Natural Products In Chemical Biology

Author : Natanya Civjan
Publisher : John Wiley & Sons
Page : 437 pages
File Size : 52,6 Mb
Release : 2012-07-03
Category : Science
ISBN : 9781118101179

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Natural Products in Chemical Biology by Natanya Civjan Pdf

Based on the award winning Wiley Encyclopedia of Chemical Biology, this book provides a general overview of the unique features of the small molecules referred to as "natural products", explores how this traditionally organic chemistry-based field was transformed by insights from genetics and biochemistry, and highlights some promising future directions. The book begins by introducing natural products from different origins, moves on to presenting and discussing biosynthesis of various classes of natural products, and then looks at natural products as models and the possibilities of using them in medicine.

Author : David J. Newman,Gordon M. Cragg,Paul Grothaus
Publisher : CRC Press
Page : 622 pages
File Size : 43,9 Mb
Release : 2017-09-22
Category : Medical
ISBN : 9781351643283

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Chemical Biology of Natural Products by David J. Newman,Gordon M. Cragg,Paul Grothaus Pdf

Chemical Biology of Natural Products This unique, long-awaited volume is designed to address contemporary aspects of natural product chemistry and its influence on biological systems, not solely on human interactions. The subjects covered include discovery, isolation and characterization, biosynthesis, biosynthetic engineering, pharmaceutical, and other applications of these compounds. Each chapter begins with a brief and simple introduction to the subject matter, and then proceeds to guide the reader towards the more contemporary, cutting-edge research in the field, with the contributing authors presenting current examples from their own work in order to exemplify key themes. Topics covered in the text include genome mining, heterologous expression, natural product synthesis, biosynthesis, glycosylation, chemical ecology, and therapeutic applications of natural products, both current and potential.

Author : Anonim
Publisher : Elsevier
Page : 4266 pages
File Size : 47,9 Mb
Release : 2020-07-22
Category : Science
ISBN : 9780081026915

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Comprehensive Natural Products III by Anonim Pdf

Comprehensive Natural Products III, Third Edition, Seven Volume Set updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community. Provides readers with an in-depth review of current natural products research and a critical insight into the future direction of the field Bridges the gap in knowledge by covering developments in the field since the second edition published in 2010 Split into 7 sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Ensures that the knowledge within is easily understood by and applicable to a large audience

Author : Goutam Brahmachari
Publisher : John Wiley & Sons
Page : 544 pages
File Size : 54,5 Mb
Release : 2015-03-23
Category : Science
ISBN : 9783527337941

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Bioactive Natural Products by Goutam Brahmachari Pdf

Natural compounds, which have evolved their function over millions of years, are often more efficient than man-made compounds if a specific biological activity is needed, e.g. as an enzyme inhibitor or as a toxin to kill a cancer cell. This book comprising of sixteen technical chapters, highlights the chemical and biological aspects of potential natural products with an intention of unravelling their pharmaceutical applicability in modern drug discovery processes. Key features: Covers the synthesis, semi-synthesis and also biosynthesis of potentially bioactive natural products Features chemical and biological advances in naturally occurring organic compounds describing their chemical transformations, mode of actions, and structure-activity relationships 40 expert scientists from around the world report their latest findings and outline future opportunities for the development of novel and highly potent drugs based on natural products operating at the interface of chemistry and biology Forward-looking: Addresses opportunities and cutting-edge developments rather than well-documented basic knowledge, pinpoints current trends and future directions in this rapidly-evolving field Application-oriented: Throughout the book, the focus is on actual and potential applications in pharmacology and biotechnology This book is an essential resource for natural products chemists, medicinal chemists, biotechnologists, biochemists, pharmacologists, as well as the pharmaceutical and biotechnological industries.

Author : Anonim
Publisher : Elsevier
Page : 7944 pages
File Size : 49,7 Mb
Release : 2010-03-05
Category : Science
ISBN : 9780080453828

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Comprehensive Natural Products II by Anonim Pdf

This work presents a definitive interpretation of the current status of and future trends in natural products—a dynamic field at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids, and enzymes. With more than 1,800 color figures, Comprehensive Natural Products II features 100% new material and complements rather than replaces the original work (©1999). Reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine Stimulates new ideas among the established natural products research community—which includes chemists, biochemists, biologists, botanists, and pharmacologists Informs and inspires students and newcomers to the field with accessible content in a range of delivery formats Includes 100% new content, with more than 6,000 figures (1/3 of these in color) and 40,000 references to the primary literature, for a thorough examination of the field Highlights new research and innovations concerning living organisms and their distinctive role in our understanding and improvement of human health, genomics, ecology/environment, and more Adds to the rich body of work that is the first edition, which will be available for the first time in a convenient online format giving researchers complete access to authoritative Natural Products content

Author : Raymond Cooper,George Nicola
Publisher : CRC Press
Page : 210 pages
File Size : 47,6 Mb
Release : 2014-07-29
Category : Medical
ISBN : 9781466567610

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Natural Products Chemistry by Raymond Cooper,George Nicola Pdf

Notoriously cumbersome to isolate and challenging to synthesize, the path of natural products to viable drugs is an arduous journey. Yet compounds isolated from nature may possess fascinating structures, biological profiles and pharmaceutical potential far greater than anything made by man. Natural Products Chemistry: Sources, Separations and Structures presents a practical guide to sourcing, isolating, and discovering new compounds from nature many of which become pharmaceutical drugs. This book emphasizes the challenges and advantages of products acquired from nature, compared to those obtained from combinatorial chemistry. A basic introduction, the book describes the whole cycle from farm to final compound, backed up by case studies drawn from industry and research applications. It broadens the scope of applications and draws upon examples from various sources. Natural products chemistry, as taught today, draws its examples mainly from marine chemistry or plant chemistry; however, there is also a fascinating and rich world of fermented (microbial and algal) products leading to complex structures. Thus, the book draws upon examples from the microbial world and from insects too. Therefore, this is a source of bioactive metabolites, not traditionally available in academic settings, more the mainstay of the pharmaceutical industry. Providing a roadmap of the process of collecting a compound from nature, isolating the active ingredient, and determining the chemical structure, this book provides a unique approach to the world of natural products.

Author : Olga Genilloud,Francisca Vicente
Publisher : Royal Society of Chemistry
Page : 435 pages
File Size : 50,8 Mb
Release : 2012
Category : Medical
ISBN : 9781849733618

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Drug Discovery from Natural Products by Olga Genilloud,Francisca Vicente Pdf

An integrated review of the most recent trends in natural products, drug discovery, and key lead candidates that are outstanding for their chemistry and biology in novel drug development.

Author : Antony D. Buss,Mark S. Butler
Publisher : Royal Society of Chemistry
Page : 459 pages
File Size : 51,8 Mb
Release : 2010
Category : Medical
ISBN : 9780854041930

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Natural Product Chemistry for Drug Discovery by Antony D. Buss,Mark S. Butler Pdf

This text provides a comprehensive summary of where natural product chemistry is today in drug discovery. It covers emerging technologies and case studies and is a source of up-to-date information on the topical subject of natural products.

Author : J. Mann
Publisher : Longman Publishing Group
Page : 502 pages
File Size : 41,7 Mb
Release : 1994
Category : Biochemistry
ISBN : UCSD:31822020600318

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Natural Products by J. Mann Pdf

An account of the structure, chemistry, biosynthesis, and biological activity of most types of organic compounds, with each chapter devoted to classes of compounds, such as carbohydrates, nucleotides and polynucleotides, fatty acids, terpenoids, phenolics, and alkaloids. Includes numerous bandw diagrams. An excellent complement to a standard text on basic organic chemistry. For senior undergraduates and graduate students of organic and medicinal chemistry, biochemistry, pharmacy, and pharmacology. Annotation copyright by Book News, Inc., Portland, OR

Author : Sujata V. Bhat,B.A. Nagasampagi,Meenakshi Sivakumar
Publisher : Springer Science & Business Media
Page : 886 pages
File Size : 55,6 Mb
Release : 2005-01-04
Category : Science
ISBN : 3540406697

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Chemistry of Natural Products by Sujata V. Bhat,B.A. Nagasampagi,Meenakshi Sivakumar Pdf

During the last few decades, research into natural products has advanced tremendously thanks to contributions from the fields of chemistry, life sciences, food science and material sciences. Comparisons of natural products from microorganisms, lower eukaryotes, animals, higher plants and marine organisms are now well documented. This book provides an easy-to-read overview of natural products. It includes twelve chapters covering most of the aspects of natural products chemistry. Each chapter covers general introduction, nomenclature, occurrence, isolation, detection, structure elucidation both by degradation and spectroscopic techniques, biosynthesis, synthesis, biological activity and commercial applications, if any, of the compounds mentioned in each topic. Therefore it will be useful for students, other researchers and industry. The introduction to each chapter is brief and attempts only to supply general knowledge in the particular field. Furthermore, at the end of each chapter there is a list of recommended books for additional study and a list of relevant questions for practice.

Author : Nick J Westwood,Adam Nelson
Publisher : Royal Society of Chemistry
Page : 339 pages
File Size : 54,9 Mb
Release : 2018-08-16
Category : Science
ISBN : 9781788015073

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Chemical and Biological Synthesis by Nick J Westwood,Adam Nelson Pdf

Synthetic chemistry plays a central role in many areas of chemical biology; utilising recent case studies, the goal of Chemical and Biological Synthesis is to highlight the full impact that the preparation of novel reagents can have in chemical biology. Covering the synthetic approaches that can be applied across the whole field of chemical biology, this book provides synthetic chemists with the broader context to which their work contributes and the biological questions that can be addressed through it. An ideal guide for postgraduate students and researchers in synthetic organic chemistry and chemical biology, Chemical and Biological Synthesis introduces synthetic techniques and methods to those who wish to incorporate synthesis for the first time in their biology-focused research programmes.

Author : Hung-wen Liu,Tadhg P. Begley
Publisher : Unknown
Page : 0 pages
File Size : 52,5 Mb
Release : 2020
Category : Natural products
ISBN : 0128217081

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Comprehensive Natural Products III by Hung-wen Liu,Tadhg P. Begley Pdf

Author : Jie Jack Li,E.J. Corey
Publisher : Springer Science & Business Media
Page : 292 pages
File Size : 55,5 Mb
Release : 2013-03-14
Category : Science
ISBN : 9783642340659

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Total Synthesis of Natural Products by Jie Jack Li,E.J. Corey Pdf

'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry.

Author : Sunil Kumar Talapatra,Bani Talapatra
Publisher : Springer
Page : 1180 pages
File Size : 41,7 Mb
Release : 2015-03-05
Category : Science
ISBN : 9783642454103

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Chemistry of Plant Natural Products by Sunil Kumar Talapatra,Bani Talapatra Pdf

Aimed at advanced undergraduate and graduate students and researchers working with natural products, Professors Sunil and Bani Talapatra provide a highly accessible compilation describing all aspects of plant natural products. Beginning with a general introduction to set the context, the authors then go on to carefully detail nomenclature, occurrence, isolation, detection, structure elucidation (by both degradation and spectroscopic techniques) stereochemistry, conformation, synthesis, biosynthesis, biological activity and commercial applications of the most important natural products of plant origin. Each chapter also includes detailed references (with titles) and a list of recommended books for additional study making this outstanding treatise a useful resource for teachers of chemistry and researchers working in universities, research institutes and industry.

Author : Wenxu Zhou,De-an Guo
Publisher : MDPI
Page : 256 pages
File Size : 49,9 Mb
Release : 2019-06-05
Category : Science
ISBN : 9783038974161

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Chemical Biology of Sterols, Triterpenoids and Other Natural Products by Wenxu Zhou,De-an Guo Pdf

Sterols and other isoprenoids are of great interest for their molecular structure and function in cell architecture and evolution, as well as for their importance in medicine and agriculture. Molecules’ 2019 Festschrift Special Issue in honor of the 65th birthday of Prof. W. David Nes, an internationally recognized chemical biologist and recipient of the George Schroepher medal for sterol research, focuses on recent developments in the chemistry, biosynthesis, and function of these polycyclic natural products. This volume of Molecules contains 16 leading-edge review articles and original research contributions from an international cast of scientists. This volume is grouped into three sections: (i) isoprenoid metabolome and diversity, (ii) clinical evaluation of sterol and triterpene structures and biosynthesis, and (iii) methods and synthesis of steroids and other compounds. The volume will be a valuable reference tool for those who study medicinal chemistry, protein chemistry, and biochemistry of isoprenoid lipids.