Protein Amyloid Aggregation

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Protein Amyloid Aggregation

David Eliezer
Protein Amyloid Aggregation Book PDF

Author : David Eliezer
Publisher : Humana
Page : 0 pages
File Size : 47,8 Mb
Release : 2015-10-11
Category : Science
ISBN : 1493929771

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Protein Amyloid Aggregation by David Eliezer Pdf

This detailed volume focuses on methods for the characterization of aggregation processes that lead to the formation of amyloid fibrils and amyloid oligomers which feature in the etiology of a variety of human disorders collectively known as amyloidoses. The scope of the collection includes techniques for visualizing early steps on the amyloid formation pathway, methods for capturing and characterizing oligomeric, potentially toxic, intermediates, strategies for preparing and characterizing mature amyloid fibrils and approaches for understanding templating and transmission of amyloid aggregates. Written in the highly successful Methods in Molecular Biology series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Protein Amyloid Aggregation: Methods and Protocols serves as an ideal guide for biochemists and biophysicists with an interest in elucidating the mechanisms of protein amyloid formation, as well as chemists, pharmacologists and clinicians with an interest in leveraging an understanding of such mechanisms for the purpose of therapeutic development.

The Hidden World of Protein Aggregation

Anonim
The Hidden World of Protein Aggregation Book PDF

Author : Anonim
Publisher : Elsevier
Page : 530 pages
File Size : 44,8 Mb
Release : 2024-08-01
Category : Science
ISBN : 9780443293412

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The Hidden World of Protein Aggregation by Anonim Pdf

The Hidden World of Protein Aggregation, Volume 206 provides a comprehensive exploration of protein aggregation, uncovering the factors behind the formation of amorphous aggregates and ordered structures called amyloid fibrils. It delves into the advantages and disadvantages of protein aggregates, addressing topics such as cytotoxicity and disorders linked to misfolding. Specific chapters in this release include Protein Aggregation: An Overview, Pathways of Amyloid Fibril Formation and Aggregation, Factors Influencing Amyloid Fibril Formation, Morphological Features and Types of Aggregated Structures, Each big journey starts with a first step: Importance of Oligomerization, Liquid-Liquid Phase Separation as Triggering Factor of Fibril Formation, and more. Additional sections cover Experimental Techniques for Detecting and Evaluating the Amyloid Fibrils, Prediction of Protein Aggregation, Amyloid Fibril Cytotoxicity and Associated Disorders, Inhibitors of Amyloid Fibril Formation, Therapeutic Approaches in Proteinopathies, Functional Amyloids, Biotechnological Applications of Amyloid Fibrils, and The Hidden World of Protein Aggregation. Provides an introduction to the folding of protein and associated conditions leading to aggregation and linked pathology Discusses structural biology and computational methodologies for analysis of protein (mis)folding and aggregation Describes functional amyloids and their biotechnological applications

Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease

J. Robin Harris
Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease Book PDF

Author : J. Robin Harris
Publisher : Springer Science & Business Media
Page : 654 pages
File Size : 49,5 Mb
Release : 2012-12-09
Category : Medical
ISBN : 9789400754164

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Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease by J. Robin Harris Pdf

This volume of the Subcellular Biochemistry series is the result of the long-standing research interest of the editor in the molecular mechanism underlying Alzheimer’s disease and other amyloid diseases, indicated also by the earlier book in the series (Volume 38), devoted to Alzheimer’s disease. The broad coverage within the present amyloidogenesis book represents an attempt to collate current knowledge relating to the proteins and peptides involved in most of the known amyloid diseases, together with some amyloid/fibril-forming proteins and peptides that are not involved in diseases. Thus, the range of topics included is comprehensive and furthermore it was thought appropriate to include both basic science and clinical presentation of the subjects under discussion.

Biophysics And Biochemistry Of Protein Aggregation: Experimental And Theoretical Studies On Folding, Misfolding, And Self-assembly Of Amyloidogenic Peptides

Yuan Jian-min,Zhou Huan-xiang
Biophysics And Biochemistry Of Protein Aggregation Experimental And Theoretical Studies On Folding Misfolding And Self assembly Of Amyloidogenic Peptides Book PDF

Author : Yuan Jian-min,Zhou Huan-xiang
Publisher : World Scientific
Page : 328 pages
File Size : 53,5 Mb
Release : 2017-06-02
Category : Science
ISBN : 9789813202399

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Biophysics And Biochemistry Of Protein Aggregation: Experimental And Theoretical Studies On Folding, Misfolding, And Self-assembly Of Amyloidogenic Peptides by Yuan Jian-min,Zhou Huan-xiang Pdf

This book reviews current research on the important processes involved in neurodegenerative diseases (e.g. Alzheimer's disease) and the peptides and proteins involved in the amyloidogenic processes. It covers the design and developments of anti-amyloid inhibitors, and gives readers a fundamental understanding of the underlying oligomerization and aggregation processes of these diseases from both computational and experimental points of view.

Protein Misfolding, Aggregation and Conformational Diseases

Vladimir N. Uversky,Anthony Fink
Protein Misfolding Aggregation and Conformational Diseases Book PDF

Author : Vladimir N. Uversky,Anthony Fink
Publisher : Springer Science & Business Media
Page : 450 pages
File Size : 42,6 Mb
Release : 2007-11-24
Category : Science
ISBN : 9780387259192

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Protein Misfolding, Aggregation and Conformational Diseases by Vladimir N. Uversky,Anthony Fink Pdf

Research indicates that most neurodegenerative diseases, systemic amyloidoses and many others, arise from the misfolding and aggregation of an underlying protein. This is the first book to discuss significant achievements in protein structure-function relationships in biochemistry, molecular biology and molecular medicine. The authors summarize recent progress in the understanding of the relationships between protein misfolding, aggregation and development of protein deposition disorders.

Early Stage Protein Misfolding and Amyloid Aggregation

Anonim
Early Stage Protein Misfolding and Amyloid Aggregation Book PDF

Author : Anonim
Publisher : Academic Press
Page : 320 pages
File Size : 48,5 Mb
Release : 2017-02-01
Category : Science
ISBN : 9780128122525

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Early Stage Protein Misfolding and Amyloid Aggregation by Anonim Pdf

Early Stage Protein Misfolding and Amyloid Aggregation, Volume 329, the latest in the International Review of Cell and Molecular Biology series presents comprehensive reviews and current advances in cell and molecular biology, including articles that address the structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. The series has a worldwide readership and maintains a high standard by publishing invited articles on important and timely topics as authored by prominent cell and molecular biologists. Provides comprehensive reviews and current advances Presents a wide range of perspectives on specific subjects Includes valuable reference material for advanced undergraduates, graduate students, and professional scientists

Amyloid, Prions, and Other Protein Aggregates, Part C

Anonim
Amyloid Prions and Other Protein Aggregates Part C Book PDF

Author : Anonim
Publisher : Elsevier
Page : 412 pages
File Size : 43,9 Mb
Release : 2006-10-06
Category : Science
ISBN : 9780080468976

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Amyloid, Prions, and Other Protein Aggregates, Part C by Anonim Pdf

The ability of polypeptides to form alternatively folded, polymeric structures such as amyloids and related aggregates is being increasingly recognized as a major new frontier in protein research. This new volume of Methods in Enzymology along with Part B (volume 412) on Amyloid, Prions and other Protein Aggregates continue in the tradition of the first volume (309) in containing detailed protocols and methodological insights, provided by leaders in the field, into the latest methods for investigating the structures, mechanisms of formation, and biological activities of this important class of protein assemblies. Presents detailed protocols Includes troubleshooting tips Provides coverage on structural biology, computational methods, and biology

Protein Misfolding, Aggregation and Conformational Diseases

Vladimir N. Uversky,Anthony Fink
Protein Misfolding Aggregation and Conformational Diseases Book PDF

Author : Vladimir N. Uversky,Anthony Fink
Publisher : Springer Science & Business Media
Page : 538 pages
File Size : 49,6 Mb
Release : 2007-05-26
Category : Medical
ISBN : 9780387365343

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Protein Misfolding, Aggregation and Conformational Diseases by Vladimir N. Uversky,Anthony Fink Pdf

The second volume continues to fill the gap in protein review and protocol literature. It does this while summarizing recent achievements in the understanding of the relationships between protein misfoldings, aggregation, and development of protein deposition disorders. The focus of Part B is the molecular basis of differential disorders.

Biological Soft Matter

Corinne Nardin,Helmut Schlaad
Biological Soft Matter Book PDF

Author : Corinne Nardin,Helmut Schlaad
Publisher : John Wiley & Sons
Page : 288 pages
File Size : 51,9 Mb
Release : 2021-04-06
Category : Technology & Engineering
ISBN : 9783527810994

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Biological Soft Matter by Corinne Nardin,Helmut Schlaad Pdf

Biological Soft Matter Explore a comprehensive, one-stop reference on biological soft matter written and edited by leading voices in the field Biological Soft Matter: Fundamentals, Properties and Applications delivers a unique and indispensable compilation of up-to-date knowledge and material on biological soft matter. The book presents a thorough overview about biological soft matter, beginning with different substance classes, including proteins, nucleic acids, lipids, and polysaccharides. It goes on to describe a variety of superstructures and aggregated and how they are formed by self-assembly processes like protein folding or crystallization. The distinguished editors have included materials with a special emphasis on macromolecular assembly, including how it applies to lipid membranes, and proteins fibrillization. Biological Soft Matter is a crucial resource for anyone working in the field, compiling information about all important substance classes and their respective roles in forming superstructures. The book is ideal for beginners and experts alike and makes the perfect guide for chemists, physicists, and life scientists with an interest in the area. Readers will also benefit from the inclusion of: An introduction to DNA nano-engineering and DNA-driven nanoparticle assembly Explorations of polysaccharides and glycoproteins, engineered biopolymers, and engineered hydrogels Discussions of macromolecular assemblies, including liquid membranes and small molecule inhibitors for amyloid aggregation A treatment of inorganic nanomaterials as promoters and inhibitors of amyloid fibril formation An examination of a wide variety of natural and artificial polymers Perfect for materials scientists, biochemists, polymer chemists, and protein chemists, Biological Soft Matter: Fundamentals, Properties and Applications will also earn a place in the libraries of biophysicists and physical chemists seeking a one-stop reference summarizing the rapidly evolving topic of biological soft matter.

Amyloid, Prions, and Other Protein Aggregates

Anonim
Amyloid Prions and Other Protein Aggregates Book PDF

Author : Anonim
Publisher : Elsevier
Page : 861 pages
File Size : 46,7 Mb
Release : 1999-09-22
Category : Science
ISBN : 9780080496672

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Amyloid, Prions, and Other Protein Aggregates by Anonim Pdf

This volume includes a core of methodologies to attack the unique experimental problems presented by protein misassembly. Emphasis is on human biology applications, the area in which there is the most interest, in which most of the work has already been done, and in which there is the best evidence for the structural sophisitication of the protein aggregates.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

Amyloid Proteins

Einar M. Sigurdsson
Amyloid Proteins Book PDF

Author : Einar M. Sigurdsson
Publisher : Springer Science & Business Media
Page : 390 pages
File Size : 54,7 Mb
Release : 2008-02-02
Category : Science
ISBN : 9781592598748

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Amyloid Proteins by Einar M. Sigurdsson Pdf

A proven collection of readily reproducible techniques for studying amyloid proteins and their involvement in the etiology, pathogenesis, diagnosis, and therapy of amyloid diseases. The contributors provide methods for the preparation of amyloid and its precursors (oligomers and protofibrils), in vitro assays and analytical techniques for their study, and cell culture models and assays for the production of amyloid proteins. Additional chapters present readily reproducible techniques for amyloid extraction from tissue, its detection in vitro and in vivo, as well as nontransgenic methods for developing amyloid mouse models. The protocols follow the successful Methods in Molecular BiologyTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.

High Pressure NMR

Jiri Jonas
High Pressure NMR Book PDF

Author : Jiri Jonas
Publisher : Springer Science & Business Media
Page : 272 pages
File Size : 46,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642759260

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High Pressure NMR by Jiri Jonas Pdf

In recent years, there has been a major expansion of high pressure research providing unique information about systems of interest to a wide range of scientific disciplines. Since nuclear magnetic resonance has been applied to a wide spec trum of problems in chemistry, physics and biochemistry, it is not surprising to find that high pressure NMR techniques have also had many applications in these fields of science. Clearly, the high information content of NMR experiments combined with high pressure provides a powerful tool in modern chem istry. It is the aim of this monograph, in the series on NMR Basic Principles and Progress, to illustrate the wide range of prob lems which can be successfully studied by high pressure NMR. Indeed, the various contributions in this volume discuss studies of interest to physics, chemical physics, biochemistry, and chemical reaction kinetics. In many different ways, this monograph demonstrates the power of modern experimental and theoretical techniques to investigate very complex systems. The first contribution, by D. Brinkman, deals with NMR and NQR studies of superionic conductors and high-Tc supercon ductors at high pressure. Pressure effects on phase transitions, detection of new phases, and pressure effects on diffusion and spin-lattice relaxation, represent a few of the topics discussed in this contribution of particular interest to solid state physics.

Computer Simulations of Aggregation of Proteins and Peptides

Mai Suan Li,Andrzej Kloczkowski,Marek Cieplak,Maksim Kouza
Computer Simulations of Aggregation of Proteins and Peptides Book PDF

Author : Mai Suan Li,Andrzej Kloczkowski,Marek Cieplak,Maksim Kouza
Publisher : Humana
Page : 478 pages
File Size : 50,9 Mb
Release : 2022-02-16
Category : Science
ISBN : 1071615459

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Computer Simulations of Aggregation of Proteins and Peptides by Mai Suan Li,Andrzej Kloczkowski,Marek Cieplak,Maksim Kouza Pdf

This volume provides computational methods and reviews various aspects of computational studies of protein aggregation. Chapters discuss the relationship between protein misfolding and protein aggregation, methods of prediction of aggregation propensities of protein, peptides, protein structure, results of computer simulations of aggregation, and computational simulations focused on specific diseases such as Alzheimer’s, Parkinson’s, and preeclampsia. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Computer Simulations of Aggregation of Proteins and Peptides aims to ensure successful results in the further study of this vital field.

Bio-nanoimaging

Vladimir Uversky,Yuri Lyubchenko
Bio nanoimaging Book PDF

Author : Vladimir Uversky,Yuri Lyubchenko
Publisher : Academic Press
Page : 552 pages
File Size : 53,7 Mb
Release : 2013-11-05
Category : Technology & Engineering
ISBN : 9780123978219

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Bio-nanoimaging by Vladimir Uversky,Yuri Lyubchenko Pdf

Bio-Nanoimaging: Protein Misfolding & Aggregation provides a unique introduction to both novel and established nanoimaging techniques for visualization and characterization of misfolded and aggregated protein species. The book is divided into three sections covering: - Nanotechnology and nanoimaging technology, including cryoelectron microscopy of beta(2)-microglobulin, studying amyloidogensis by FRET; and scanning tunneling microscopy of protein deposits - Polymorphisms of protein misfolded and aggregated species, including fibrillar polymorphism, amyloid-like protofibrils, and insulin oligomers - Polymorphisms of misfolding and aggregation processes, including multiple pathways of lysozyme aggregation, misfolded intermediate of a PDZ domain, and micelle formation by human islet amyloid polypeptide Protein misfolding and aggregation is a fast-growing frontier in molecular medicine and protein chemistry. Related disorders include cataracts, arthritis, cystic fibrosis, late-onset diabetes mellitus, and numerous neurodegenerative diseases like Alzheimer's and Parkinson's. Nanoimaging technology has proved crucial in understanding protein-misfolding pathologies and in potential drug design aimed at the inhibition or reversal of protein aggregation. Using these technologies, researchers can monitor the aggregation process, visualize protein aggregates and analyze their properties. Provides practical examples of nanoimaging research from leading molecular biology, cell biology, protein chemistry, biotechnology, genetics, and pharmaceutical labs Includes over 200 color images to illustrate the power of various nanoimaging technologies Focuses on nanoimaging techniques applied to protein misfolding and aggregation in molecular medicine

Zeolites and Catalysis

Jiri Cejka,Avelino Corma,Stacey Zones
Zeolites and Catalysis Book PDF

Author : Jiri Cejka,Avelino Corma,Stacey Zones
Publisher : John Wiley & Sons
Page : 918 pages
File Size : 48,8 Mb
Release : 2010-05-27
Category : Technology & Engineering
ISBN : 3527630309

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Zeolites and Catalysis by Jiri Cejka,Avelino Corma,Stacey Zones Pdf

This indispensable two-volume handbook covers everything on this hot research field. The first part deals with the synthesis, modification, characterization and application of catalytic active zeolites, while the second focuses on such reaction types as cracking, hydrocracking, isomerization, reforming and other industrially important topics. Edited by a highly experienced and internationally renowned team with chapters written by the "Who's Who" of zeolite research.