Zika Virus And Host Interactions

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Zika Virus and Host Interactions

Tom Hobman,Anil Kumar,Daniel Limonta
Zika Virus and Host Interactions Book PDF

Author : Tom Hobman,Anil Kumar,Daniel Limonta
Publisher : MDPI
Page : 256 pages
File Size : 41,8 Mb
Release : 2021-03-24
Category : Science
ISBN : 9783039439492

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Zika Virus and Host Interactions by Tom Hobman,Anil Kumar,Daniel Limonta Pdf

Zika virus (ZIKV), one of the flavivirus family members transmitted by mosquitos, was declared a Public Health Emergency of International Concern by the WHO in February 2016 because of clusters of newborn microcephaly cases and other neurological disorders in Brazil. Most ZIKV infections result in a self-limited flu-like febrile disease, however, if contracted during pregnancy, the virus can also infect fetuses and cause a spectrum of birth defects known as congenital Zika syndrome. To date, no vaccines or antiviral drugs are licensed for ZIKV, and the virus has spread and become endemic to many tropical and sub-tropical countries. Included in this book are thirteen reports addressing diverse aspects of ZIKV–host interactions. These studies range from basic science to clinical research. It is expected that findings from these studies will contribute to a better understanding of the host cells interacting with ZIKV, and may serve as the basis for new diagnostics, antiviral therapies, and vaccine design.

Zika Virus and Host Interactions

Tom Hobman,Anil Kumar,Daniel Limonta
Zika Virus and Host Interactions Book PDF

Author : Tom Hobman,Anil Kumar,Daniel Limonta
Publisher : Unknown
Page : 256 pages
File Size : 47,6 Mb
Release : 2021
Category : Electronic
ISBN : 3039439502

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Zika Virus and Host Interactions by Tom Hobman,Anil Kumar,Daniel Limonta Pdf

Zika virus (ZIKV), one of the flavivirus family members transmitted by mosquitos, was declared a Public Health Emergency of International Concern by the WHO in February 2016 because of clusters of newborn microcephaly cases and other neurological disorders in Brazil. Most ZIKV infections result in a self-limited flu-like febrile disease, however, if contracted during pregnancy, the virus can also infect fetuses and cause a spectrum of birth defects known as congenital Zika syndrome. To date, no vaccines or antiviral drugs are licensed for ZIKV, and the virus has spread and become endemic to many tropical and sub-tropical countries. Included in this book are thirteen reports addressing diverse aspects of ZIKV-host interactions. These studies range from basic science to clinical research. It is expected that findings from these studies will contribute to a better understanding of the host cells interacting with ZIKV, and may serve as the basis for new diagnostics, antiviral therapies, and vaccine design.

New Advances on Zika Virus Research

Luis Martinez-Sobrido,Fernando Almazan Toral
New Advances on Zika Virus Research Book PDF

Author : Luis Martinez-Sobrido,Fernando Almazan Toral
Publisher : MDPI
Page : 554 pages
File Size : 42,7 Mb
Release : 2019-04-02
Category : Arctic medicine. Tropical medicine
ISBN : 9783038977643

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New Advances on Zika Virus Research by Luis Martinez-Sobrido,Fernando Almazan Toral Pdf

Zika virus (ZIKV) is a mosquito-borne member of the Flaviviridae family that historically has been associated with mild febrile illness. However, the recent outbreaks in Brazil in 2015 and its rapid spread throughout South and Central America and the Caribbean, together with its association with severe neurological disorders—including fetal microcephaly and Guillain-Barré syndrome in adults—have changed the historic perspective of ZIKV. Currently, ZIKV is considered an important public health concern that has the potential to affect millions of people worldwide. The significance of ZIKV in human health and the lack of approved vaccines and/or antiviral drugs to combat ZIKV infection have triggered a global effort to develop effective countermeasures to prevent and/or treat ZIKV infection. In this Special Issue of Viruses, we have assembled a collection of 32 research and review articles that cover the more recent advances on ZIKV molecular biology, replication and transmission, virus–host interactions, pathogenesis, epidemiology, vaccine development, antivirals, and viral diagnosis.

Host-Pathogen Interactions During Arboviral Infections

Alan G. Goodman,Angela L. Rasmussen
Host Pathogen Interactions During Arboviral Infections Book PDF

Author : Alan G. Goodman,Angela L. Rasmussen
Publisher : Frontiers Media SA
Page : 125 pages
File Size : 46,7 Mb
Release : 2019-07-19
Category : Electronic
ISBN : 9782889459179

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Host-Pathogen Interactions During Arboviral Infections by Alan G. Goodman,Angela L. Rasmussen Pdf

Arboviruses, or arthropod-borne viruses, such as West Nile virus, Dengue virus, and Zika virus, pose a serious threat to public health worldwide. West Nile virus was introduced to the United States in 1999, and is now endemic, causing over 2,000 domestically acquired cases in the U.S. annually in mammals. Similarly, dengue and Zika viruses are endemic in the Americas and pose novel threats to the human population. Tick-borne viruses such as Powassan virus and Heartland virus are increasing in frequency in the U.S. At this time, there is no commercially available vaccine or therapeutic to treat these viral infections. Because nearly every mammalian case of these virus infections originates from the insect vector, it is imperative that we also understand viral pathogenesis, transmission, and the immune response in insect models as well as pathogenesis and the host responses in infected mammals. The development of methods to block arbovirus transmission from the vector may be effective at ceasing arthropod-to-human infection since the current recommendation to prevent these viral infections is to decrease contact with mosquitoes. Additionally, improving our understanding of epidemiology and ecology will also help develop measures to reduce virus spread. In order to better study mammalian and insect host responses to infection, a number of genetic tools are available, such as fly, mosquito, and tick models, recombinant viruses, mouse models, and bioinformatics tools. The studies described in this eBook will illustrate host responses to infection using mammalian and insect models, identify critical signaling nodes of the innate immune response, and discuss virus transmission from insect to mammal or among infected hosts. Taken together, these studies will elucidate means of decreasing infections in human populations and provide potential targets for future study and therapeutic design.

Zika Virus and Diseases

Suzane R. da Silva,Fan Cheng,Shou-Jiang Gao
Zika Virus and Diseases Book PDF

Author : Suzane R. da Silva,Fan Cheng,Shou-Jiang Gao
Publisher : John Wiley & Sons
Page : 276 pages
File Size : 40,7 Mb
Release : 2018-05-08
Category : Science
ISBN : 9781119408642

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Zika Virus and Diseases by Suzane R. da Silva,Fan Cheng,Shou-Jiang Gao Pdf

Compiles the most current information on the Zika virus and its associated diseases This comprehensive book provides the most up-to-date information for students, medical students, and scientists on Zika virus and its associated diseases. It includes all the information related to the Zika virus since its discovery in 1947; its epidemic outbreak in 2007-2014; how the epidemiology changed in America in 2015-2016; its mode of transmission; how to prevent and treat it; and associated diseases. Zika Virus and Diseases: From Molecular Biology to Epidemiology offers complete and up-to-date coverage in 10 chapters. It presents information from papers that attempted to associate the virus with diseases in Africa until the first animal experiment; discusses its association with Guillain-Barré syndrome and microcephaly; describes the basic mechanisms for Zika (ZIKV) replication, including important differences between Dengue (DENV), West-Nile virus (WNV), and ZIKV; explains the difference between the strains and discusses the pathogenesis of them; covers the papers that showed all the interferences that Zika can cause, and the pathways which can be modified; and more. The first book since 1947 to put together all the scientific information Compiles all the information received in the last year about Zika virus Clearly demonstrates the origin and discovery of the virus Zika Virus and Diseases: From Molecular Biology to Epidemiology will appeal to graduate students, medical students, basic researchers, clinicians in infectious disease, microbiology, and virology, as well as people in related disciplines interested in learning more about this topic.

Japanese Encephalitis and West Nile Viruses

John Mackenzie,A.D.T. Barrett,V. Deubel
Japanese Encephalitis and West Nile Viruses Book PDF

Author : John Mackenzie,A.D.T. Barrett,V. Deubel
Publisher : Springer Science & Business Media
Page : 423 pages
File Size : 49,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642594038

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Japanese Encephalitis and West Nile Viruses by John Mackenzie,A.D.T. Barrett,V. Deubel Pdf

Japanese encephalitis and West Nile viruses are members of the Japanese encephalitis serological group of the genus Flavivirus and therefore closely related genetically and antigenically. They share a number of properties, including the use of birds as their major wildlife maintenance host and Culicine mosquitoes for transmission, and they are both associated with severe human disease, as well as fatal infections in horses. The emergence of these two viruses, and their well-established propensity to colonise new areas, make it timely to re-examine their ecology, biology, molecular structure, replication and epidemiology, and these therefore provide the focus of this volume.

Virus as Populations

Esteban Domingo
Virus as Populations Book PDF

Author : Esteban Domingo
Publisher : Academic Press
Page : 426 pages
File Size : 49,7 Mb
Release : 2019-11-06
Category : Science
ISBN : 9780128163320

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Virus as Populations by Esteban Domingo Pdf

Virus as Composition, Complexity, Quasispecies, Dynamics, and Biological Implications, Second Edition, explains the fundamental concepts surrounding viruses as complex populations during replication in infected hosts. Fundamental phenomena in virus behavior, such as adaptation to changing environments, capacity to produce disease, and the probability to be transmitted or respond to treatment all depend on virus population numbers. Concepts such as quasispecies dynamics, mutations rates, viral fitness, the effect of bottleneck events, population numbers in virus transmission and disease emergence, and new antiviral strategies are included. The book's main concepts are framed by recent observations on general virus diversity derived from metagenomic studies and current views on the origin and role of viruses in the evolution of the biosphere. Features current views on key steps in the origin of life and origins of viruses Includes examples relating ancestral features of viruses with their current adaptive capacity Explains complex phenomena in an organized and coherent fashion that is easy to comprehend and enjoyable to read Considers quasispecies as a framework to understand virus adaptability and disease processes

Membrane Fusion

Jan Wilschut
Membrane Fusion Book PDF

Author : Jan Wilschut
Publisher : CRC Press
Page : 930 pages
File Size : 50,7 Mb
Release : 1990-09-28
Category : Medical
ISBN : 0824783018

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Membrane Fusion by Jan Wilschut Pdf

A broad overview of recent progress in membrane fusion research, treating the subject from the fields of biophysics, biochemistry, cell biology, virology, and biotechnology. Featuring sections on the general properties of membranes and applications of membrane fusion techniques, this sourcebook outl

Dengue and Zika: Control and Antiviral Treatment Strategies

Rolf Hilgenfeld,Subhash G. Vasudevan
Dengue and Zika Control and Antiviral Treatment Strategies Book PDF

Author : Rolf Hilgenfeld,Subhash G. Vasudevan
Publisher : Springer
Page : 375 pages
File Size : 47,8 Mb
Release : 2018-05-29
Category : Medical
ISBN : 9789811087271

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Dengue and Zika: Control and Antiviral Treatment Strategies by Rolf Hilgenfeld,Subhash G. Vasudevan Pdf

This contributed volume contains 25 chapters from leading international scientists working on dengue and Zika viruses, who came together in Praia do Tofo in Mozambique to discuss the latest developments in the fields of epidemiology, pathogenesis, structural virology, immunology, antiviral drug discovery and development, vaccine efficacy, and mosquito control programs. The meeting venue offered an opportunity to discuss current research on these flaviviruses in an idyllic setting, and also to develop first-hand appreciation of the issues in infectious diseases facing developing countries and of the research gaps in Africa. For readers, who should include basic and clinical researchers in the field and public health professionals, the chapters are organized to provide a comprehensive overview of the various topics in current dengue and Zika virus research. A unique feature of the proceedings of this meeting is the inclusion of the discussions that took place following presentations. These have been transcribed and appended to the end of the relevant chapters, and they form the “salt in the soup” of this book.

Gadd45 Stress Sensor Genes

Dan A. Liebermann,Barbara Hoffman
Gadd45 Stress Sensor Genes Book PDF

Author : Dan A. Liebermann,Barbara Hoffman
Publisher : Springer Science & Business Media
Page : 141 pages
File Size : 43,8 Mb
Release : 2013-10-08
Category : Medical
ISBN : 9781461482895

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Gadd45 Stress Sensor Genes by Dan A. Liebermann,Barbara Hoffman Pdf

Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress. The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins). These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity. Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress. Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus. Protein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors & the molecular pathways involved.

RNA Worlds

John F. Atkins,Raymond F. Gesteland,Thomas Cech,Cold Spring Harbor Laboratory. Press
RNA Worlds Book PDF

Author : John F. Atkins,Raymond F. Gesteland,Thomas Cech,Cold Spring Harbor Laboratory. Press
Publisher : Unknown
Page : 0 pages
File Size : 43,8 Mb
Release : 2011
Category : Science
ISBN : 0879699469

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RNA Worlds by John F. Atkins,Raymond F. Gesteland,Thomas Cech,Cold Spring Harbor Laboratory. Press Pdf

This volume reviews our understanding of two RNA worlds: the primordial RNA world before DNA, in which RNA was both information store and biocatalyst; and the contemporary RNA world, in which mRNA, tRNA, rRNA, siRNA, miRNA, and a host of other RNAs operate.

Proteogenomics

Ákos Végvári
Proteogenomics Book PDF

Author : Ákos Végvári
Publisher : Springer
Page : 184 pages
File Size : 41,5 Mb
Release : 2016-09-29
Category : Science
ISBN : 9783319423166

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Proteogenomics by Ákos Végvári Pdf

This book highlights key technologies and identifies areas for further development in proteogenomics. The utility and usefulness of very large Omics data sets (Next Gen Sequencing of DNA, RNA-seq, ribosome profiling, mass spectrometry- and antibody-based proteomics) is discussed and opportunities and challenges of related bioinformatics applications are outlined. The reader will be able to appreciate the interdisciplinary nature of the continuously evolving area of proteogenomics, which has already grown beyond its original concept of verifying gene annotations by proteomics. The chapters presented in this book are arranged to offer a general overview, rather than to provide detailed descriptions of technologies. The selected applications will provide useful insight into the level of detail that can be obtained in relation to certain diseases areas, including cancer biology and personalized medicine. The readers will find that each chapter delivers a comprehensive approach to proteogenomics, each from the point of view of a specific application. Research scientists interested in innovative processes that can offer a unique and at the same time a more complete access to technological developments and concepts that in turn can contribute to a better understand biological functions should read this book.

Advanced Concepts in Human Immunology: Prospects for Disease Control

Pooja Jain,Lishomwa C. Ndhlovu
Advanced Concepts in Human Immunology Prospects for Disease Control Book PDF

Author : Pooja Jain,Lishomwa C. Ndhlovu
Publisher : Springer Nature
Page : 413 pages
File Size : 50,8 Mb
Release : 2020-08-11
Category : Medical
ISBN : 9783030339463

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Advanced Concepts in Human Immunology: Prospects for Disease Control by Pooja Jain,Lishomwa C. Ndhlovu Pdf

This book highlights information derived primarily from clinical samples, with particular reference to theoretical and scientific aspects of the human immune system. This text will focus on topics that range from host-pathogen interactions in infectious disease to host immune response in cancer, allergic diseases, neuroinflammatory diseases, and autoimmune disorders. The reader will also have a well-rounded understanding of the behavior of the immune system with particular emphasis on the role of immunoproteomics in immunotherapy, neuroprotective immunity for neurodegenerative and neuroinfectious disease, leukemia-associated dendritic cell induction of adaptive immunity dysregulation, and the role of immune checkpoint inhibitors in cancer, infection, as well as neuroinflammation. Taken together, the contents of this book are intended for both clinicians and researchers in academia and industry.

Human Viruses: Diseases, Treatments and Vaccines

Shamim I. Ahmad
Human Viruses Diseases Treatments and Vaccines Book PDF

Author : Shamim I. Ahmad
Publisher : Springer Nature
Page : 745 pages
File Size : 51,5 Mb
Release : 2021-05-19
Category : Medical
ISBN : 9783030711658

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Human Viruses: Diseases, Treatments and Vaccines by Shamim I. Ahmad Pdf

This book discusses current evidence on human viruses and provides an extensive coverage of newly emerged viruses and current strategies for treatment. Offering a new perspective in view of the re-emergence of Ebola in African countries and Dengue in India and Pakistan, the contents include chapters on emergence, pathogenicity, epidemiology and vaccine uptake. Human Viruses: Diseases, Treatments and Vaccines: The New Insights discusses a range of viruses from the most common such as Influenza and Hepatitis to Zika, Poliomyelitis and Chikungunya among many others. It is authored by a team of experts on viral disease and will be of immense use to virologists, public health experts and clinicians.

Virology Methods Manual

Hillar O. Kangro,Brian W.J. Mahy
Virology Methods Manual Book PDF

Author : Hillar O. Kangro,Brian W.J. Mahy
Publisher : Elsevier
Page : 374 pages
File Size : 49,6 Mb
Release : 1996-04-16
Category : Science
ISBN : 0080543588

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Virology Methods Manual by Hillar O. Kangro,Brian W.J. Mahy Pdf

The Virology Methods Manual is a comprehensive source of methods for the study, manipulation, and detection of viruses. Edited by Brian Mahy and Hillar Kangro, this work describes the most up-to-date, definitive techniques, provided by experts in each area, and presented with easy-to-use, step-by-step protocols. This new manual will satisfy the needs of virologists and all those working with viruses who need a practical guide to methods that work! Provides up-to-date techniques by experts worldwide Presents common, step-by-step protocols in an attractive, easy-to-use fashion Contains useful appendices including virus taxonomy, metabolic inhibitors, and Bio-safety in the virology laboratory