Molecular Toxicology In Caenorhabditis Elegans

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Molecular Toxicology in Caenorhabditis elegans

Dayong Wang
Molecular Toxicology in Caenorhabditis elegans Book PDF

Author : Dayong Wang
Publisher : Springer
Page : 447 pages
File Size : 46,6 Mb
Release : 2019-01-24
Category : Medical
ISBN : 9789811336331

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Molecular Toxicology in Caenorhabditis elegans by Dayong Wang Pdf

This book will focus on the molecular basis of oxidative stress induced by toxicants or stresses and various molecular signalling pathways in regulating the toxicity of toxicants or stresses in Caenorhabditis elegans. It will also cover the discussion on the aspects of response signals, G-protein coupled receptors and ion channels, specific molecular signals, and epigenetic signals involved in the regulation of toxicity from toxicants or stresses. The molecular basis for adaptive response for transgenerational toxicity of environmental toxicants or stresses will be further discussed. Nematode Caenorhabditis elegans is a classic model animal with well-described genetic and developmental backgrounds based on the study of life science, and has been further successfully and widely used in both toxicity assessment and toxicological study of various environmental toxicants or stresses. Based on related available data, this book aims at providing a systematic understanding of the knowledge system of molecular toxicology in C. elegans.

Molecular Toxicology

P. David Josephy,Bengt Mannervik
Molecular Toxicology Book PDF

Author : P. David Josephy,Bengt Mannervik
Publisher : Unknown
Page : 620 pages
File Size : 46,6 Mb
Release : 2006
Category : Molecular toxicology
ISBN : 0195176200

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Molecular Toxicology by P. David Josephy,Bengt Mannervik Pdf

The science of toxicology has progressed considerably since Molecular Toxicology was first published in 1997. New advances in biochemical and molecular biological experimental techniques have helped researchers understand the precise effects of toxins and foreign compounds on living things atthe molecular, cellular, and organismal levels. Breakthrough research has recently been completed illuminating the human genome and the role of enzymes in toxic biochemical reaction mechanisms. Toxicology now covers drug metabolism and design, carcinogenesis, programmed cell death, and DNA repair,among other subjects. The second edition captures these and other advances, and broadens its scope to address the experimental science of toxicology. The first edition of Molecular Toxicology has become an indispensable resource for graduate students in molecular and biochemical toxicology courses,as well as academic researchers and industrial researchers in toxicology. Rigorously updated and revised, the new edition commands an unrivaled authority in the field of molecular toxicology.

Exposure Toxicology in Caenorhabditis elegans

Dayong Wang
Exposure Toxicology in Caenorhabditis elegans Book PDF

Author : Dayong Wang
Publisher : Springer Nature
Page : 682 pages
File Size : 42,5 Mb
Release : 2020-08-27
Category : Medical
ISBN : 9789811561290

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Exposure Toxicology in Caenorhabditis elegans by Dayong Wang Pdf

This book focuses on exposure toxicology in C. elegans. The nematode Caenorhabditis elegans is sensitive to various environmental toxicants and stresses, and has proven to be an important animal model in both molecular and target-organ toxicology. As a result, over the past 30 years, there has been extensive research on the exposure to environmental toxicants or stresses in nematodes. Based on the available data, the book offers an introduction to the exposure system established in nematodes, discussing various aspects of endpoints that can potentially be used to assess the toxicity of environmental toxicants or stresses. Also exploring various factors affecting toxicity induction, and exposure to environmental toxicants and stresses, it allows readers to gain a systematic understanding of exposure toxicology in C. elegans.

Molecular and Biochemical Toxicology

Robert C. Smart,Ernest Hodgson
Molecular and Biochemical Toxicology Book PDF

Author : Robert C. Smart,Ernest Hodgson
Publisher : John Wiley & Sons
Page : 804 pages
File Size : 46,6 Mb
Release : 2013-03-05
Category : Science
ISBN : 9781118679722

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Molecular and Biochemical Toxicology by Robert C. Smart,Ernest Hodgson Pdf

An essential resource for graduate students, academic and industrial toxicologists, and environmental health scientists and professionals Over the course of thirty years and three editions, Introduction to Biochemical Toxicology has been an important source for coverage of the ongoing quest to define the biochemical, cellular, and molecular events induced by toxicants at the cellular and organismic levels. Now, as the principles and methods of molecular and cellular biology as well as genomic sciences play an ever increasing role in mechanistic toxicology, significant changes have been made to the book, resulting in this important new edition-now titled Molecular and Biochemical Toxicology, Fourth Edition. Much more than an introductory text, this crucial new edition has been completely revised to provide timely and thorough coverage of the underlying biochemical, molecular, and cellular mechanisms through which toxicants produce their adverse effects. Toxicological issues are covered from the molecule to the cell to the organ level. Complex methods used in toxicology are also described in a straightforward, easy-to-understand style. Additional features of this new edition include: New chapters that explore the interface between toxicology and genomic sciences, including: bioinformatics, proteomics, metabolomics, and toxicogenomics Increased emphasis on structure, mechanism, and regulation of xenobiotic metabolizing enzymes, toxicogenetics, and xenobiotic transporters Additional new chapters on: molecular epidemiology and genetic susceptibility, DNA damage and mutagenesis, DNA repair, mechanisms of cell death, mitochondrial dysfunction, metals, reproductive toxicology, developmental toxicology, and reactive oxygen/metabolites and toxicity Molecular and Biochemical Toxicology, Fourth Edition guides graduate students, toxicologists, and environmental health professionals through the principles of molecular and biochemical toxicology and the complex mechanisms of toxicity. Whether it's used in the classroom or in industry, research, or academia, this book is essential for anyone interested in understanding the molecular mechanisms through which toxicants produce adverse effects.

Toxicology at Environmentally Relevant Concentrations in Caenorhabditis elegans

Dayong Wang
Toxicology at Environmentally Relevant Concentrations in Caenorhabditis elegans Book PDF

Author : Dayong Wang
Publisher : Springer Nature
Page : 371 pages
File Size : 54,5 Mb
Release : 2022-01-20
Category : Medical
ISBN : 9789811667466

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Toxicology at Environmentally Relevant Concentrations in Caenorhabditis elegans by Dayong Wang Pdf

“This book uses Caenorhabditis elegans as model animal to introduce the toxicity induction of toxicants at environmentally relevant concentrations under different conditions. It also discusses the systematic introduction of different molecular signaling pathways, as well as G protein coupled receptors and ion channels, in regulating the toxicity of toxicants at environmentally relevant concentrations. The intestinal, neuronal, and germline molecular networks required for the regulation of toxicity of toxicants at environmentally relevant concentrations is further introduced and discussed. This book aims at providing a systematic understanding of the knowledge system on toxicology at environmentally relevant concentrations in Caenorhabditis elegans. ”

Molecular, Clinical and Environmental Toxicology

Andreas Luch
Molecular Clinical and Environmental Toxicology Book PDF

Author : Andreas Luch
Publisher : Springer Science & Business Media
Page : 470 pages
File Size : 55,6 Mb
Release : 2009-04-03
Category : Medical
ISBN : 9783764383367

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Molecular, Clinical and Environmental Toxicology by Andreas Luch Pdf

Molecular Toxicology is the first volume of a three-volume set Molecular, Clinical and Environmental Toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals in daily life. By providing intriguing insights far down to the molecular level, this work covers the entire range of modern toxicology with special emphasis on recent developments and achievements. It is written for students and professionals in medicine, science, public health and engineering who are demanding reliable information on toxic or potentially harmful agents and their adverse effects on the human body.

Molecular Toxicology

Nick Plant
Molecular Toxicology Book PDF

Author : Nick Plant
Publisher : Taylor & Francis
Page : 164 pages
File Size : 46,5 Mb
Release : 2021-02-27
Category : Science
ISBN : 9781000107005

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Molecular Toxicology by Nick Plant Pdf

Molecular Toxicology is a concise introduction to the subject, taking the reader through the theoretical principles of toxicology followed by specific examples. In the first section, the concepts behind possible mechanisms of toxicity are described (e.g. the specific enzyme or receptor system) using examples where appropriate. Following this a series of examples are used to show the extension of concept into the real world, in an organ specific manner. The book concludes with a section outlining toxicity assessment methods, where the impact of molecular biology is having a considerable impact, including DNA microarrays, proteomics and bioinformatics.

Environmental Toxicology and Toxicogenomics

Xiaoping Pan,Baohong Zhang
Environmental Toxicology and Toxicogenomics Book PDF

Author : Xiaoping Pan,Baohong Zhang
Publisher : Humana
Page : 366 pages
File Size : 42,8 Mb
Release : 2021-07-09
Category : Medical
ISBN : 1071615130

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Environmental Toxicology and Toxicogenomics by Xiaoping Pan,Baohong Zhang Pdf

This detailed book provides an accessible compendium of up-to-date methods in the fields of environmental toxicology, molecular toxicology, and toxicogenomics. Organized into four major sections, the volume examines methods utilizing model animal species, such as nematode, fruit fly, mice, chicken, and amphibians, methods using plants to study chemical toxicity, applying the Ames assay to chemical mutagenicity study, as well as methods for environmental chemical analysis. Although this book is divided into these parts, the methods can be used across species. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Environmental Toxicology and Toxicogenomics: Principles, Methods, and Applications serves as a valuable resource for the scientific community, particularly for young scientists and graduate and undergraduate students, inspiring more research in the vitally important field of environmental toxicity, molecular toxicology, and toxicogenomics.

Toxicology of Nanomaterials

Yuliang Zhao,Zhiyong Zhang,Weiyue Feng
Toxicology of Nanomaterials Book PDF

Author : Yuliang Zhao,Zhiyong Zhang,Weiyue Feng
Publisher : John Wiley & Sons
Page : 432 pages
File Size : 43,8 Mb
Release : 2016-09-08
Category : Science
ISBN : 9783527689156

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Toxicology of Nanomaterials by Yuliang Zhao,Zhiyong Zhang,Weiyue Feng Pdf

This book provides the reader with a comprehensive view of analytical methods for nanotoxicology studies. After an introduction to nanomaterials and toxicological studies, the book discusses various characterization methods of nanomaterials and continues with the detection of nanoparticles in vivo as well as in vitro. A variety of techniques in molecular toxicology of nanomaterials is presented, followed by a detailed explanation of interaction between nanoparticles and biomacromolecules, including the structure-toxicity relationships of nanomaterials. Finally, the book concludes with the advantages and challenges of the analytical methods for nanotoxicology.

Nanotoxicology in Caenorhabditis Elegans

Dayong Wang
Nanotoxicology in Caenorhabditis Elegans Book PDF

Author : Dayong Wang
Publisher : Unknown
Page : 128 pages
File Size : 49,5 Mb
Release : 2018
Category : Caenorhabditis elegans
ISBN : 9811302340

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Nanotoxicology in Caenorhabditis Elegans by Dayong Wang Pdf

This book focuses on the toxicity of engineered nanomaterials (ENMs) and their underlying physicochemical, cellular, physiological, and molecular mechanisms. Further, it covers ENMs' translocation and their targeted organ toxicology, and discusses chemical and pharmacological strategies used to combat nanotoxicity. Engineered nanomaterials (ENMs) are defined as materials with one or more dimensions of less than 100 nm, and have shown considerable promise in several areas of development. At the same time, the potential toxicity of ENMs for human health and environmental organisms is increasingly attracting attention. In addition to the typical properties of model animals, Caenorhabditis elegans is extremely sensitive to environmental toxicants, which makes it the ideal in vivo assay system for toxicological studies. C. elegans has been widely used in toxicity assessment and toxicological studies of environmental toxicants and stresses. This book provides a comprehensive summary of nanotoxicology research on C. elegans.

Advances in Molecular Toxicology

James C. Fishbein
Advances in Molecular Toxicology Book PDF

Author : James C. Fishbein
Publisher : Elsevier
Page : 322 pages
File Size : 44,7 Mb
Release : 2012-08
Category : Medical
ISBN : 9780444593894

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Advances in Molecular Toxicology by James C. Fishbein Pdf

Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of both progress on the molecular level and on advances in technological approaches employed. Cutting-edge reviews by leading workers in the discipline In-depth dissection of molecular aspects of interest to a broad range of scientists, physicians and any student in the allied disciplines Leading edge applications of technological innovations in chemistry, biochemistry and molecular medicine

Advances in Molecular Toxicology

Anonim
Advances in Molecular Toxicology Book PDF

Author : Anonim
Publisher : Academic Press
Page : 414 pages
File Size : 43,8 Mb
Release : 2016-11-11
Category : Science
ISBN : 9780444637222

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Advances in Molecular Toxicology by Anonim Pdf

Advances in Molecular Toxicology features the latest advances in the subspecialties of the broad area of molecular toxicology. This series details the study of the molecular basis of toxicology by which a vast array of agents encountered in the human environment, and produced by the human body, manifest themselves as toxins. The book is not strictly limited to documenting these examples, but also covers the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events are also reviewed by leading experts in the field. Provides cutting-edge reviews by leading workers in the discipline Includes in-depth dissection of the molecular aspects that are of interest to a broad range of scientists, physicians, and any student in the allied disciplines Presents leading-edge applications of technological innovations in chemistry, biochemistry, and molecular medicine

Cellular and Molecular Toxicology and In Vitro Toxicology

Daniel Acosta
Cellular and Molecular Toxicology and In Vitro Toxicology Book PDF

Author : Daniel Acosta
Publisher : CRC Press
Page : 184 pages
File Size : 45,7 Mb
Release : 1990-08-22
Category : Medical
ISBN : 1439805318

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Cellular and Molecular Toxicology and In Vitro Toxicology by Daniel Acosta Pdf

This work concentrates on cellular and molecular toxicity of selected well-known drugs or chemicals on the cardiovascular system. The primary objective is to provide a better understanding of the mechanisms by which xenobiotics are toxic to mammalian tissues and cells. The use of in vitro cellular and tissue systems provides attractive experimental models to assess toxic manifestations of xenobiotics. This work addresses the most recent findings on the cellular and molecular mechanisms of toxicity of several important cardiotoxic agents: doxorubicin, ethanol, cocaine, and the catecholamines. It presents an overview of vascular toxins and their biochemical effects. Included is a summary of in vitro cardiovascular techniques for assessing toxicity of xenobiotics. This publication is important for those in toxicology, tissue culture, pharmacology, in vitro toxicology, developmental biology and related areas.

Molecular Toxicology Protocols

Phouthone Keohavong,Stephen G. Grant
Molecular Toxicology Protocols Book PDF

Author : Phouthone Keohavong,Stephen G. Grant
Publisher : Humana Press
Page : 490 pages
File Size : 44,8 Mb
Release : 2004-10-22
Category : Medical
ISBN : 1588290840

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Molecular Toxicology Protocols by Phouthone Keohavong,Stephen G. Grant Pdf

A collection of cutting-edge techniques for analyzing genotoxic exposure and detecting the resulting biological effects-including endogenous metabolites-up to and including the development of cancer. The authors emphasize analytical methods that can be specifically applied to human populations and patients. Among the applications detailed are the analysis of interactions between such cellular macromolecules as DNA and proteins and chemical and physical agents, the assessment of medically relevant toxicity, and the characterization of genetic alterations induced in transgenic animals by in vivo systems. There are also methods for the analysis of genotoxic exposure during gene expression, of cytotoxicity caused by the induction of apoptosis, of genetic alterations in reporter genes and oncogenes, early (premalignant) detection of altered oncogenes, and of individual variation in biotransformation and DNA repair capacity.

Molecular Toxicology Protocols

Phouthone Keohavong,Stephen G. Grant
Molecular Toxicology Protocols Book PDF

Author : Phouthone Keohavong,Stephen G. Grant
Publisher : Humana Press
Page : 0 pages
File Size : 46,7 Mb
Release : 2014-03-13
Category : Medical
ISBN : 1627037381

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Molecular Toxicology Protocols by Phouthone Keohavong,Stephen G. Grant Pdf

Molecular Toxicology Protocols, Second Edition aims to bring together a series of articles describing validated methods to elucidate specific molecular aspects of toxicology, the emphasis being on the application of molecular methods to genetic toxicology. The volume is divided into ten parts, roughly corresponding to the spectrum of biomarkers intermediate between exposure and disease outcomes as proposed in molecular epidemiology models. Subjects of these new chapters range from preparation of fluid specimens for analysis of cellular inflammatory responses to genotoxic insults to sensitive methods for proteomic analysis and aberrant DNA methylation patterns. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Molecular Toxicology Protocols, Second Edition addresses not only the needs of molecular biologists and toxicologists, but also those of individuals interested in applying molecular methods to clinical applications, such as geneticists, pathologists, biochemists, and epidemiologists.