Molecular Radiation Biology

Author : Hermann Dertinger,Horst Jung
Publisher : Springer Science & Business Media
Page : 246 pages
File Size : 43,7 Mb
Release : 2013-11-09
Category : Science
ISBN : 9781468462470

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Molecular Radiation Biology by Hermann Dertinger,Horst Jung Pdf

There can hardly be any doubt that radiation will continue to be an im portant factor in our lives. Present and future advances in atomic tech nology urgently require further work on research and development in the field of radiation biology if the maximum benefit is to be obtained at minimal risk from the various kinds of radiation that form a major by product of nuclear processes. Consequently, it is also necessary to prepare students and younger scientists for doing such work. The present book originates from teaching experience gained in lectures, seminars, and discussion groups started by the undersigned in 1957 and more recently held together with Drs. Dertinger and Jung. The friendly comments given to the German edition made us feel that it might be worth while to put the results of our efforts at the disposal of those to whom English is more familiar. In agreement with the view, based on well-known facts, that most if not aIl of the more striking practical achievements have resulted from patient and careful investigations into some basic problem, the book aims at introducing the reader to the methods of thought and experiment used in molecular radiation biology as weIl as to the results obtained thereby.

Author : William A. Glass,Matesh N. Varma
Publisher : Springer Science & Business Media
Page : 512 pages
File Size : 47,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781468476279

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Physical and Chemical Mechanisms in Molecular Radiation Biology by William A. Glass,Matesh N. Varma Pdf

The fundamental understanding of the production of biological effects by ionizing radiation may well be one of the most important scientific objectives of mankind; such understanding could lead to the effective and safe utilization of the nuclear energy option. In addition, this knowledge will be of immense value in such diverse fields as radiation therapy and diagnosis and in the space program. To achieve the above stated objective, the U. S. Department of Energy (DOE) and its predecessors embarked upon a fundamental interdisciplinary research program some 35 years ago. A critical component of this program is the Radiological and Chemical Physics Program (RCPP). When the RCPP was established, there was very little basic knowledge in the fields of physics, chemistry, and biology that could be directly applied to understanding the effects of radiation on biological systems. Progress of the RCPP program in its first 15 years was documented in the proceedings of a conference held at Airlie, Virginia, in 1972. At this conference, it was clear that considerable progr:ess had been made in research on the physical and chemical processes in well-characterized systems that could be used to understand biological effects. During this period of time, most physical knowledge was obtained for the gas phase because the technology and instru mentation had not progressed to the point that measurements could be made in liquids more characteristic of biological materials.

Author : Hermann Dertinger,Horst Jung
Publisher : Unknown
Page : 236 pages
File Size : 42,9 Mb
Release : 1970
Category : Electronic
ISBN : OCLC:1162619361

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Molecular Radiation Biology by Hermann Dertinger,Horst Jung Pdf

Author : K. H. Chadwick,H. P. Leenhouts
Publisher : Springer Science & Business Media
Page : 394 pages
File Size : 53,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642815195

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The Molecular Theory of Radiation Biology by K. H. Chadwick,H. P. Leenhouts Pdf

In late 1971 we were involved in a study of the interaction of radiation with matter and were trying to use measurements of radiation fluorescence in biological molecules to indicate how radiation affected living cells. It soon became apparent that we were working in the dark; the doses we used to get a significant signal were too large to be of interest for radiation biology and although the DNA molecule appeared to be the most likely target molecule we did not know which sort of events and which sort oflesions were the most important. We decided to alter our approach to see if we could find any consistent mathematical order in the radiobiological dose relationships. We found that cell survival curves could be very usefully described by a linear-quadratic dose relationship and very soon came to the somewhat premature but, as it turned out, most effective conclusion that the induction of DNA double strand breaks should be linear-quadratic. In deciding that the DNA double strand break was the crucial and all-important lesion we were able to associate the mathematical analysis with the biology of the cell and were able to relate known properties of the DNA molecule to known radiobiological effects. On the other hand, we were restricted and brought, from an abstract two-hit lesion which could have any property one wished, down to earth, to a defined moleccular structure of nanometer dimensions and well-known functions and properties.

Author : Hermann Dertinger,Horst Jung
Publisher : Unknown
Page : 236 pages
File Size : 44,6 Mb
Release : 1970
Category : Electronic
ISBN : 3540900136

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Molecular Radiation Biology by Hermann Dertinger,Horst Jung Pdf

Author : Kenneth Chadwick
Publisher : CRC Press
Page : 241 pages
File Size : 44,8 Mb
Release : 2019-11-15
Category : Medical
ISBN : 9781000733884

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Understanding Radiation Biology by Kenneth Chadwick Pdf

This book provides a qualitative and quantitative exploration of the action of radiation on living matter which leads to a complete and coherent interpretation of radiation biology. It takes readers from radiation-induced molecular damage in the nucleus of the cell and links this damage to cellular effects such as cell killing, chromosome aberrations and mutations before exploring organ damage, organism lethality and cancer induction. It also deals with radiological protection concepts and the difficulties of predicting the dose–effect relationship for low-dose and dose rate radiation risk. The book ends with separate chapters dealing with the effects of UV light exposure and risk classification of chemical mutagens, both of which are derived by logical extensions of the radiation model. This book will provide the basic foundations of radiation biology for undergraduate and graduate students in medical physics, biomedical engineering, radiological protection, medicine, radiology and radiography. Features Presents a comprehensive insight into radiation action on living matter Contains important implications for radiological protection and regulations Provides analytical methods for applications in radiotherapy

Author : Shirley Lehnert
Publisher : CRC Press
Page : 560 pages
File Size : 47,5 Mb
Release : 2007-10-24
Category : Science
ISBN : 9781420011920

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Biomolecular Action of Ionizing Radiation by Shirley Lehnert Pdf

Embracing the transformation of radiation sciences by the recent surge of developments in molecular biology, this progressive text offers an up-to-date analysis of in vitro and in vivo molecular responses in the body induced by ionizing radiation. With a unique emphasis on medical physics applications, Biomolecular Action of Ionizing Radiation also presents a much needed, in-depth perspective on clinical applications for the treatment of cancer and radiation injuries. Based on a popular course given by the author at McGill University,the bookplaces the traditional tenets of radiation biology in the context of contemporary cell and molecular biology. Using terms that non-experts in molecular biology can understand, it clarifies the underlying mechanisms of radiation effects on molecular interactions including signal transduction pathways, modes of cell killing, and non-targeted effects. The author subsequently associates key principles and advances with potential applications, including the use of ionizing radiation as a cytotoxic and cytostatic agent, and radiosensitization by targeting molecular intermediates or signaling molecules involved in radiation-induced processes. Raising the standard for radiation biology texts that are currently available, Biomolecular Action of Ionizing Radiation is an outstanding resource for advanced undergraduate and graduate students in medical physics, radiation oncology, radiation biology, and those who have an interest in the radiation sciences and in cancer treatment.

Author : Sarah Baatout
Publisher : Springer Nature
Page : 687 pages
File Size : 51,9 Mb
Release : 2023-09-23
Category : Science
ISBN : 9783031188107

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Radiobiology Textbook by Sarah Baatout Pdf

This open access textbook focuses on the various aspects of radiobiology. The goal of radiobiological research is to better understand the effects of radiation exposure at the cellular and molecular levels in order to determine the impact on health. This book offers a unique perspective, by covering not only radiation biology but also radiation physics, radiation oncology, radiotherapy, radiochemistry, radiopharmacy, nuclear medicine, space radiation biology & physics, environmental and human radiation protection, nuclear emergency planning, molecular biology and bioinformatics, as well as the ethical, legal and social considerations related to radiobiology. This range of disciplines contributes to making radiobiology a broad and rather complex topic. This textbook is intended to provide a solid foundation to those interested in the basics and practice of radiobiological science. It is a learning resource, meeting the needs of students, scientists and medical staff with an interest in this rapidly evolving discipline, as well as a teaching tool, with accompanying teaching material to help educators.

Author : Eric J. Hall,Amato J. Giaccia
Publisher : Lippincott Williams & Wilkins
Page : 624 pages
File Size : 43,5 Mb
Release : 2018-04-16
Category : Medical
ISBN : 9781496395139

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Radiobiology for the Radiologist by Eric J. Hall,Amato J. Giaccia Pdf

Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Considered the “gold standard” in the field for over 45 years, Radiobiology for the Radiologist combines traditional and molecular radiation biology principles and appeals to students, residents, and veteran clinical practitioners. This edition continues the two-part format of previous editions and features brand-new chapters, thoroughly updated content, and hundreds of figures that provide a visual context to the information in each chapter.

Author : Matesh N. Varma,Aloke Chatterjee
Publisher : Springer Science & Business Media
Page : 262 pages
File Size : 51,5 Mb
Release : 2013-11-11
Category : Science
ISBN : 9781475797886

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Computational Approaches in Molecular Radiation Biology by Matesh N. Varma,Aloke Chatterjee Pdf

The Office of Health and Environmental Research (OHER) has supported and continues to support development of computational approaches in biology and medicine. OHER's Radiological and Chemical Physics Program initiated development of computational approaches to determine the effects produced by radiation of different quality (such as high energy electrons, protons, helium and other heavy ions, etc. ) in a variety of materials of biological interest-such as water, polymers and DNA; these include molecular excitations and sub-excitations and the production of ionization and their spatial and temporal distribution. In the past several years, significant advances have been made in computational methods for this purpose. In particular, codes based on Monte Carlo techniques have ·been developed that provide a realistic description of track-structure produced by charged particles. In addition, the codes have become sufficiently sophisticated so that it is now possible to calculate the spatial and temporal distribution of energy deposition patterns in small volumes of subnanometer and nanometer dimensions. These dimensions or resolution levels are relevant for our understanding of mechanisms at the molecular level by which radiations affect biological systems. Since the Monte Carlo track structure codes for use in radiation chemistry and radiation biology are still in the developmental stage, a number of investigators have been exploring different strategies for improving these codes.

Author : John T. Lett,Howard Adler
Publisher : Academic Press
Page : 492 pages
File Size : 45,9 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483281896

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Advances in Radiation Biology by John T. Lett,Howard Adler Pdf

Advances in Radiation Biology, Volume 9, provides an overview of the state of knowledge in radiation biology. The book contains nine chapters and begins with a study on the ways in which physical and chemical agents might trigger "regulatory dysfunction" and how these agents might interact with each other. This is followed by separate chapters on the mechanisms underlying changes in vascular function after doses of radiation in the therapeutic range and their role in the development of late effects in normal tissues; the future of hypoxic cell sensitizers in the clinical setting; DNA strand break formation by ionizing radiation; and major pathways which result in radiation-induced loss of cellular proliferative capacity. Subsequent chapters deal with the solid-state radiation chemistry of DNA; radiosensitivity of proliferating mammalian cells; the use of microwave/radiofrequency energy cancer treatment; and the decline of basic radiobiology.

Author : Leroy G. Augenstein,Ronald Mason,Max Zelle
Publisher : Academic Press
Page : 350 pages
File Size : 42,8 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483282411

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Advances in Radiation Biology by Leroy G. Augenstein,Ronald Mason,Max Zelle Pdf

Advances in Radiation Biology, Volume 3, reflects a continuing effort to cover a wide spectrum of radiation science in this serial publication. The book contains six chapters and opens with a review of developments of physical theory in an area of interest to biophysicists. This is followed by subsequent chapters on problem of photodynamic action, which demonstrates the role of energy transfer in radiation damage development; the sensitization of biological systems by small molecules; and problems concerned with the identification and study of the biological effects of radioactive decay. Subsequent chapters deal with a survey of human radiation cytogenetics and progress in human radiobiology.

Author : I︠U︡riĭ Borisovich Kudri︠a︡shov
Publisher : Nova Publishers
Page : 372 pages
File Size : 44,5 Mb
Release : 2008
Category : Science
ISBN : 1600212808

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Radiation Biophysics (ionizing Radiations) by I︠U︡riĭ Borisovich Kudri︠a︡shov Pdf

The book is concerned with features analysis of radiation damage to living matter at different levels of its organisation, beginning from the molecular level. The general theory of the mechanisms of biological action of radiation based on four logically connected principles of radiation biology is presented for the first time. The book contains abundant material on primary and secondary processes of the response of living systems to radiation, the mechanisms of direct and indirect action of radiation through radiolysis of water and lipids; a detailed consideration of the theory of targets (DNA and biological membranes) and the problems of high- and low-dose irradiation in the context of present-day. The systemic response of the cell to irradiation (oxidative stress, endogenous background radioresistance, damage and repair of biological membranes and DNA, systemic protection against radiation) is approximated. Presentation of these important problems is preceded by an up-to-date evaluation of some aspects regarding dosimetry of ionising radiation.

Author : Leroy George Augenstein
Publisher : Unknown
Page : 404 pages
File Size : 55,9 Mb
Release : 1964
Category : International Symposium on Physical Processes in Radiation Biology
ISBN : UOM:39015004381508

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Physical Processes in Radiation Biology by Leroy George Augenstein Pdf

Author : Alison P. Casarett
Publisher : Unknown
Page : 386 pages
File Size : 52,5 Mb
Release : 1968
Category : Electronic
ISBN : YONSEI:10428887

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Radiation Biology by Alison P. Casarett Pdf