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Author : United States. Food and Drug Administration,Inhalation Toxicology Research Institute
Publisher : Unknown
Page : 300 pages
File Size : 55,7 Mb
Release : 1979
Category : Aerosols
ISBN : UCSD:31822017133745
Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 51,7 Mb
Release : 1980
Category : Electronic
ISBN : OCLC:251340041
Author : Harry Salem,Sidney A. Katz
Publisher : CRC Press
Page : 1055 pages
File Size : 47,6 Mb
Release : 2005-12-22
Category : Medical
ISBN : 9781420037302
Written by internationally recognized scientists from academic, industrial, and governmental sectors, Inhalation Toxicology, Second Edition details the methods and materials used in the theoretical and applied aspects of inhalation toxicology. The editors emphasize the relationship between the respiratory system and toxicology of inhaled substances
Author : Ulrich Mohr,Donald L. Dungworth,Georg Kimmerle,James Lewkowski,Roger O. McClellan,Werner Stöber
Publisher : Springer Science & Business Media
Page : 320 pages
File Size : 40,9 Mb
Release : 2013-03-07
Category : Medical
ISBN : 9783642613555
The International Life Sciences Institute (ILSI), a nonprofit, public foundation, was established in 1978 to advance the sciences of nutrition, toxicology, and food safety. ILSI promotes the resolution of health and safety issues in these areas by sponsoring research, conferences, publications, and educational programs. Through ILSI's programs, scientists from government, academia, and industry unite their efforts to resolve issues of critical importance to the public. As part of its commitment to understanding and resolving health and safety issues, ILSI is pleased to sponsor this series of monographs that consolidates new scientific knowledge, defines research needs, and provides a background for the effective application of scientific advances in toxicology and food safety. Alex Malaspina President International Life Sciences Institute Contents Series Foreword . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi Part I. Approaches to Assessing the Toxicity of Airborne Toxicants Chapter 1. Standard-Setting as an Integrative Exercise: Alchemy, Juggling, or Science? . . . . . . . . . . . . . . . . . . . . . . . 1 D. v. Bates Chapter 2. Species Differences in Inhalation Toxicology: Variations in Exposure-Dose Relationships and Macrophage Function. . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 J. D. Brain Chapter 3. Cell Populations of the Respiratory System: Interspecies Diversity in Composition, Distribution, and Morphology . . . . . . . . . . . . . . . . . . . . . . . . 25 e. G. Plopper, A. Mir, J. St. George, N. Tyler, A. Mariassy, D. Wilson, S. Nishio, D. Cranz, J. Heidsiek, and D. Hyde Chapter 4. Comparative Metabolic Basis for the Disposition and Toxic Effects of Inhaled Materials . . . . . . . . . . . . . . . . . 41 A. R. Dahl Part II. Methodological Issues in Designing and Conducting Studies with Laboratory Animals Chapter 5. Exposure Facilities and Aerosol Generation and Characterization for Inhalation Experiments. . . . . . . . . .
Author : Robert F. Phalen
Publisher : CRC Press
Page : 174 pages
File Size : 49,8 Mb
Release : 1996-11-06
Category : Medical
ISBN : 0849333431
Conducting studies of natural and man-made air contaminants is a specialized research activity that draws upon skills from a variety of disciplines including toxicology, pharmacology, industrial hygiene, and environmental health. Methods in Inhalation Toxicology describes how knowledge from these disciplines is integrated into the design and conduct of inhalation studies. Each of the vital aspects of conducting these studies is discussed in detail, including the use of animal subjects and the related quality control and ethical considerations, air purification methodology, exposure atmosphere generation and characterization, inhalation exposure systems, and real-time and post-exposure biological assessments. These methods will enable you to conduct inhalation studies, easily adding any specific measures of particular interest to your research. The book covers techniques needed to: provide suitable clean air for experiments correctly generate the particles and gases being studied select the proper exposure system monitor the exposure prepare tissues for study ensure that animals do not have confounding lung disease The helpful descriptions and detailed lists of suppliers of preferred equipment and materials will help you to perform valid, reproducible inhalation toxicology studies. Methods in Inhalation Toxicology is a perfect textbook for students in toxicology programs, as well as for scientists who conduct inhalation studies in both academic and industrial environments.
Author : Roger O. McClellan
Publisher : CRC Press
Page : 678 pages
File Size : 51,9 Mb
Release : 1995-09-25
Category : Medical
ISBN : 1439805571
Recent developments have provided new data on the subject of inhalation toxicology, requiring an update of the previous edition of this popular text. Like the first, this second edition explains the basic concepts and quantitative approaches in inhalation toxicology, and it gives a comprehensive treatment of evaluations of respiratory responses to inhaled particles and gases. The author here explores new understanding of the role of cytokines in pulmonary inflammation and risk assessment. Immunologists, oncologists, respiratory specialists and students in those fields will find Concepts In Inhalation Toxicology to be essential to their practice.
Author : U MOHR (Ed)
Publisher : Unknown
Page : 128 pages
File Size : 46,9 Mb
Release : 1988
Category : Electronic
ISBN : OCLC:985818351
APPROACHES TO ASSESSING THE TOXICITY OF AIRBORNE TOXICANTS; STANDARD-SETTING AS AN INTEGRATIVE EXERCISE: ALCHEMY, JUGGLING, OR SCIENCE; SPECIES DIFFERENCES IN INHALATION TOXICOLOGY: VARIATIONS IN EXPOSURE-DOSE RELATIONSHIPS AND MACROPHAGE FUNCTION; CELL POPULATIONS OF THE RESPIRATORY SYSTEM: INTERSPECIES DIVERSITY IN COMPOSITION, DISTRIBUTION AND MORPHOLOGY; COMPARATIVE METABOLIC BASIS FOR THE DISPOSITION AND TOXIC EFFECTS OF INHALED MATERIALS; METHODOLOGICAL ISSUES IN DESIGNING AND CONDUCTING STUDIES WITH LABORATORY ANIMALS; EXPOSURE FACILITIES AND AEROSOL GENERATION AND CHARACTERIZATION FOR INHALATION EXPERIMENTS; DIFFERENT METHODS USED IN ACUTE AND SUBCHRONIC INHALATION STUDIES OF POTENTIAL LUNG IRRITANTS, WITH PARTICULAR ATTENTION TO LUNG FUNCTION; CHRONIC INHALATION TOXICITY STUDIES: PROTOCOLS AND PITFALLS; CARCINOGENICITY PROTOCOLS.
Author : Harry Salem,Sidney A. Katz
Publisher : CRC Press
Page : 616 pages
File Size : 41,6 Mb
Release : 2014-08-19
Category : Medical
ISBN : 9781466552739
The lungs provide a significant opportunity for the introduction of both therapeutic and toxic chemicals into the human body. In occupational and domestic environments, hazardous chemicals can enter the body through the lungs via gases, aerosols, and particulates from natural and anthropogenic sources. Fully updated with new research and discoveries since the last edition, Inhalation Toxicology, Third Edition presents contributions from internationally recognized scientists in the academic, commercial/industrial, and governmental sectors. A pragmatic resource for practicing professionals and students, the book comprehensively examines the relationship between the respiratory system and the toxicology of inhaled substances. Topics include: Regulatory aspects of exposure and testing Testing equipment and procedures Respiratory allergy and irritation of the respiratory tract Risk assessment Toxicology theory Toxicology modeling Toxic effects of some individual toxicants New topics in this third edition include collection and characterization of airborne particulate matter, the inhalation toxicology of asbestos fibers and nanoparticles, and the development of lung-on-a-chip technology for predicting in vivo responses. Each chapter concludes with thought-provoking questions and answers, enhancing the book’s educational utility.
Author : Anthony J. Hickey
Publisher : CRC Press
Page : 400 pages
File Size : 48,5 Mb
Release : 1992
Category : Medical
ISBN : UOM:39015025232417
This thoroughly revised and expanded reference provides authoritative discussions on the physiologic, pharmacologic, metabolic, molecular, cellular and physicochemical factors, influencing the efficacy and utilization of pharmaceutical aerosol. It analyzes the latest science and developments in the generation, administration and characterization of these compounds, showcasing current clinical applications, the efficiency and limitations of major aerosol products and emerging aerosol therapies impacting the field.
Author : Robert F. Phalen
Publisher : CRC PressI Llc
Page : 277 pages
File Size : 45,8 Mb
Release : 1984
Category : Medical
ISBN : 0849354692
1. Aerosol and gases; 2. Basic morphology and physiology of the respiratory tract; 3. Establishing and controlling exposure environments; 4. Characterizing the exposure; 5. Methods for exposure animals.
Author : Robert F. Phalen
Publisher : CRC Press
Page : 288 pages
File Size : 42,5 Mb
Release : 2008-10-22
Category : Medical
ISBN : 0849314003
This significantly updated and expanded new edition presents the scientific foundations of inhalation research essential to the design and conduct of toxicologic studies. It incorporates the major advances that have been made in the field, including recent advances in biology and the rapidly increasing global concerns and studies on particulate air pollution. The Second Edition was motivated by: new developments in the ultrafine particle health effects and concentrated aerosol research advances in understanding postnatal lung growth and the deposition and clearance of inhaled particles new techniques in toxicity testing the explosion of knowledge in the genetic and molecular realms the introduction of a large number of transgenic animal models updated ethical guidelines for animal testing the emergence of aerosol medicine the growing threat of aerosol-related terrorism increased appreciation of nonpulmonary effects of inhaled substances use of medical scanning techniques to study respiratory tract structure the introduction of new inhalation exposure systems the emergence of aerosol concentrators for use in air pollution studies
Author : Peter Grosdanoff
Publisher : Unknown
Page : 692 pages
File Size : 43,7 Mb
Release : 1984
Category : Gases, Asphyxiating and poisonous
ISBN : UCLA:L0063659049
INTRODUCTION INTO METHODOLOGICAL PROBLEMS IN INHALATION TOXICOLOGY; PROBLEMS AND CONCEPT OF SHORT TERM INHALATION TOXICITY STUDIES; ACUTE ORAL AND INHALATION TOXICITY; A CORRELATION OF EXPERIMENTAL RESULTS; HEAD ONLY AND NOSE ONLY EXPOSURE; WHOLE BODY EXPOSURE; VAPOR ATMOSPHERE GENERATION AND ANALYSIS; GENERATION OF AEROSOL FROM LIQUID AND SOLID TEST SUBSTANCE AND SAMPLING FOR AEROSOL ANALYSIS; GENERATION OF FIBROUS DUSTS AND SAMPLING FOR ANALYSIS; CRITERIA FOR THE SELECTION OF SUITABLE EXPERIMENTAL ANIMALS AND KEEPING METHODS FOR INHALATION EXPERIMENTS MAKING SPECIAL ALLOWANCE FOR LONG TIME EXPERIMENTS; THE SUITABILITY OF THE SYRIAN GOLDEN HAMSTER FOR CHRONIC INHALATION EXPERIMENTS; STUDIES OF PARTICLE DEPOSITION AND CLEARANCE IN HUMANS; DEPOSITION AND LUNG CLEARANCE OF INHALED PARTICLES IN EXPERIMENTAL ANIMALS; NON INHALATORY ADMINISTRATION INTO THE RESPIRATORY TRACT; ON THE PROBLEMS OF EXPERIMENTAL CARCINOGENICITY STUDIES WITH FIBROUS DUSTS ADMINISTERED INTRAPERITONEALLY, INTRATRACHEALLY, AND BY INHALATION; A REVIEW OF PULMONARY FUNCTION TESTS IN SMALL LABORATORY ANIMALS AND THEIR CORRELATION WITH HUMAN STUDIES; TESTING OF PULMONARY FUNCTION IN CONSCIOUS EXPERIMENTAL ANIMALS; LUNG FUNCTION TESTS ON HAMSTERS AND RATS USING THE WHOLE BODY PLETHYSMOGRAPH; COMPOSITION OF AIRWAY SECRETIONS IN EXPERIMENTAL BRONCHITIS ON THE RAT; ASSESSMENT OF EXTRAPULMONARY EFFECTS; PHYSIOLOGICAL CHANGES INDUCED BY INHALED SUBSTANCES WITH SPECIAL REFERENCE TO NEUROBEHAVIOURAL EFFECTS; BIOCHEMICAL ANALYSIS IN INHALATION TOXICITY STUDIES; ASSESSMENT OF INHALATION PHARMACOKINETICS IN CLOSED EXPOSURE SYSTEMS.
Author : Inhalation Toxicology Research Institute
Publisher : Unknown
Page : 400 pages
File Size : 44,9 Mb
Release : 1973
Category : Radioactive substances
ISBN : CHI:77559892
Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Committee on the Review of the Health Effects of Electronic Nicotine Delivery Systems
Publisher : National Academies Press
Page : 775 pages
File Size : 40,6 Mb
Release : 2018-05-18
Category : Medical
ISBN : 9780309468374
Millions of Americans use e-cigarettes. Despite their popularity, little is known about their health effects. Some suggest that e-cigarettes likely confer lower risk compared to combustible tobacco cigarettes, because they do not expose users to toxicants produced through combustion. Proponents of e-cigarette use also tout the potential benefits of e-cigarettes as devices that could help combustible tobacco cigarette smokers to quit and thereby reduce tobacco-related health risks. Others are concerned about the exposure to potentially toxic substances contained in e-cigarette emissions, especially in individuals who have never used tobacco products such as youth and young adults. Given their relatively recent introduction, there has been little time for a scientific body of evidence to develop on the health effects of e-cigarettes. Public Health Consequences of E-Cigarettes reviews and critically assesses the state of the emerging evidence about e-cigarettes and health. This report makes recommendations for the improvement of this research and highlights gaps that are a priority for future research.
Author : Marc Williams,Gunda Reddy,Michael Quinn,Mark S Johnson
Publisher : Elsevier
Page : 722 pages
File Size : 53,7 Mb
Release : 2015-05-21
Category : Medical
ISBN : 9780128004807
Wildlife Toxicity Assessments for Chemicals of Military Concern is a compendium of chemical-specific toxicity information with discussions on the rationale and development of Wildlife Toxicity Reference Values (TRVs) intended for use on terrestrial wildlife for risk assessment applications. Substances covered include military-related chemicals including explosives, propellants, pesticides and metals. Wildlife Toxicity Assessments for Chemicals of Military Concern is a much-needed resource designed to meet the needs of those seeking toxicological information for ecological risk assessment purposes. Each chapter targets a specific chemical and considers the current knowledge of the toxicological impacts of chemicals to terrestrial wildlife including mammalian, avian, amphibian and reptilian species. Provides detailed information on how Wildlife Toxicity Values (TRVs) for military chemicals of concern are derived and evaluated. Covers wildlife toxicity assessments of explosives, metals and environmental chemicals. Compiles relevant information on the environmental effects of chemicals on wildlife in relation to public and environmental health.