Applications: Mathematical Modeling, Analysis and Simulations by André H. Erhardt,Krasimira Tsaneva-Atanasova,Glenn Terje Lines,Erik Andreas Martens Pdf
Physiology of Non-Excitable Cells by J. Salánki Pdf
Advances in Physiological Sciences, Volume 3: Physiology of Non-Excitable Cells is a collection of papers presented at the 28th International Congress of Physiology, held in Budapest on July 13-19, 1980. This book is organized into five parts encompassing 36 chapters that cover the various physiological aspects of non-excitable cells and neuronal membranes. The first two parts describe cellular models of iso-osmotic and epithelial transport. The third part highlights the relationship between cell transport and cellular metabolism. This part also deals with the genetic and hormonal control of cellular transport, as well as the lipoprotein synthesis and secretion by hepatocyte. The fourth part explores cell-to-cell communication through junctional membrane channels and calmodulin. The fifth part examines the temporal structure of biological systems in the sub-second time domains. This book will be of value to physiologists, cell biologists, researchers, and biology students.
Functional Imaging and Modeling of the Heart by Alejandro F. Frangi Pdf
This book constitutes the refereed proceedings of the Third International Workshop on Functional Imaging and Modeling of the Heart, FIMH 2005, held in Barcelona, Spain in June 2005. The 47 revised full papers presented were carefully reviewed and selected from numerous submissions. The papers are organized in topical sections on modeling of the heart: anatomy extraction and description; electro-physiology and electro- and magnetography; modeling of the cardiac mechanisms and functions; and cardiac motion estimation.
