Venom Genomics And Proteomics

Author : P. Gopalakrishnakone,Juan J. Calvete
Publisher : Springer
Page : 0 pages
File Size : 44,5 Mb
Release : 2015-10-14
Category : Medical
ISBN : 9400764154

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Venom Genomics and Proteomics by P. Gopalakrishnakone,Juan J. Calvete Pdf

In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, Toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, Diabetes, Chronic Pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to Toxinology. The Handbook of Toxinology aims to address this gap and cover the field of Toxinology comprehensively.

Author : Jay Fox,José María Gutiérrez
Publisher : MDPI
Page : 277 pages
File Size : 45,5 Mb
Release : 2018-07-10
Category : Electronic
ISBN : 9783038424260

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Snake Venom Metalloproteinases by Jay Fox,José María Gutiérrez Pdf

This book is a printed edition of the Special Issue "Snake Venom Metalloproteinases" that was published in Toxins

Author : P. Gopalakrishnakone,Gerardo Corzo,Elia Diego-García,Maria Elena de Lima
Publisher : Unknown
Page : 128 pages
File Size : 42,7 Mb
Release : 2024-06-26
Category : Poisonous spiders
ISBN : 9400766467

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Spider Venoms by P. Gopalakrishnakone,Gerardo Corzo,Elia Diego-García,Maria Elena de Lima Pdf

Author : Steven D. Aird
Publisher : MDPI
Page : 210 pages
File Size : 51,9 Mb
Release : 2020-12-29
Category : Science
ISBN : 9783039364671

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Identification and Functional Characterization of Novel Venom Components by Steven D. Aird Pdf

Throughout most of the 20th century, the toxinological literature consisted largely of pharmacological and functional characterizations of crude venoms and venom constituents, often constituents that could not be identified unambiguously. The advent of amino acid composition analysis in the 1950s enabled the first forays into physical characterizations of purified toxins, though these remained few in number until the 1970s. Then, the tryptic and chymotryptic cleavage of venom proteins coupled with manual Edman degradation began to provide the first complete sequences, particularly of three-finger toxins. Polyacrylamide gel electrophoresis and improved resins for liquid chromatography permitted improved purification and better gross structural characterization of venom components. The early 1980s witnessed the advent of automated Edman degradation, and entire sequences of longer proteins began to be reported in the literature. Then, the molecular biology revolution enabled the generation of cDNA sequences of more and larger proteins, followed by mass-spectrometry-based proteomics and quantitative high-throughput DNA sequencing and genomics. Today, we face an unprecedented situation in which our capacity to generate sequence/structural data has completely overwhelmed our capacity to functionally characterize venom constituents. This Special Issue of Toxins includes 11 publications addressing the discovery and functional characterization of novel venom constituents of vertebrate and invertebrate venoms.

Author : P. Gopalakrishnakone,Anita Malhotra
Publisher : Unknown
Page : 128 pages
File Size : 46,6 Mb
Release : 2015
Category : Electronic books
ISBN : 9400767277

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Evolution of Venomous Animals and Their Toxins by P. Gopalakrishnakone,Anita Malhotra Pdf

Author : Sebastien Dutertre,Maria Vittoria Modica,Mande Holford,Kartik Sunagar
Publisher : Frontiers Media SA
Page : 127 pages
File Size : 41,8 Mb
Release : 2020-05-06
Category : Electronic
ISBN : 9782889637126

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Diversity and Evolution of Animal Venoms: Neglected Targets, Ecological Interactions, Future Perspectives by Sebastien Dutertre,Maria Vittoria Modica,Mande Holford,Kartik Sunagar Pdf

Author : P. Gopalakrishnakone,Hidetoshi Inagaki,Ashis K. Mukherjee,Tarek R. Rahmy,Carl-Wilhelm Vogel
Publisher : Unknown
Page : 128 pages
File Size : 55,7 Mb
Release : 2015
Category : Poisonous snakes
ISBN : 9400766483

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Snake Venoms by P. Gopalakrishnakone,Hidetoshi Inagaki,Ashis K. Mukherjee,Tarek R. Rahmy,Carl-Wilhelm Vogel Pdf

Author : Stephen P. Mackessy
Publisher : CRC Press
Page : 681 pages
File Size : 43,9 Mb
Release : 2021-05-24
Category : Nature
ISBN : 9780429623622

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Handbook of Venoms and Toxins of Reptiles by Stephen P. Mackessy Pdf

A decade after publication of the first edition, Handbook of Venoms and Toxins of Reptiles responds to extensive changes in the field of toxinology to endure as the most comprehensive review of reptile venoms on the market. The six sections of this new edition, which has nearly doubled in size, complement the original handbook by presenting current information from many of the leading researchers and physicians in toxinology, with topics ranging from functional morphology, evolution and ecology to crystallography, -omics technologies, drug discovery and more. With the recent recognition by the World Health Organization of snakebite as a neglected tropical disease, the section on snakebite has been expanded and includes several chapters dealing with the problem broadly and with new technologies and the promises these new approaches may hold to counter the deleterious effects of envenomation. This greatly expanded handbook offers a unique resource for biologists, biochemists, toxicologists, physicians, clinicians, and epidemiologists, as well as informed laypersons interested in the biology of venomous reptiles, the biochemistry and molecular biology of venoms, and the effects and treatment of human envenomation.

Author : Glenn F. King
Publisher : Royal Society of Chemistry
Page : 320 pages
File Size : 42,9 Mb
Release : 2015-01-27
Category : Science
ISBN : 9781782624370

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Venoms to Drugs by Glenn F. King Pdf

The pharmaceutical industry has become increasingly interested in biologics from animal venoms as a potential source for therapeutic agents in recent years, with a particularly emphasis on peptides. To date six drugs derived from venom peptides or proteins have been approved by the FDA, with nine further agents currently being investigated in clinical trials. In addition to these drugs in approved or advanced stages of development, many more peptides and proteins are being studied in varying stages of preclinical development. This unique book provides an up to date and comprehensive account of the potential of peptides and proteins from animal venoms as possible therapeutics. Topics covered include chemistry and structural biology of animal venoms, proteomic and transcriptomic approaches to drug discovery, bioassays, high-throughput screens and target identification, and reptile, scorpion, spider and cone snail venoms as a platform for drug development. Case studies are used to illustrate methods and successes and highlight issues surrounding administration and other important lessons that have been learnt from the development of approved therapeutics based on venoms. The first text to focus on this fascinating area and bridging an important gap, this book provides the reader with essential and current knowledge on this fast-developing area. Venoms to Drugs will find wide readership with researchers working in academia and industry working in all medicinal and pharmaceutical areas.

Author : Michael Schrader
Publisher : Springer Nature
Page : 503 pages
File Size : 47,8 Mb
Release : 2024-06-26
Category : Electronic
ISBN : 9781071636466

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Peptidomics by Michael Schrader Pdf

Author : P. Gopalakrishnakone,Elisabeth F. Schwartz,Lourival D. Possani,Ricardo C. Rodríguez de la Vega
Publisher : Springer
Page : 550 pages
File Size : 40,5 Mb
Release : 2021-01-14
Category : Medical
ISBN : 9400766475

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Scorpion Venoms by P. Gopalakrishnakone,Elisabeth F. Schwartz,Lourival D. Possani,Ricardo C. Rodríguez de la Vega Pdf

In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, Toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, Diabetes, Chronic Pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to Toxinology. The Handbook of Toxinology aims to address this gap and cover the field of Toxinology comprehensively.

Author : P. Gopalakrishnakone,Lourdes J. Cruz,Sulan Luo
Publisher : Springer
Page : 0 pages
File Size : 45,5 Mb
Release : 2019-09-11
Category : Medical
ISBN : 9400764510

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Toxins and Drug Discovery by P. Gopalakrishnakone,Lourdes J. Cruz,Sulan Luo Pdf

In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, Toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, Diabetes, Chronic Pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to Toxinology. The Handbook of Toxinology aims to address this gap and cover the field of Toxinology comprehensively.

Author : David J. Gower,Hussam Zaher
Publisher : Cambridge University Press
Page : 489 pages
File Size : 41,8 Mb
Release : 2022-08-11
Category : Science
ISBN : 9781108945073

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The Origin and Early Evolutionary History of Snakes by David J. Gower,Hussam Zaher Pdf

Snakes comprise nearly 4,000 extant species found on all major continents except Antarctica. Morphologically and ecologically diverse, they include burrowing, arboreal, and marine forms, feeding on prey ranging from insects to large mammals. Snakes are strikingly different from their closest lizard relatives, and their origins and early diversification have long challenged and enthused evolutionary biologists. The origin and early evolution of snakes is a broad, interdisciplinary topic for which experts in palaeontology, ecology, physiology, embryology, phylogenetics, and molecular biology have made important contributions. The last 25 years has seen a surge of interest, resulting partly from new fossil material, but also from new techniques in molecular and systematic biology. This volume summarises and discusses the state of our knowledge, approaches, data, and ongoing debates. It provides reviews, syntheses, new data and perspectives on a wide range of topics relevant to students and researchers in evolutionary biology, neontology, and palaeontology.

Author : P. Gopalakrishnakone,Gerardo A. Corzo,Elia Diego-Garcia,Maria Elena Lima
Publisher : Springer
Page : 0 pages
File Size : 47,7 Mb
Release : 2016-05-10
Category : Medical
ISBN : 9400763883

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Spider Venoms by P. Gopalakrishnakone,Gerardo A. Corzo,Elia Diego-Garcia,Maria Elena Lima Pdf

In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, Toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, Diabetes, Chronic Pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to Toxinology. The Handbook of Toxinology aims to address this gap and cover the field of Toxinology comprehensively.

Author : Stephen P. Mackessy
Publisher : CRC Press
Page : 912 pages
File Size : 45,5 Mb
Release : 2021-05-24
Category : Nature
ISBN : 9780429623455

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Handbook of Venoms and Toxins of Reptiles by Stephen P. Mackessy Pdf

A decade after publication of the first edition, Handbook of Venoms and Toxins of Reptiles responds to extensive changes in the field of toxinology to endure as the most comprehensive review of reptile venoms on the market. The six sections of this new edition, which has nearly doubled in size, complement the original handbook by presenting current information from many of the leading researchers and physicians in toxinology, with topics ranging from functional morphology, evolution and ecology to crystallography, -omics technologies, drug discovery and more. With the recent recognition by the World Health Organization of snakebite as a neglected tropical disease, the section on snakebite has been expanded and includes several chapters dealing with the problem broadly and with new technologies and the promises these new approaches may hold to counter the deleterious effects of envenomation. This greatly expanded handbook offers a unique resource for biologists, biochemists, toxicologists, physicians, clinicians, and epidemiologists, as well as informed laypersons interested in the biology of venomous reptiles, the biochemistry and molecular biology of venoms, and the effects and treatment of human envenomation.