Redox Proteomics

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Redox Proteomics

Isabella Dalle-Donne,Andrea Scaloni,D. Allan Butterfield
Redox Proteomics Book PDF

Author : Isabella Dalle-Donne,Andrea Scaloni,D. Allan Butterfield
Publisher : John Wiley & Sons
Page : 978 pages
File Size : 41,7 Mb
Release : 2006-08-11
Category : Science
ISBN : 9780471973119

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Redox Proteomics by Isabella Dalle-Donne,Andrea Scaloni,D. Allan Butterfield Pdf

Methodology and applications of redox proteomics The relatively new and rapidly changing field of redox proteomics has the potential to revolutionize how we diagnose disease, assess risks, determine prognoses, and target therapeutic strategies for people with inflammatory and aging-associated diseases. This collection brings together, in one comprehensive volume, a broad array of information and insights into normal and altered physiology, molecular mechanisms of disease states, and new applications of the rapidly evolving techniques of proteomics. Written by some of the finest investigators in this area, Redox Proteomics: From Protein Modifications to Cellular Dysfunction and Diseases examines the key topics of redox proteomics and redox control of cellular function, including: * The role of oxidized proteins in various disorders * Pioneering studies on the development of redox proteomics * Analytical methodologies for identification and structural characterization of proteins affected by oxidative/nitrosative modifications * The response and regulation of protein oxidation in different cell types * The pathological implications of protein oxidation for conditions, including asthma, cardiovascular disease, diabetes, preeclampsia, and Alzheimer's disease Distinguished by its in-depth discussions, balanced methodological approach, and emphasis on medical applications and diagnosis development, Redox Proteomics is a rich resource for all professionals with an interest in proteomics, cellular physiology and its alterations in disease states, and related fields.

REDOX PROTEOMICS & BIOINFORMATICS

H. Fai Poon
REDOX PROTEOMICS BIOINFORMATICS Book PDF

Author : H. Fai Poon
Publisher : Hung Fai Poon
Page : 579 pages
File Size : 51,9 Mb
Release : 2009
Category : Electronic
ISBN : 9783838303864

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REDOX PROTEOMICS & BIOINFORMATICS by H. Fai Poon Pdf

The studies in this book demonstrated that increased oxidative stress in brain play a significant role in age-related cognitive impairment. Moreover, such increased oxidative stress leads to specific protein oxidation in the brain of cognitive impaired subject, thereby leading to cognitive function impairment. Moreover, the functional alterations of the proteins identified by proteomics in this book may leads to impaired metabolism, decline antioxidant system, and damaged synaptic communication. Ultimately, impairment of these processes lead to neuronal damages and cognitive decline. This book also show that several of the up- regulated and oxidized proteins in the brains of normal aging mice identified are known to be oxidized in neurodegenerative diseases as well, suggesting that the expression levels of certain proteins may increase as a compensatory response to oxidative stress. This compensation would allow for the maintenance of proper molecular functions in normal aging brains and protection against neurodegeneration.

Multiple Stressors: A Challenge for the Future

Carmel Mothersill,Irma Mosse,Colin Seymour
Multiple Stressors A Challenge for the Future Book PDF

Author : Carmel Mothersill,Irma Mosse,Colin Seymour
Publisher : Springer Science & Business Media
Page : 483 pages
File Size : 42,5 Mb
Release : 2007-08-20
Category : Science
ISBN : 9781402063336

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Multiple Stressors: A Challenge for the Future by Carmel Mothersill,Irma Mosse,Colin Seymour Pdf

Ecotoxiclogical risk from multiple stressors covers any situation where org- isms are exposed to a combination of environmental stressors. These include physical and chemical pollutants as well as other stressors such as parasites and environmental impact (e. g. , climate change or habitat loss). The combi- tion of stressors can result in increased risk to organisms (either additive or synergistic effects) or decreased effects (protective or antagonistic effects). The multiple stressor challenge is an international, multi-disciplinary problem requiring an international, multi-disciplinary approach. The c- rent approach to multiple stressors is to examine one stressor at a time and assume additivity. Little work has been done on combinations of stressors such that potential interactions can be determined. The problem is very complex. Multiple stressors pose a whole spectrum of challenges that range from basic science to regulation, policy and gove- ance. The challenges raise fundamental questions about our understanding of the basic biological response to stressors, as well as the implications of those uncertainties in environmental risk assessment and management. In addition to the great breadth, there is also great depth in the research ch- lenges, largely due to the complexity of the issues. From a basic science point of view, many of the mechanisms and processes under investigation are at the cutting edge of science — involving new paradigms such as genomic ins- bility and bystander effects.

Integrative Proteomics

Hon-Chiu Leung,Tsz Kwong Man,Ricardo Flores
Integrative Proteomics Book PDF

Author : Hon-Chiu Leung,Tsz Kwong Man,Ricardo Flores
Publisher : BoD – Books on Demand
Page : 456 pages
File Size : 44,7 Mb
Release : 2012-02-24
Category : Science
ISBN : 9789535100706

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Integrative Proteomics by Hon-Chiu Leung,Tsz Kwong Man,Ricardo Flores Pdf

Proteomics was thought to be a natural extension after the field of genomics has deposited significant amount of data. However, simply taking a straight verbatim approach to catalog all proteins in all tissues of different organisms is not viable. Researchers may need to focus on the perspectives of proteomics that are essential to the functional outcome of the cells. In Integrative Proteomics, expert researchers contribute both historical perspectives, new developments in sample preparation, gel-based and non-gel-based protein separation and identification using mass spectrometry. Substantial chapters are describing studies of the sub-proteomes such as phosphoproteome or glycoproteomes which are directly related to functional outcomes of the cells. Structural proteomics related to pharmaceutics development is also a perspective of the essence. Bioinformatics tools that can mine proteomics data and lead to pathway analyses become an integral part of proteomics. Integrative proteomics covers both look-backs and look-outs of proteomics. It is an ideal reference for students, new researchers, and experienced scientists who want to get an overview or insights into new development of the proteomics field.

Sub-cellular Proteomics

Harvey Millar,Nicolas L Taylor
Sub cellular Proteomics Book PDF

Author : Harvey Millar,Nicolas L Taylor
Publisher : Frontiers E-books
Page : 255 pages
File Size : 53,9 Mb
Release : 2015-01-05
Category : Botany
ISBN : 9782889193028

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Sub-cellular Proteomics by Harvey Millar,Nicolas L Taylor Pdf

Whilst significant advances have been made in whole organismal proteomics approaches, many researchers still rely on combinations of tissue selection and subcellular prefractionation methods to reduce the complexity of protein extracts from plants prior to proteomic analysis. Often this will allow identification of many lower abundance proteins of the target proteome and it may involve the selection of specific organs, cell types or the isolation of specific subcellular components. These subcellular proteomes provide insight into functions following various treatments and also contribute to the wider understanding of the entire organismal proteome by cataloguing a series of sub-proteome contents. The aim of this Research Topic is to bring together knowledge of sub cellular components in different plant species to provide a basis for accelerated research. It aims to provide a mini-review for each proposed section that summarizes the current understanding of a particular proteome, with the anticipation that every 5 - 10 years we can update these definitive publications.

Oxidative Stress and Redox Regulation

Ursula Jakob,Dana Reichmann
Oxidative Stress and Redox Regulation Book PDF

Author : Ursula Jakob,Dana Reichmann
Publisher : Springer Science & Business Media
Page : 488 pages
File Size : 44,6 Mb
Release : 2013-03-15
Category : Science
ISBN : 9789400757875

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Oxidative Stress and Redox Regulation by Ursula Jakob,Dana Reichmann Pdf

Many physiological conditions such as host defense or aging and pathological conditions such as neurodegenerative diseases, and diabetes are associated with the accumulation of high levels of reactive oxygen species and reactive nitrogen species. This generates a condition called oxidative stress. Low levels of reactive oxygen species, however, which are continuously produced during aerobic metabolism, function as important signaling molecules, setting the metabolic pace of cells and regulating processes ranging from gene expression to apoptosis. For this book we would like to recruit the experts in the field of redox chemistry, bioinformatics and proteomics, redox signaling and oxidative stress biology to discuss how organisms achieve the appropriate redox balance, the mechanisms that lead to oxidative stress conditions and the physiological consequences that contribute to aging and disease.

Thiol Redox Transitions in Cell Signaling, Part A

Anonim
Thiol Redox Transitions in Cell Signaling Part A Book PDF

Author : Anonim
Publisher : Academic Press
Page : 416 pages
File Size : 42,8 Mb
Release : 2010-07-22
Category : Science
ISBN : 0123813468

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Thiol Redox Transitions in Cell Signaling, Part A by Anonim Pdf

Thiol Redox Transitions in Cell Signaling, Part A, along with its companion (volume 475), presents methods and protocols dealing with thiol oxidation-reduction reactions and their implications as they relate to cell signaling. This first installment of Cadenas and Packer's two-volume treatment specifically deals with glutathionylation and dethiolation, and peroxide removal by peroxiredoxins/thioredoxins and glutathione peroxidases. The critically acclaimed laboratory standard for 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Over 450 volumes have been published to date, and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences. Along with companion volume, provides a full overview of techniques necessary to the study of thiol redox in relation to cell signaling Gathers tried and tested techniques from global labs, offering both new and tried-and-true methods Relevant background and reference information given for procedures can be used as a guide to developing protocols in a number of disciplines

Plant Proteomic Research 3.0

Setsuko Komatsu,Jesus V. Jorrin-Novo
Plant Proteomic Research 3 0 Book PDF

Author : Setsuko Komatsu,Jesus V. Jorrin-Novo
Publisher : MDPI
Page : 538 pages
File Size : 49,6 Mb
Release : 2021-04-29
Category : Science
ISBN : 9783036506043

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Plant Proteomic Research 3.0 by Setsuko Komatsu,Jesus V. Jorrin-Novo Pdf

The Special Issue “Plant Proteomics 3.0” was conceived in an attempt to address the recent advancements in as well as limitations of current proteomic techniques and their diverse applications to attain new insights into plant molecular responses to various biotic and abiotic stressors and the molecular bases of other processes. Proteomics’ focus is also related to translational purposes, including food traceability and allergen detection. In addition, bioinformatic techniques are needed for more confident identification, quantitation, data analysis and networking, especially with non-model or orphan plants, including medicinal and meditational plants as well as forest tree species. This Special Issue contains 23 articles, including four reviews and 19 original papers.

Proteomics in Food Science

Michelle Lisa Colgrave
Proteomics in Food Science Book PDF

Author : Michelle Lisa Colgrave
Publisher : Academic Press
Page : 538 pages
File Size : 43,9 Mb
Release : 2017-04-03
Category : Technology & Engineering
ISBN : 9780128040577

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Proteomics in Food Science by Michelle Lisa Colgrave Pdf

Proteomics in Food Science: From Farm to Fork is a solid reference providing concepts and practical applications of proteomics for those in various disciplines of food science. The book covers a range of methods for elucidating the identity or composition of specific proteins in foods or cells related to food science, from spoilage organisms, to edible components. A variety of analytical platforms are described, ranging from the usage of simple electrophoresis, to more sophisticated mass spectrometry and bio-informatic platforms. The book is designed for food scientists, technologists, food industry workers, microbiologists, and public health workers, and can also be a valuable reference book for students. Includes a variety of analytical platforms, ranging from simple electrophoresis to more sophisticated mass spectrometry and bio-informatic platforms Presents analytical techniques for each food domain, including beverages, meats, dairy and eggs, fruit, fish/seafood, cereals, nuts, and grains that range from sample collection, proportion, and storage analysis Provides applications of proteomics in hot topics area of food safety, including food spoilage, pathogenic organisms, and allergens Covers major pathogens of concern e.g., Salmonella and applications to animal husbandry

Oxidative Eustress in Exercise Physiology

James N. Cobley,Gareth W. Davison
Oxidative Eustress in Exercise Physiology Book PDF

Author : James N. Cobley,Gareth W. Davison
Publisher : CRC Press
Page : 242 pages
File Size : 51,5 Mb
Release : 2022-06-20
Category : Science
ISBN : 9781000557329

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Oxidative Eustress in Exercise Physiology by James N. Cobley,Gareth W. Davison Pdf

Oxidative Eustress in Exercise Physiology unravels key physiological responses and adaptations to different redox-regulated exercise paradigms at the cell, tissue, and whole-body level in model systems and humans in health and disease. While the mechanistic details are still unclear, key intracellular redox indices seem to be dysregulated with age. Consequently, beneficial molecular responses to acute endurance exercise decline in older individuals. Recent research suggests that manipulating mitochondrial redox homeostasis by supplementing with the mitochondria-targeted coenzyme Q10 for six weeks markedly improves physical function in older adults; i.e. it may be possible to maximise the benefits of exercise by manipulating the redox environment. The research described in this book suggests that significant translational potential exists with respect to cardiovascular disease, neurodegeneration and cancer. An international team of researchers documents the importance of redox biology in health and disease, especially when exercise is a clinically useful tool for the treatment of many diseases and conditions. Features Defines essential redox biology reactions and concepts in exercise physiology Assesses key redox parameters in an in vivo human exercise context Identifies the challenges, opportunities and boundaries of current knowledge Includes a critique of the underlying mechanisms Summarises examples of translationally important research relating to disease states Related Titles Draper, N. & H. Marshall. Exercise Physiology for Health and Sports Performance (ISBN 978-0-2737-7872-1) Wackerhage, H., ed. Molecular Exercise Physiology: An Introduction (ISBN 978-0-4156-0788-9)

Computational Systems Biology in Medicine and Biotechnology

Sonia Cortassa,Miguel A. Aon
Computational Systems Biology in Medicine and Biotechnology Book PDF

Author : Sonia Cortassa,Miguel A. Aon
Publisher : Springer Nature
Page : 494 pages
File Size : 47,8 Mb
Release : 2022-05-23
Category : Science
ISBN : 9781071618318

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Computational Systems Biology in Medicine and Biotechnology by Sonia Cortassa,Miguel A. Aon Pdf

This volume addresses the latest state-of-the-art systems biology-oriented approaches that--driven by big data and bioinformatics--are utilized by Computational Systems Biology, an interdisciplinary field that bridges experimental tools with computational tools to tackle complex questions at the frontiers of knowledge in medicine and biotechnology. The chapters in this book are organized into six parts: systems biology of the genome, epigenome, and redox proteome; metabolic networks; aging and longevity; systems biology of diseases; spatiotemporal patterns of rhythms, morphogenesis, and complex dynamics; and genome scale metabolic modeling in biotechnology. In every chapter, readers will find varied methodological approaches applied at different levels, from molecular, cellular, organ to organisms, genome to phenome, and health and disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics; criteria utilized for applying specific methodologies; lists of the necessary materials, reagents, software, databases, algorithms, mathematical models, and dedicated analytical procedures; step-by-step, readily reproducible laboratory, bioinformatics, and computational protocols all delivered in didactic and clear style and abundantly illustrated with express case studies and tutorials; and tips on troubleshooting and advice for achieving reproducibility while avoiding mistakes and misinterpretations. The overarching goal driving this volume is to excite the expert and stimulate the newcomer to the field of Computational Systems Biology. Cutting-edge and authoritative, Computational Systems Biology in Medicine and Biotechnology: Methods and Protocols is a valuable resource for pre- and post-graduate students in medicine and biotechnology, and in diverse areas ranging from microbiology to cellular and organismal biology, as well as computational and experimental biologists, and researchers interested in utilizing comprehensive systems biology oriented methods.

Environmental Problems in Marine Biology

Tamara Garcia Barrera,Jose Luis Gomez Ariza
Environmental Problems in Marine Biology Book PDF

Author : Tamara Garcia Barrera,Jose Luis Gomez Ariza
Publisher : CRC Press
Page : 524 pages
File Size : 49,8 Mb
Release : 2017-07-12
Category : Science
ISBN : 9781351645409

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Environmental Problems in Marine Biology by Tamara Garcia Barrera,Jose Luis Gomez Ariza Pdf

Marine environment can be affected by several pollutants such as the presence of elements and their chemical species, pharmaceuticals, nanoparticles and other emerging contaminants. Environmental monitoring can be assessed by genomics, proteomics (i.e. redox proteomics), chemical speciation analysis and metallomics, metabolomics as well as other advanced strategies. The present book is a useful methodological tool for researchers and specialists in the field of analytical chemistry, environmental sciences, biochemistry, genomics and toxicology. The book includes for the first time the methodological aspects and applications related to chemical speciation and –omics strategies applied to marine environment.

Proteomics of Peroxisomes

Luis A. del Río,Michael Schrader
Proteomics of Peroxisomes Book PDF

Author : Luis A. del Río,Michael Schrader
Publisher : Springer
Page : 493 pages
File Size : 40,7 Mb
Release : 2018-10-30
Category : Science
ISBN : 9789811322334

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Proteomics of Peroxisomes by Luis A. del Río,Michael Schrader Pdf

This new edited volume in the Springer Subcellular Biochemistry Series presents a comprehensive, state-of-the-art overview of the proteomics of peroxisomes derived from mammalian, Drosophila, fungal, and plant origin, and contains contributions from leading experts in the field. The development of sensitive proteomics and mass spectrometry technologies, combined with bioinformatics approaches now allow the identification of low-abundance and transient peroxisomal proteins and permits to identify the complete proteome of peroxisomes, with the consequent increase of our knowledge of the metabolic and regulatory networks of these important cellular organelles. The book lines-up with these developments and is organized in four sections including: (i) mass spectrometry-based organelle proteomics; (ii) prediction of peroxisomal proteomes; (iii) analysis of peroxisome proteome interaction networks; and (iv) peroxisomes in relation to other subcellular compartments. The editor Luis A. del Río is Professor ad honorem of the Spanish National Research Council (CSIC) in the Group of Antioxidants, Free Radicals and Nitric Oxide in Biotechnology, Food and Agriculture, Department of Biochemistry and Cell & Molecular Biology of Plants, at the Estación Experimental del Zaidín, Granada, Spain. Del Río’s research group focuses on the metabolism of reactive oxygen species (ROS), reactive nitrogen species (RNS) and antioxidants in plant peroxisomes, and the ROS- and RNS-dependent role of peroxisomes in plant cell signalling. The editor Michael Schrader is Professor of Cell Biology & Cytopathology in the Department of Biosciences at the University of Exeter, UK. Using mammalian peroxisomes as model organelles, Prof. Schrader and his team aim to unravel the molecular machinery and signalling pathways that mediate and regulate the formation, dynamics and abundance of these medically relevant cellular compartments.

Neuroproteomics

Oscar Alzate
Neuroproteomics Book PDF

Author : Oscar Alzate
Publisher : CRC Press
Page : 356 pages
File Size : 54,6 Mb
Release : 2009-10-26
Category : Medical
ISBN : 9781420076264

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Neuroproteomics by Oscar Alzate Pdf

In this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we beg

Plant Proteomics

Jozef Samaj,Jay J. Thelen
Plant Proteomics Book PDF

Author : Jozef Samaj,Jay J. Thelen
Publisher : Springer Science & Business Media
Page : 397 pages
File Size : 46,5 Mb
Release : 2007-09-09
Category : Science
ISBN : 9783540726173

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Plant Proteomics by Jozef Samaj,Jay J. Thelen Pdf

Plant Proteomics highlights rapid progress in this field, with emphasis on recent work in model plant species, sub-cellular organelles, and specific aspects of the plant life cycle such as signaling, reproduction and stress physiology. Several chapters present a detailed look at diverse integrated approaches, including advanced proteomic techniques combined with functional genomics, bioinformatics, metabolomics and molecular cell biology, making this book a valuable resource for a broad spectrum of readers.