Cellular And Molecular Toxicology And In Vitro Toxicology

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Cellular and Molecular Toxicology and In Vitro Toxicology

Daniel Acosta
Cellular and Molecular Toxicology and In Vitro Toxicology Book PDF

Author : Daniel Acosta
Publisher : CRC Press
Page : 282 pages
File Size : 54,6 Mb
Release : 2017-07-28
Category : Medical
ISBN : 9781351367752

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Cellular and Molecular Toxicology and In Vitro Toxicology by Daniel Acosta Pdf

This work concentrates on cellular and molecular toxicity of selected well-known drugs or chemicals on the cardiovascular system. The primary objective is to provide a better understanding of the mechanisms by which xenobiotics are toxic to mammalian tissues and cells. The use of in vitro cellular and tissue systems provides attractive experimental models to assess toxic manifestations of xenobiotics. This work addresses the most recent findings on the cellular and molecular mechanisms of toxicity of several important cardiotoxic agents: doxorubicin, ethanol, cocaine, and the catecholamines. It presents an overview of vascular toxins and their biochemical effects. Included is a summary of in vitro cardiovascular techniques for assessing toxicity of xenobiotics. This publication is important for those in toxicology, tissue culture, pharmacology, in vitro toxicology, developmental biology and related areas.

Cellular and Molecular Toxicology and In Vitro Toxicology

Daniel Acosta
Cellular and Molecular Toxicology and In Vitro Toxicology Book PDF

Author : Daniel Acosta
Publisher : CRC Press
Page : 176 pages
File Size : 41,6 Mb
Release : 1990-08-22
Category : Medical
ISBN : 0849344212

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Cellular and Molecular Toxicology and In Vitro Toxicology by Daniel Acosta Pdf

This work concentrates on cellular and molecular toxicity of selected well-known drugs or chemicals on the cardiovascular system. The primary objective is to provide a better understanding of the mechanisms by which xenobiotics are toxic to mammalian tissues and cells. The use of in vitro cellular and tissue systems provides attractive experimental models to assess toxic manifestations of xenobiotics. This work addresses the most recent findings on the cellular and molecular mechanisms of toxicity of several important cardiotoxic agents: doxorubicin, ethanol, cocaine, and the catecholamines. It presents an overview of vascular toxins and their biochemical effects. Included is a summary of in vitro cardiovascular techniques for assessing toxicity of xenobiotics. This publication is important for those in toxicology, tissue culture, pharmacology, in vitro toxicology, developmental biology and related areas.

Cellular and Molecular Toxicology

J.P. Vanden Heuvel,W.F. Greenlee,G.H. Perdew,William B. Mattes
Cellular and Molecular Toxicology Book PDF

Author : J.P. Vanden Heuvel,W.F. Greenlee,G.H. Perdew,William B. Mattes
Publisher : Gulf Professional Publishing
Page : 674 pages
File Size : 53,9 Mb
Release : 2002-02-14
Category : Business & Economics
ISBN : 0444508686

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Cellular and Molecular Toxicology by J.P. Vanden Heuvel,W.F. Greenlee,G.H. Perdew,William B. Mattes Pdf

Volume 14 in the series Comprehensive Toxicology extends and complements the previously published 13-volume set. This volume will be available separately. Toxicology is the study of the nature and actions of chemicals on biological systems. In more primitive times, it really was the study of poisons. However, in the early 1500s, it was apparent to Paracelsus that "the dose differentiates a poison and a remedy". Clearly, the two most important tenets of toxicology were established during that time. The level of exposure (dose) and the duration of exposure (time) will determine the degree and nature of a toxicological response. Since that time the discipline of toxicology has made major advances in identifying and characterizing toxicants. The growth of toxicology as a scientific discipline has been driven to a large extent by the use of extremely powerful molecular and cell biology techniques. The overall aim of this volume is to demonstrate how these advances are being used to elucidate causal pathways (or linkages) for potential adverse health consequences of human exposure to environmental chemicals or radiation. A unique feature of this volume is its illustration of how carefully-designed studies of the molecular mechanisms of chemical action provide not only understanding of the potential toxicity of the chemical under investigation, but also new insights into the functioning of the biological system used as an experimental model. Each chapter contains a listing of major peer-reviewed articles and reviews and useful web-sites. In addition, each chapter contains a broad introductory section that outlines the subsequent sections. These Introductory and Overview sections are designed to be stand alone chapters, and may be packaged as a textbook in graduate level courses.

Molecular Toxicology

P. David Josephy,Bengt Mannervik
Molecular Toxicology Book PDF

Author : P. David Josephy,Bengt Mannervik
Publisher : Unknown
Page : 620 pages
File Size : 40,6 Mb
Release : 2006
Category : Molecular toxicology
ISBN : 0195176200

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Molecular Toxicology by P. David Josephy,Bengt Mannervik Pdf

The science of toxicology has progressed considerably since Molecular Toxicology was first published in 1997. New advances in biochemical and molecular biological experimental techniques have helped researchers understand the precise effects of toxins and foreign compounds on living things atthe molecular, cellular, and organismal levels. Breakthrough research has recently been completed illuminating the human genome and the role of enzymes in toxic biochemical reaction mechanisms. Toxicology now covers drug metabolism and design, carcinogenesis, programmed cell death, and DNA repair,among other subjects. The second edition captures these and other advances, and broadens its scope to address the experimental science of toxicology. The first edition of Molecular Toxicology has become an indispensable resource for graduate students in molecular and biochemical toxicology courses,as well as academic researchers and industrial researchers in toxicology. Rigorously updated and revised, the new edition commands an unrivaled authority in the field of molecular toxicology.

Molecular and Biochemical Toxicology

Robert C. Smart,Ernest Hodgson
Molecular and Biochemical Toxicology Book PDF

Author : Robert C. Smart,Ernest Hodgson
Publisher : John Wiley & Sons
Page : 1060 pages
File Size : 54,7 Mb
Release : 2018-01-04
Category : Science
ISBN : 9781119042419

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Molecular and Biochemical Toxicology by Robert C. Smart,Ernest Hodgson Pdf

Written as an advanced text for toxicology students, this book is much more than an introduction and provides in-depth information describing the underlying mechanisms through which toxicants produce their adverse responses. • Links traditional toxicology to modern molecular techniques, important for teaching to graduate courses and professional studies • Uses a didactic approach with basic biological or theoretical background for the methodology presented • Brings together and comprehensively covers a range of dynamic aspects in biochemical and molecular toxicology • Guides student and professional toxicologists in comprehending a broad range of issues, compiled and authored by a diverse group of experts • “A good introductory textbook covering the biochemical toxicology of organic substances and the relevant methodology in some detail.... It offers good value for money and can be recommended as a textbook for appropriate courses” – BTS Newsletter review of the 4th edition

Cell Culture Methods for In Vitro Toxicology

G. Stacey,Alan Doyle,Margherita Ferro
Cell Culture Methods for In Vitro Toxicology Book PDF

Author : G. Stacey,Alan Doyle,Margherita Ferro
Publisher : Springer Science & Business Media
Page : 166 pages
File Size : 52,9 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9789401709965

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Cell Culture Methods for In Vitro Toxicology by G. Stacey,Alan Doyle,Margherita Ferro Pdf

Cell Culture Methods for in vitro Toxicology introduces the reader to a range of techniques involved in the use of in vitro cell culture in toxicological studies. It deals with major cell types studied in the field of toxicology and will be useful for anyone wishing to start work with animal cell cultures or to refresh their knowledge relating to in vitro cell models. Fundamental chapters deal with the general biology of cytotoxicity and cell immortalisation these are key issues for in vitro systems addressing the `3Rs' principle. Up-to-date overviews deal with the use of cells from liver, brain and intestine. In addition, biochemical analysis of cell responses, biotransformation pathways in cells and recombinant approaches to the early detection of cell stress are also covered in detail. Prominent features of in vitro technologies also include regulation, biosafety and standardisation. Dedicated chapters deal with these issues in a practical way in order to lead the reader to the right source of information. This book provides an up-to-date, informative and practical review of cell culture methods for in vitro toxicology. It will be of equal benefit to students and experienced toxicologists with little experience of in vitro cell culture.

Cellular and Molecular Toxicology of Nanoparticles

Quaiser Saquib,Mohammad Faisal,Abdulaziz A. Al-Khedhairy,Abdulrahman A. Alatar
Cellular and Molecular Toxicology of Nanoparticles Book PDF

Author : Quaiser Saquib,Mohammad Faisal,Abdulaziz A. Al-Khedhairy,Abdulrahman A. Alatar
Publisher : Springer
Page : 346 pages
File Size : 55,7 Mb
Release : 2018-02-16
Category : Science
ISBN : 9783319720418

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Cellular and Molecular Toxicology of Nanoparticles by Quaiser Saquib,Mohammad Faisal,Abdulaziz A. Al-Khedhairy,Abdulrahman A. Alatar Pdf

This edited book is a compilation of findings on the molecular and cellular toxicity of nanoparticles (NPs) in animal cell, human cells, invertebrates. The varied selection of test models will provide better understanding about the horizon of NPs toxicity. Interaction of NPs with cells and its organelles can induce toxicological consequences, including transcriptional and translational alterations, DNA damage, cytotoxicity, oxidative stress, mitochondrial dysfunction and cell death. NPs can get internalized in cells through phagocytosis, macropinocytosis, receptor-mediated endocytosis and passive penetration, which can affect varied cell types. Readers will be benefited with the compilations on basic and molecular facet of NPs toxicity. The chapters will provide a comprehensive information on the state-of-the-art methodologies. The application of toxicogenomic approaches, which is already established in nanotoxicology, has been given special consideration to unravel the toxicodynamics of nanomaterials. Among these approaches, the high-throughput RNA sequencing (RNA-Seq), which is able to build a complete map of transcriptome across different cell types and perturbations upon NPs exposure has been included. The readers are also introduced to the less studied topic on the adsorption of biomolecules (mainly proteins) on the NPs surface, constituting the so-called “biomolecular corona”. The book has been designed for scientists engaged in NPs toxicity research. Nonetheless, it should be of interest to a variety of scientific disciplines including marine biology, environmental pollution, genetics, pharmacology, medicine, drug and food material sciences, consumer products. Also, the compilations will be of interest to the environmental watchdogs, federal regulators, risk assessors and the policy makers.

Advances in Molecular Toxicology

Claude Reiss,Simone Parvez,Gilles Labbe
Advances in Molecular Toxicology Book PDF

Author : Claude Reiss,Simone Parvez,Gilles Labbe
Publisher : VSP
Page : 590 pages
File Size : 49,8 Mb
Release : 1998-02
Category : Science
ISBN : 9067642789

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Advances in Molecular Toxicology by Claude Reiss,Simone Parvez,Gilles Labbe Pdf

Molecular toxicology is on the way to setting a new standard in toxic risk assessment, with the powerful help of concepts and methods developed in the fields of molecular and cellular biology. The methods of molecular toxicology are endowed with qualities not always secured in more traditional approaches to toxicity assessment. These methods are easily standardized, reliable, reproducible and require only tiny amounts of the xenobiotic. They are much simpler, faster and less costly than current tests on animals and can be implemented with modest laboratory resources. This volume of Advances in Molecular Toxicology represents a collection of invited papers presented at the First European Workshop on Molecular Toxicology in Sophia Antipolis, France, The book covers 8 selected topics in molecular toxicology. The first two are devoted to ''physics'', dealing respectively with advanced instrumentation enabling location and quantification of xenobiotics in cells and organs with ultimate precision, and computer-assisted assessment of risk (QSAR). A comprehensive and up-to-date survey of molecular toxicology in the pharmaceutical industry is contributed by a pioneer in this field. The third section addresses the effect of xenobiotics on cell-cycle actors. Sections 4--6 deal with molecular toxicology in skin, kidney, nerve, liver and pancreatic cells. The last two sections describe methods to probe DNA damage and repair, and immunotoxicity.

Molecular Toxicology

Nick Plant
Molecular Toxicology Book PDF

Author : Nick Plant
Publisher : Taylor & Francis
Page : 164 pages
File Size : 55,5 Mb
Release : 2021-02-27
Category : Science
ISBN : 9781000107005

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Molecular Toxicology by Nick Plant Pdf

Molecular Toxicology is a concise introduction to the subject, taking the reader through the theoretical principles of toxicology followed by specific examples. In the first section, the concepts behind possible mechanisms of toxicity are described (e.g. the specific enzyme or receptor system) using examples where appropriate. Following this a series of examples are used to show the extension of concept into the real world, in an organ specific manner. The book concludes with a section outlining toxicity assessment methods, where the impact of molecular biology is having a considerable impact, including DNA microarrays, proteomics and bioinformatics.

Molecular, Clinical and Environmental Toxicology

Andreas Luch
Molecular Clinical and Environmental Toxicology Book PDF

Author : Andreas Luch
Publisher : Springer Science & Business Media
Page : 470 pages
File Size : 53,9 Mb
Release : 2009-04-03
Category : Medical
ISBN : 9783764383367

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Molecular, Clinical and Environmental Toxicology by Andreas Luch Pdf

Molecular Toxicology is the first volume of a three-volume set Molecular, Clinical and Environmental Toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals in daily life. By providing intriguing insights far down to the molecular level, this work covers the entire range of modern toxicology with special emphasis on recent developments and achievements. It is written for students and professionals in medicine, science, public health and engineering who are demanding reliable information on toxic or potentially harmful agents and their adverse effects on the human body.

Molecular and Cellular Toxicology

Lesley Stanley
Molecular and Cellular Toxicology Book PDF

Author : Lesley Stanley
Publisher : John Wiley & Sons
Page : 471 pages
File Size : 50,5 Mb
Release : 2014-04-02
Category : Medical
ISBN : 9781118526019

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Molecular and Cellular Toxicology by Lesley Stanley Pdf

Toxicology is the study of the adverse effects of chemical, physical, or biological agents on people, animals, and the environment. Toxicologists are trained to investigate, interpret, and communicate the nature of those effects. Over the last ten years the subject of toxicology has changed dramatically, moving from a discipline which was once firmly wedded to traditional methods to one which is keen to embrace the innovative techniques emerging from the developing fields of cell culture and molecular biology. There is an acute need for this to be reflected in a paradigm shift which takes advantage of the opportunities offered by modern developments in the life sciences, including new in vitro and in silico approaches, alternative whole organism (non-mammalian) models and the exploitation of ‘omics methods, high throughput screening (HTS) techniques and molecular imaging technologies. This concise, accessible introduction to the field includes the very latest concepts and methodologies. It provides MSc, PhD and final year undergraduate students in pharmacy, biomedical and life sciences, as well as individuals starting out in the cosmetics, consumer products, pharmaceutical and testing industries, with everything they need to know to get to grips with the fast moving field of toxicology and the current approaches used in the risk assessment of drugs and chemicals.

Mechanistic Toxicology

Urs A. Boelsterli
Mechanistic Toxicology Book PDF

Author : Urs A. Boelsterli
Publisher : CRC Press
Page : 424 pages
File Size : 41,7 Mb
Release : 2007-03-23
Category : Medical
ISBN : 0849372720

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Mechanistic Toxicology by Urs A. Boelsterli Pdf

A thorough understanding of cellular and molecular mechanisms involved in the individual expression of toxic effects provides an important tool for assessment of human health risk. New aspects, major advances, and new areas in molecular and cellular biology and toxicology demand updated sources of information to elucidate the functional mechanics of human toxicology. Mechanistic Toxicology: The Molecular Basis of How Chemicals Disrupt Biological Targets, Second Edition retains the accessible format of the original to present the general principles that link xenobiotic-induced toxicity with the molecular pathways that underlie these toxic effects. Extensively illustrated, this book forms a conceptual bridge between multiple events at the molecular level and the determinants of toxicity at the physiological and cellular level. Specific examples of drugs, environmental pollutants, and other chemicals are carefully chosen to illustrate and highlight the fundamental mechanisms of toxicity at different toxicokinetic and toxicodynamic levels. The book includes references and review articles at the end of each chapter, as well as boxed text for relevant review information on biological, biochemical, molecular, and toxicological background. Linking molecular pathways to more general biomedical contexts, the author ensures that the reader is not lost in the details and instead receives a broad understanding of the processes underlying xenobiotic toxicity. New in the Second Edition Updated chapters Types of toxic responses Disruption of signal transduction by xenobiotics Disruption of mitochondrial function Novel mechanisms derived from systems toxicology

Molecular Toxicology Protocols

Phouthone Keohavong,Stephen G. Grant
Molecular Toxicology Protocols Book PDF

Author : Phouthone Keohavong,Stephen G. Grant
Publisher : Springer Science & Business Media
Page : 478 pages
File Size : 41,9 Mb
Release : 2008-02-03
Category : Medical
ISBN : 9781592598403

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Molecular Toxicology Protocols by Phouthone Keohavong,Stephen G. Grant Pdf

A collection of cutting-edge techniques for analyzing genotoxic exposure and detecting the resulting biological effects-including endogenous metabolites-up to and including the development of cancer. The authors emphasize analytical methods that can be specifically applied to human populations and patients. Among the applications detailed are the analysis of interactions between such cellular macromolecules as DNA and proteins and chemical and physical agents, the assessment of medically relevant toxicity, and the characterization of genetic alterations induced in transgenic animals by in vivo systems. There are also methods for the analysis of genotoxic exposure during gene expression, of cytotoxicity caused by the induction of apoptosis, of genetic alterations in reporter genes and oncogenes, early (premalignant) detection of altered oncogenes, and of individual variation in biotransformation and DNA repair capacity.

In Vitro Toxicology, Second Edition

Shayne C. Gad
In Vitro Toxicology Second Edition Book PDF

Author : Shayne C. Gad
Publisher : CRC Press
Page : 419 pages
File Size : 53,5 Mb
Release : 2000-11-02
Category : Medical
ISBN : 9781560327691

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In Vitro Toxicology, Second Edition by Shayne C. Gad Pdf

Toxicology has made tremendous strides in the sophistication of the models used to identify and understand the mechanisms of agents that can harm or kill humand and other higher organisms. Non-animals or in vitro models started to gain significant use in the 1960s. As a result of the increased concern over animal welfare, economic factors, and the need for greater sensitivity and understanding of mechanisms, interest in in vitro^n models has risen. This volume demonstrates that there now exists a broad range of in vitro models for use in either identifying or understanding most forms of toxicity. The availability of in vitro models spans both the full range of endpoints (irritation, sensitization, lethality, mutagenicity, and devlopmental toxicity) and the full spectrum of target organ systems (skin, eye, heart, liver, kidney, nervous system, etc.). Chapters are devoted to each of these speciality areas from a perspective of presenting the principal models and their uses and limitations. Chapters that overview the principles involved in the general selection and use of models, and that address the issues of safety concerns and regulatory acceptance of these methods are also included.

Molecular and Cellular Methods in Developmental Toxicology

George P. Daston
Molecular and Cellular Methods in Developmental Toxicology Book PDF

Author : George P. Daston
Publisher : CRC Press
Page : 336 pages
File Size : 40,9 Mb
Release : 2019-04-30
Category : Medical
ISBN : 9781439810668

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Molecular and Cellular Methods in Developmental Toxicology by George P. Daston Pdf

This new manual provides a convenient source of experimental procedures, including the most modern and frequently used molecular and cellular techniques. Experimental protocols have been carefully selected by developmental toxicologists for developmental toxicologists. The most important new trends, such as evaluation of the safety of therapeutic antisense oligonucleotides, studies of the role of cell death in abnormal development, and the identification of sparingly expressed developmental control genes are featured. This is the perfect manual for scientists trained in classical developmental toxicology who want to add molecular and cellular methods to their research.