Mucoadhesive Materials And Drug Delivery Systems

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Mucoadhesive Materials and Drug Delivery Systems

Vitaliy V. Khutoryanskiy
Mucoadhesive Materials and Drug Delivery Systems Book PDF

Author : Vitaliy V. Khutoryanskiy
Publisher : John Wiley & Sons
Page : 424 pages
File Size : 45,8 Mb
Release : 2014-06-12
Category : Science
ISBN : 9781118794395

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Mucoadhesive Materials and Drug Delivery Systems by Vitaliy V. Khutoryanskiy Pdf

Mucoadhesion defined as attachment of synthetic or natural materials to mucosal tissues has been widely exploited in pharmaceutical forms. This multi-author book provides an up-to-date account of current research on mucoadhesive materials and drug delivery systems. The introductory section describes the structure and physiology of various mucosal surfaces (oral, nasal, ocular, gastrointestinal and vaginal mucosa). This is followed by chapters on the various methods used to study mucoadhesion and to characterise mucoadhesive properties of various dosage forms. The final section will summarise information on traditional and novel types of mucoadhesive materials, such as chitosan, thiomers, and liposome-based formulations. This book is unique as there is currently no modern book considering mucoadhesion - all other existing books on the topic are either narrowly focused or more than 10 years old. Furthermore, each contributor offers specialist perspectives from a variety of global locations in both industrial and academic research centres.

Bioadhesive Drug Delivery Systems

Edith Mathiowitz,Donald E. Chickering III,Claus-Michael Lehr
Bioadhesive Drug Delivery Systems Book PDF

Author : Edith Mathiowitz,Donald E. Chickering III,Claus-Michael Lehr
Publisher : CRC Press
Page : 704 pages
File Size : 41,7 Mb
Release : 1999-07-13
Category : Medical
ISBN : 1420001345

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Bioadhesive Drug Delivery Systems by Edith Mathiowitz,Donald E. Chickering III,Claus-Michael Lehr Pdf

This invaluable reference presents a comprehensive review of the basic methods for characterizing bioadhesive materials and improving vehicle targeting and uptake-offering possibilities for reformulating existing compounds to create new pharmaceuticals at lower development costs. Evaluates the unique carrier characteristics of bioadhesive polymers and their power to enhance localization of delivered agents, local bioavailability, and drug absorption and transport! Written by over 50 international experts and reflecting broad knowledge of both traditional bioadhesive strategies and novel clinical applications, Bioadhesive Drug Delivery Systems discusses mechanical and chemical bonding, polymer-mucus interactions, the effect of surface energy in bioadhesion, polymer hydration, and mucus rheology analyzes biochemical properties of mucus and glycoproteins, cell adhesion molecules, and cellular interaction with two- and three-dimensional surfaces covers microbalances and magnetic force transducers, atomic force microscopy, direct measurements of molecular level adhesions, and methods to measure cell-cell interactions examines bioadhesive carriers, diffusion or penetration enhancers, and lectin-targeted vehicles describes vaginal, nasal, buccal, ocular, and transdermal drug delivery reviews bioadhesive interactions with the mucosal tissues of the eye and mouth, and those in the respiratory, urinary, and gastrointestinal tracts explores issues of product development, clinical testing, and production and more! Amply referenced with over 1400 bibliographic citations, and illustrated with more than 300 drawings, photographs, tables, and display equations, Bioadhesive Drug Delivery Systems serves as a sound basis for innovation in bioadhesive systems and an excellent introduction to the subject. This unique reference is ideal for pharmaceutical scientists and technologists; chemical, polymer, and plastics engineers; biochemists; physical, surface, and colloid chemists; biologists; and upper-level undergraduate and graduate students in these disciplines.

Advances in Mucoadhesive Polymers and Formulations for Transmucosal Drug Delivery

Vitaliy V. Khutoryanskiy
Advances in Mucoadhesive Polymers and Formulations for Transmucosal Drug Delivery Book PDF

Author : Vitaliy V. Khutoryanskiy
Publisher : MDPI
Page : 206 pages
File Size : 50,7 Mb
Release : 2020-04-22
Category : Medical
ISBN : 9783039287529

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Advances in Mucoadhesive Polymers and Formulations for Transmucosal Drug Delivery by Vitaliy V. Khutoryanskiy Pdf

Mucoadhesive polymers are widely used in the design of dosage forms for transmucosal drug delivery to the eye, respiratory, gastrointestinal and reproductive tracts. These routes of drug administration offer a number of advantages including improved drug bioavailability, reduced frequency of administration, and the avoidance for the use of injections. This book represents a collection of reviews and original research articles in the area of mucoadhesive polymers and dosage forms. It covers the design of mucoadhesive forms from commercially-available water-soluble polymers, their mixture and complexes as well as some materials, whose mucoadhesive properties were enhanced through chemical modification. With contributions from leading experts in mucoadhesive polymers and formulations, this book will be a very useful source of information for researchers in polymer, pharmaceutical and formulation sciences.

Bioadhesives in Drug Delivery

K. L. Mittal,Inderbir Singh Bakshi,Jasjit Kaur Narang
Bioadhesives in Drug Delivery Book PDF

Author : K. L. Mittal,Inderbir Singh Bakshi,Jasjit Kaur Narang
Publisher : John Wiley & Sons
Page : 432 pages
File Size : 45,8 Mb
Release : 2020-05-26
Category : Technology & Engineering
ISBN : 9781119640264

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Bioadhesives in Drug Delivery by K. L. Mittal,Inderbir Singh Bakshi,Jasjit Kaur Narang Pdf

This important and unique book comprises 12 chapters divided into three parts examining the fundamental aspects, bioadhesive formulations, and drug delivery applications. Understanding the phenomenon of bioadhesion i.e. its theories or mechanism(s) are of critical importance in developing optimum bioadhesive polymers (used in bioadhesives). Such bioadhesive polymers are the key for exhibiting the process of bioadhesion, controlled/sustained release of drugs, and drug targeting. The use of bioadhesives restricts the delivery system to the site of interest and thus offers a useful and efficient technique for targeting a drug to the desired location for a prolonged duration. This book addresses the various relevant aspects of bioadhesives in drug delivery in an easily accessible and unified manner. The book containing 12 chapters written by eminent researchers from many parts of the globe is divided into three parts: Part 1: Fundamental Aspects; Part 2: Bioadhesive Formulations; Part 3: Drug Delivery Applications. The topics covered include: Theories and mechanisms of bioadhesion; bioadhesive polymers for drug delivery applications; methods for characterization of bioadhesiveness of drug delivery systems; bioadhesive films and drug delivery applications; bioadhesive nanoparticles; bioadhesive hydrogels and applications; ocular biodhesive drug delivery systems; buccal bioadhesive drug delivery systems; gastrointestinal bioadhesive drug delivery systems; nasal bioadhesive drug delivery systems; vaginal drug delivery systems; pulmonary bioadhesive drug delivery systems.

Novel Drug Delivery Systems and Regulatory Affairs

Sudhakar Yajaman & Jayaveera K.N.
Novel Drug Delivery Systems and Regulatory Affairs Book PDF

Author : Sudhakar Yajaman & Jayaveera K.N.
Publisher : S. Chand Publishing
Page : 128 pages
File Size : 47,8 Mb
Release : 2014
Category : Medical
ISBN : 9788121942577

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Novel Drug Delivery Systems and Regulatory Affairs by Sudhakar Yajaman & Jayaveera K.N. Pdf

Novel Drug Delivery Systems | Transdermal Drug Delivery Systems | Mucoadhesive Drug Delivery Systems | Targeted Drugdelivery Systems | Regulatory Agencies | Quality Assurance | Good Manufacturing Practices | Validation

Oral Mucosal Drug Delivery and Therapy

Michael J. Rathbone,Sevda Senel,Indiran Pather
Oral Mucosal Drug Delivery and Therapy Book PDF

Author : Michael J. Rathbone,Sevda Senel,Indiran Pather
Publisher : Springer
Page : 289 pages
File Size : 47,6 Mb
Release : 2015-03-13
Category : Medical
ISBN : 9781489975584

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Oral Mucosal Drug Delivery and Therapy by Michael J. Rathbone,Sevda Senel,Indiran Pather Pdf

This volume provides a comprehensive overview of the current issues facing scientists working on delivering drugs locally and systemically via the membranes that line the mouth. The book describes the anatomical and physiological challenges of this route for drug delivery and how they impact the design of oral mucosal drug delivery systems. It also provides a detailed description of current oral mucosal drug delivery technologies that overcome these challenges alongside research, development and assessment methods. In 11 authoritative chapters, the book affords an in-depth evaluation of the major issues associated with this route of administration, namely the retention of the drug/product at the site of administration and increasing drug permeability through the oral mucosa. The book provides insights into the in vitro and in vivo methods available to assess drug permeability and retention, offers solutions on how to improve the permeation of the drugs through the oral mucosa, and explores approaches to prolong drug/product retention at the site of administration. It also indicates future directions in research and product development. Oral Mucosal Drug Delivery and Therapy is a key resource for those wishing to extend their knowledge of this field.

Mucoadhesive Drug Delivery System

Avinash Hosmani,Pramod Kasture,Yogesh Thorat
Mucoadhesive Drug Delivery System Book PDF

Author : Avinash Hosmani,Pramod Kasture,Yogesh Thorat
Publisher : LAP Lambert Academic Publishing
Page : 372 pages
File Size : 43,8 Mb
Release : 2013
Category : Electronic
ISBN : 3659415685

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Mucoadhesive Drug Delivery System by Avinash Hosmani,Pramod Kasture,Yogesh Thorat Pdf

In the recent days, the technology of Mucoadhesive drug delivery system has gained so much attention from the researchers in the field of formulation development. The drug delivery system enables the formulator to bring the drug in the close proximity to the mucus membrane with enhanced contact time and contact area. Thus the technology has been successful to bring out benefits like bio-availability enhancement along with the extended release. The book gives the idea about the basic fundamentals of Mucoadhesive systems. From the presented work, one may get information about the properties of mucoadhesive polymers. One may study the formulation of different mucoadhesive drug delivery systems like tablet, suspension and microsphere.

Handbook of Polyester Drug Delivery Systems

M. N. V. Ravi Kumar
Handbook of Polyester Drug Delivery Systems Book PDF

Author : M. N. V. Ravi Kumar
Publisher : CRC Press
Page : 401 pages
File Size : 40,8 Mb
Release : 2017-03-27
Category : Medical
ISBN : 9781315341163

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Handbook of Polyester Drug Delivery Systems by M. N. V. Ravi Kumar Pdf

In the quest for innovative drug delivery systems attempting to meet the unmet needs in pharmaceutical space, research has taken a much more complicated path that poses a significant challenge for translation. Despite the progress made with novel materials, polyesters still remain at the helm of drug delivery technologies. This book provides a single source of reference of polyester drug delivery systems that covers a broad spectrum of materials design, manufacturing techniques, and applications.

Recent Advances in Novel Drug Carrier Systems

Ali Demir Sezer
Recent Advances in Novel Drug Carrier Systems Book PDF

Author : Ali Demir Sezer
Publisher : BoD – Books on Demand
Page : 516 pages
File Size : 52,5 Mb
Release : 2012-10-31
Category : Medical
ISBN : 9789535108108

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Recent Advances in Novel Drug Carrier Systems by Ali Demir Sezer Pdf

This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.

Chemical Aspects of Drug Delivery Systems

D R Karsa,R A Stephenson
Chemical Aspects of Drug Delivery Systems Book PDF

Author : D R Karsa,R A Stephenson
Publisher : Royal Society of Chemistry
Page : 172 pages
File Size : 48,6 Mb
Release : 2007-10-31
Category : Medical
ISBN : 9781847550378

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Chemical Aspects of Drug Delivery Systems by D R Karsa,R A Stephenson Pdf

Despite advances in the development of new drugs, a drug may never reach the target organ, or it may be difficult to achieve the necessary level of drug in the body. Large doses can result in serious side effects and can harm normal, as well as diseased, cells and organs, and for this reason it is vital that controlled release and the targeting of delivery systems must evolve in parallel to drug research. Chemical Aspects of Drug Delivery Systems reflects the modern challenge to devise effective drug delivery and targeting systems, giving particular emphasis to recent innovations in the field. Delivery systems described include carbohydrate derivatives, novel nonionic surfactant vesicles and various polymers, including polyacrylates and aqueous shellac solutions, as well as hydrogels. In addition, many of the key issues, such as the understanding of biosystems and targets and the development of materials to provide the deserved carrier and excipient properties for controlled, targeted drug delivery, are considered in depth. This book will be of equal interest to undergraduate, graduate, researcher and those in the pharmaceutical industries, and it complements two previous RSC Special Publications, Encapsulation and Controlled Release and Excipients and Delivery Systems for Pharmaceutical Formulations.

Fundamentals of Drug Delivery

Michael S. Roberts,Heather A. E. Benson,Adrian C. Williams,Xiaowen Liang
Fundamentals of Drug Delivery Book PDF

Author : Michael S. Roberts,Heather A. E. Benson,Adrian C. Williams,Xiaowen Liang
Publisher : John Wiley & Sons
Page : 580 pages
File Size : 49,9 Mb
Release : 2021-09-30
Category : Medical
ISBN : 9781119769675

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Fundamentals of Drug Delivery by Michael S. Roberts,Heather A. E. Benson,Adrian C. Williams,Xiaowen Liang Pdf

A comprehensive guide to the current research, major challenges, and future prospects of controlled drug delivery systems Controlled drug delivery has the potential to significantly improve therapeutic outcomes, increase clinical benefits, and enhance the safety of drugs in a wide range of diseases and health conditions. Fundamentals of Drug Delivery provides comprehensive and up-to-date coverage of the essential principles and processes of modern controlled drug delivery systems. Featuring contributions by respected researchers, clinicians, and pharmaceutical industry professionals, this edited volume reviews the latest research in the field and addresses the many issues central to the development of effective, controlled drug delivery. Divided in three parts, the book begins by introducing the concept of drug delivery and discussing both challenges and opportunities within the rapidly evolving field. The second section presents an in-depth critique of the common administration routes for controlled drug delivery, including delivery through skin, the lungs, and via ocular, nasal, and otic routes. The concluding section summarizes the current state of the field and examines specific issues in drug delivery and advanced delivery technologies, such as the use of nanotechnology in dermal drug delivery and advanced drug delivery systems for biologics. This authoritative resource: Covers each main stage of the drug development process, including selecting pharmaceutical candidates and evaluating their physicochemical characteristics Describes the role and application of mathematical modelling and the influence of drug transporters in pharmacokinetics and drug disposition Details the physiology and barriers to drug delivery for each administration route Presents a historical perspective and a look into the possible future of advanced drug delivery systems Explores nanotechnology and cell-mediated drug delivery, including applications for targeted delivery and toxicological and safety issues Includes comprehensive references and links to the primary literature Edited by a team of of internationally-recognized experts, Fundamentals of Drug Delivery is essential reading for researchers, industrial scientists, and advanced students in all areas of drug delivery including pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.

Nanopharmaceutical Advanced Delivery Systems

Vivek Dave,Nikita Gupta,Srija Sur
Nanopharmaceutical Advanced Delivery Systems Book PDF

Author : Vivek Dave,Nikita Gupta,Srija Sur
Publisher : John Wiley & Sons
Page : 467 pages
File Size : 49,5 Mb
Release : 2020-12-29
Category : Computers
ISBN : 9781119711681

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Nanopharmaceutical Advanced Delivery Systems by Vivek Dave,Nikita Gupta,Srija Sur Pdf

The book provides a single volume covering detailed descriptions about various delivery systems, their principles and how these are put in use for the treatment of multiple diseases. It is divided into four sections where the first section deals with the introduction and importance of novel drug delivery system. The second section deals with the most advanced drug delivery systems like microbubbles, dendrimers, lipid-based nanoparticles, nanofibers, microemulsions etc., describing the major principles and techniques of the preparations of the drug delivery systems. The third section elaborates on the treatments of diverse diseases like cancer, topical diseases, tuberculosis etc. The fourth and final section provides a brief informative description about the regulatory aspects of novel drug delivery system that is followed in various countries.

Drug Delivery

Eric P. Holowka,Sujata K. Bhatia
Drug Delivery Book PDF

Author : Eric P. Holowka,Sujata K. Bhatia
Publisher : Springer
Page : 0 pages
File Size : 55,5 Mb
Release : 2016-09-22
Category : Technology & Engineering
ISBN : 1493946048

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Drug Delivery by Eric P. Holowka,Sujata K. Bhatia Pdf

Current pharmaceutical and clinical approaches to the treatment of disease suffer from the inherent limitations in the specialization of drugs introduced to physiological systems. The interface of clinical and material sciences has allowed for a broad spectrum of creative approaches with the potential to alleviate these shortcomings. However, the synergy of these disciplines also presents problems in which nascent technology lacks the necessary evaluation within its intended clinical environment. Given the growing potential for materials science to address a number of unanswered therapeutic needs, it remains even more pressing to validate emerging drug delivery technologies in actual clinical environments. Drug Delivery: Materials Design and Clinical Perspective addresses the core fundamentals of drug delivery using material science and engineering principles, and then applies this knowledge using prominent examples from both the scientific literature and clinical practice. Each chapter focuses on a specific drug delivery technology, such as controlled-release materials, thin-film materials, or smart materials. Within each chapter, an initial section on “Engineering Concepts” reviews the relevant fundamental principles that guide rational design. The following section on “Materials Design” discusses how the design process applies engineering concepts for use in physiological systems. A third section on “Implementation” discusses current approaches in the literature which have demonstrated effective drug delivery in controlled environments. Finally, each chapter contains several sections on “Clinical Applications” which describe the validity of materials approaches from a clinical perspective; these sections review the safety and efficacy of drug delivery systems for specific, compelling medical applications. The book thereby bridges materials science with clinical medicine, and provides the reader with a bench-to-bedside view of novel drug delivery systems. · Provides a comprehensive description of drug delivery systems from a materials perspective · Includes a wide-ranging discussion of clinical applications of drug delivery systems · Presents separate chapters on controlled release materials, thin film materials, self-microemulsifying materials, smart materials, etc. · Covers fundamental engineering principles, rational materials design, implementation testing, and clinical applications for each material type

Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes

Vijay Mishra,Prashant Kesharwani,Mohd Cairul Iqbal Mohd Amin,Arun Iyer
Nanotechnology Based Approaches for Targeting and Delivery of Drugs and Genes Book PDF

Author : Vijay Mishra,Prashant Kesharwani,Mohd Cairul Iqbal Mohd Amin,Arun Iyer
Publisher : Academic Press
Page : 552 pages
File Size : 47,8 Mb
Release : 2017-05-23
Category : Medical
ISBN : 9780128097182

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Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes by Vijay Mishra,Prashant Kesharwani,Mohd Cairul Iqbal Mohd Amin,Arun Iyer Pdf

Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes provides an overview of the important aspects of nanomedicine in order to illustrate how to design and develop novel and effective drug delivery systems using nanotechnology. The book is organized into three sections, beginning with an introduction to nanomedicine and its associated issues. Section two discusses the latest technologies in nanomedicine, while the third section covers future developments and challenges in the field. By focusing on the design, synthesis, and application of a variety of nanocarriers in drug and gene delivery, this book provides pharmaceutical and materials science students, professors, clinical researchers, and industry scientists with a valuable resource aimed at tackling the challenges of delivering drugs and genes in a more targeted manner. Explores a wide range of promising approaches for the diagnosis and treatment of diseases using the latest advances in cutting-edge nanomedical technologies Contains contributions from world-renowned experts and researchers working in the area of nanomedicine and drug delivery Covers the associated challenges and potential solutions to working with nanotechnology in drug delivery Highlights crucial topics, such as biopharmaceutical and toxicity issues, quality by design, drug targeting, and more

Engineering Polymer Systems for Improved Drug Delivery

Rebecca A. Bader,David A. Putnam
Engineering Polymer Systems for Improved Drug Delivery Book PDF

Author : Rebecca A. Bader,David A. Putnam
Publisher : John Wiley & Sons
Page : 395 pages
File Size : 50,6 Mb
Release : 2014-01-17
Category : Social Science
ISBN : 9781118747803

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Engineering Polymer Systems for Improved Drug Delivery by Rebecca A. Bader,David A. Putnam Pdf

Polymers have played a critical role in the rational design and application of drug delivery systems that increase the efficacy and reduce the toxicity of new and conventional therapeutics. Beginning with an introduction to the fundamentals of drug delivery, Engineering Polymer Systems for Improved Drug Delivery explores traditional drug delivery techniques as well as emerging advanced drug delivery techniques. By reviewing many types of polymeric drug delivery systems, and including key points, worked examples and homework problems, this book will serve as a guide to for specialists and non-specialists as well as a graduate level text for drug delivery courses.