Tubulin And Microtubules As Drug Targets For Potential Cancer Chemotherapy And Cns Directed Therapies

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Tubulin and Microtubules as Drug Targets for Potential Cancer Chemotherapy and CNS-Directed Therapies

Ludovica Monti
Tubulin and Microtubules as Drug Targets for Potential Cancer Chemotherapy and CNS Directed Therapies Book PDF

Author : Ludovica Monti
Publisher : Sapienza Università Editrice
Page : 354 pages
File Size : 47,6 Mb
Release : 2022-11-30
Category : Medical
ISBN : 9788893772426

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Tubulin and Microtubules as Drug Targets for Potential Cancer Chemotherapy and CNS-Directed Therapies by Ludovica Monti Pdf

Microtubules are essential cellular constituents of eukaryotes formed by tubulin subunits. This book is a collection of medicinal chemistry research projects that utilizes microtubules as drug targets for human diseases of global health impact. The main chapters (2 – 4) include an in-depth description of different synthetic and biological approaches to characterize the therapeutic potential of novel synthetic molecules for cancer, Alzheimer’s disease, and neglected tropical diseases. This book also includes three short chapters (5 – 7) of additional collaborative projects focused on varied drug discovery topics, including SAR studies of new lead compounds targeting carbonic anhydrase enzymes, FAAH and TRPV1, and novel bioisosteres of the carboxylic acid functional group.

Multi-drug resistant Klebsiella pneumoniae strains circulating in hospital setting

Eleonora Cella
Multi drug resistant Klebsiella pneumoniae strains circulating in hospital setting Book PDF

Author : Eleonora Cella
Publisher : Sapienza Università Editrice
Page : 160 pages
File Size : 53,6 Mb
Release : 2022-11-30
Category : Medical
ISBN : 9788893772440

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Multi-drug resistant Klebsiella pneumoniae strains circulating in hospital setting by Eleonora Cella Pdf

Carbapenems resistant Enterobacteriaceae infections are increasing worldwide representing an emerging public health problem. The application of phylogenetic and phylodynamic analyses to bacterial whole genome sequencing (WGS) data have become essential in epidemiological surveillance of MDR pathogens to discern outbreak from non-outbreak strains in both community and hospital settings. In this study, K. pneumoniae strains circulating within different wards of university hospital were collected and WGS applied. Moreover a microbiological surveillance on duedonoscopes was performed to evaluate their reprocessing. The aim was to infer the origin and the spread of K. pneumoniae nosocomial strains and to clarify the epidemiological transmission as so as the eventual reservoir in the hospital setting supporting the epidemiological surveillance and infections control strategies. Winner of the Competition “Prize for PhD Thesis 2020” arranged by Sapienza University Press.

Agave negatively regulates YAP and TAZ transcriptionally and post-translationally in osteosarcoma cell lines

Maria Ferraiuolo
Agave negatively regulates YAP and TAZ transcriptionally and post translationally in osteosarcoma cell lines Book PDF

Author : Maria Ferraiuolo
Publisher : Sapienza Università Editrice
Page : 102 pages
File Size : 40,9 Mb
Release : 2022-11-30
Category : Medical
ISBN : 9788893772457

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Agave negatively regulates YAP and TAZ transcriptionally and post-translationally in osteosarcoma cell lines by Maria Ferraiuolo Pdf

Osteosarcoma (OS) is the most aggressive type of primary solid tumor that develops in bone. Whilst conventional chemotherapy can improve survival rates, the outcome for patients with metastatic or recurrent OS remains poor, so novel treatment agents and strategies are required. Previously published works indicate that Agave exhibits anticancer properties. In the present study, anticancer effects of Agave leaf extract were investigated in the OS cells, discovering that Agave inhibits cell growth and cell migration, and sensitizes OS cells to cisplatin (CDDP), to overcome chemoresistance. Agave’s mechanisms of action include an initial process in which Agave induces YAP/TAZ oncogenic protein degradation, followed by a secondary event whereby Agave inhibits YAP/TAZ transcription through NF-κB p65:p50 heterodimers deregulation. Winner of the Competition “Prize for PhD Thesis 2020” arranged by Sapienza University Press.

Simulations of RF Beam Manipulations Including Intensity Effects for CERN PSB and SPS Upgrades

Danilo Quartullo
Simulations of RF Beam Manipulations Including Intensity Effects for CERN PSB and SPS Upgrades Book PDF

Author : Danilo Quartullo
Publisher : Sapienza Università Editrice
Page : 220 pages
File Size : 42,5 Mb
Release : 2022-11-30
Category : Science
ISBN : 9788893772433

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Simulations of RF Beam Manipulations Including Intensity Effects for CERN PSB and SPS Upgrades by Danilo Quartullo Pdf

The LIU program at CERN is of paramount importance at international level. The program foresees a significant upgrade of the LHC injector chain to increase the luminosity of the LHC beam by a factor of ten after 2024, when the HL-LHC era will start. This thesis deals with longitudinal beam dynamics studies for two LHC injectors (PSB and SPS), the main goal being the analysis of beam instabilities in the HL-LHC scenario.

Towards Recognizing New Semantic Concepts in New Visual Domains

Massimiliano Mancini
Towards Recognizing New Semantic Concepts in New Visual Domains Book PDF

Author : Massimiliano Mancini
Publisher : Sapienza Università Editrice
Page : 285 pages
File Size : 46,8 Mb
Release : 2022-11-30
Category : Computers
ISBN : 9788893772488

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Towards Recognizing New Semantic Concepts in New Visual Domains by Massimiliano Mancini Pdf

Despite being the leading paradigm in computer vision, deep neural networks are inherently limited by the visual and semantic information contained in their training set. In this thesis, we aim to design deep models operating with previously unseen visual domains and semantic concepts. We first describe different solutions for generalizing to new visual domains, applying variants of normalization layers to multiple challenging settings e.g. where new domain data is not available but arrives online or is described by metadata. In the second part, we incorporate new semantic concepts into pretrained deep models. We propose specific solutions for different problems such as multi-task/incremental learning and open-world recognition. Finally, we merge the two challenges: given images of multiple domains and categories, can we recognize unseen concepts in unseen domains? We propose an approach that is the first, promising step, towards solving this problem. Winner of the Competition “Prize for PhD Thesis 2020” arranged by Sapienza University Press.

Microtubules, in vitro

John J. Correia,Leslie Wilson
Microtubules in vitro Book PDF

Author : John J. Correia,Leslie Wilson
Publisher : Academic Press
Page : 472 pages
File Size : 46,6 Mb
Release : 2013-08-20
Category : Science
ISBN : 9780124078888

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Microtubules, in vitro by John J. Correia,Leslie Wilson Pdf

There continues to be intense interest in the microtubule cytoskeleton; the assembly, structure and regulation of microtubules; and the numerous motors and accessory proteins that control cell cycle, dynamics, organization and transport. The field continues to grow and explore new aspects of these issues driven immensely by developments in optical imaging and tracking techniques. This Second Edition brings together current research and protocols in the field of microtubules in vitro and will serve as a valuable tool for cell biologists, biophysicists and pharmacologists who study the microtubule cytoskeleton, as well as for researchers in the biomedical and biotechnology communities with interest in developing drugs that target microtubules, MAPS and motors. Chapters reflect experimental procedures and new developments in the field of microtubule in vitro research Combines classical approaches and modern technologies Presents easy-to-use protocols and thorough background information, compiled by leaders in the field

Chromosomal Instability in Cancer Cells

B. Michael Ghadimi,Thomas Ried
Chromosomal Instability in Cancer Cells Book PDF

Author : B. Michael Ghadimi,Thomas Ried
Publisher : Springer
Page : 228 pages
File Size : 41,9 Mb
Release : 2015-09-16
Category : Medical
ISBN : 9783319202914

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Chromosomal Instability in Cancer Cells by B. Michael Ghadimi,Thomas Ried Pdf

This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.

Cytotoxic Payloads for AntibodyDrug Conjugates

David E Thurston,Paul J M Jackson
Cytotoxic Payloads for AntibodyDrug Conjugates Book PDF

Author : David E Thurston,Paul J M Jackson
Publisher : Royal Society of Chemistry
Page : 502 pages
File Size : 49,6 Mb
Release : 2019-07-11
Category : Medical
ISBN : 9781788018456

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Cytotoxic Payloads for AntibodyDrug Conjugates by David E Thurston,Paul J M Jackson Pdf

Antibody–drug conjugates (ADCs) represent one of the most promising and exciting areas of anticancer drug discovery. Five ADCs are now approved in the US and EU [i.e., ado-trastuzumab emtansine (KadcylaTM), brentuximab vedotin (AdcetrisTM), inotuzumab ozogamicin (BesponsaTM), gemtuzumab ozogamicin (MylotargTM) and moxetumomab pasudotox-tdfk (Lumoxiti®)] and over 70 others are in various stages of clinical development, with impressive interim results being reported for many. The technology is based on the concept of delivering a cytotoxic payload selectively to cancer cells by attaching it to an antibody targeted to antigens on the cell surfaces. This approach has several advantages including the ability to select patients as likely responders based on the presence of antigen on the surface of their cancer cells and a wider therapeutic index, given that ADC targeting enables a more efficient delivery of cytotoxic agents to cancer cells than can be achieved by conventional chemotherapy, thus minimising systemic toxicity. Although there are many examples of antibodies that have been developed for this purpose, along with numerous linker technologies used to attach the cytotoxic agent to the antibody, there is presently a relatively small number of payload molecules in clinical use. The purpose of this book is to describe the variety of payloads used to date, along with a discussion of their advantages and disadvantages and to provide information on novel payloads at the research stage that may be used clinically in the future.

Cancer Treatment

Letícia Rangel
Cancer Treatment Book PDF

Author : Letícia Rangel
Publisher : BoD – Books on Demand
Page : 632 pages
File Size : 46,7 Mb
Release : 2013-05-09
Category : Medical
ISBN : 9789535110989

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Cancer Treatment by Letícia Rangel Pdf

Cancer Treatment: Conventional and Innovative Approaches is an attempt to integrate into a book volume the various aspects of cancer treatment, compiling comprehensive reviews written by an international team of experts in the field. The volume is presented in six sections: i) Section 1: Cancer treatment: Conventional and innovative pharmacological approaches; ii) Section 2: Combinatorial strategies to fight cancer: Surgery, radiotherapy, backytherapy, chemotherapy, and hyperthermia; iii) Section 3: The immunotherapy of cancer; iv) Section 4: Multidisciplinarity in cancer therapy: nutrition and beyond; v) Section 5: Supportive care for cancer patients; vi) Section 6: Perspectives in cancer biology and modeling. Ultimately, we hope this book can enlighten important issues involved in the management of cancer, summarizing the state-of-the-art knowledge regarding the disease control and treatment; thus, providing means to improve the overall care of patients that daily battle against this potentially lethal condition.

Cancer Chemotherapy and Biotherapy

Bruce A. Chabner,Dan L. Longo
Cancer Chemotherapy and Biotherapy Book PDF

Author : Bruce A. Chabner,Dan L. Longo
Publisher : Lippincott Williams & Wilkins
Page : 836 pages
File Size : 51,7 Mb
Release : 2011-12-07
Category : Medical
ISBN : 9781451148206

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Cancer Chemotherapy and Biotherapy by Bruce A. Chabner,Dan L. Longo Pdf

Updated to include the newest drugs and those currently in development, this Fifth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents—their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations. This edition's introduction includes timely information on general strategies for drug usage, the science of drug discovery and development, economic and regulatory aspects of cancer drug development, and principles of pharmacokinetics. Eight new chapters have been added and more than twenty have been significantly revised. A companion website includes the fully searchable text and an image bank.

Tau Biology

Akihiko Takashima,Benjamin Wolozin,Luc Buee
Tau Biology Book PDF

Author : Akihiko Takashima,Benjamin Wolozin,Luc Buee
Publisher : Springer Nature
Page : 416 pages
File Size : 51,9 Mb
Release : 2020-02-24
Category : Medical
ISBN : 9789813293588

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Tau Biology by Akihiko Takashima,Benjamin Wolozin,Luc Buee Pdf

This book presents essential studies and cutting-edge research results on tau, which is attracting increasing interest as a target for the treatment of Alzheimer's disease. Tau is well known as a microtubule-associated protein that is predominantly localized in the axons of neurons. In various forms of brain disease, neuronal loss occurs, with deposition of hyperphosphorylated tau in the remaining neurons. Important questions remain regarding the way in which tau forms hyperphosphorylated and fibrillar deposits in neurons, and whether tau aggregation represents the toxic pathway leading to neuronal death. With the help of new technologies, researchers are now solving these long-standing questions. In this book, readers will find the latest expert knowledge on all aspects of tau biology, including the structure and role of the tau molecule, tau localization and function, the pathology, drivers, and markers of tauopathies, tau aggregation, and treatments targeting tau. Tau Biology will be an invaluable source of information and fresh ideas for those involved in the development of more effective therapies and for all who seek a better understanding of the biology of the aging brain.

Molecular Therapies of Cancer

Georg F. Weber
Molecular Therapies of Cancer Book PDF

Author : Georg F. Weber
Publisher : Springer
Page : 488 pages
File Size : 46,6 Mb
Release : 2015-07-22
Category : Medical
ISBN : 9783319132785

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Molecular Therapies of Cancer by Georg F. Weber Pdf

Molecular Therapies of Cancer comprehensively covers the molecular mechanisms of anti-cancer drug actions in a comparably systematic fashion. While there is currently available a great deal of literature on anti-cancer drugs, books on the subject are often concoctions of invited review articles superficially connected to one another. There is a lack of comprehensive and systematic text on the topic of molecular therapies in cancer. A further deficit in the relevant literature is a progressive sub-specialization that typically limits textbooks on cancer drugs to cover either pharmacology or medicinal chemistry or signal transduction, rather than explaining molecular drug actions across all those areas; Molecular Therapies of Cancer fills this void. The book is divided into five sections: 1. Molecular Targeting of Cancer Cells; 2. Emerging and Alternative Treatment Modalities; 3. Molecular Targeting of Tumor-Host Interactions; 4. Anti-Cancer Drug Pharmacokinetics; and 5. Supportive Therapies.

The Role of Microtubules in Cell Biology, Neurobiology, and Oncology

Antonio Tito Fojo
The Role of Microtubules in Cell Biology Neurobiology and Oncology Book PDF

Author : Antonio Tito Fojo
Publisher : Springer Science & Business Media
Page : 629 pages
File Size : 51,5 Mb
Release : 2009-01-14
Category : Medical
ISBN : 9781597453363

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The Role of Microtubules in Cell Biology, Neurobiology, and Oncology by Antonio Tito Fojo Pdf

This book presents the first comprehensive exploration of the dynamic potential of microtubules anti-cancer targets. Written by leading anti-cancer researchers, this groundbreaking volume collects the most current microtubule research available and investigates the potential of microtubules in cancer therapy.

Kinesins and Cancer

Frank Kozielski, FSB
Kinesins and Cancer Book PDF

Author : Frank Kozielski, FSB
Publisher : Springer
Page : 271 pages
File Size : 50,5 Mb
Release : 2015-03-02
Category : Medical
ISBN : 9789401797320

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Kinesins and Cancer by Frank Kozielski, FSB Pdf

This interdisciplinary volume collates research work on kinesins and cancer. Authors attempt to validate members of the kinesin superfamily as potential targets for drug development in cancer chemotherapy. The work begins by highlighting the importance of kinesins, summarising current knowledge and how they are shown to be crucial for mitosis. Chapters go on to explore how this family of proteins are emerging as a novel target for chemotherapeutic intervention and drug development. Readers will learn how kinesins travel along microtubules to fulfill their many roles in intracellular transport or cell division. Several compounds that inhibit two mitotic kinesins (called Eg5 and CENP-E) have entered Phase I and II clinical trials and are explored in these chapters. Additional mitotic kinesins are currently being validated as drug targets, raising the possibility that the repertoire of kinesin-based drug targets may expand in the future. The book is suitable as a reference standard for the field of kinesins and cancer. It will interest those in academia and pharmaceutical companies, and anyone with an interest in the medical relevance of these proteins, which cutting edge methodologies are now enabling us to understand in astonishing detail.

Metronomic Chemotherapy

Guido Bocci,Giulio Francia
Metronomic Chemotherapy Book PDF

Author : Guido Bocci,Giulio Francia
Publisher : Springer
Page : 302 pages
File Size : 51,5 Mb
Release : 2014-09-04
Category : Medical
ISBN : 9783662436042

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Metronomic Chemotherapy by Guido Bocci,Giulio Francia Pdf

This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.