Synaptic Plasticity In The Hippocampus

Author : Helmut L. Haas,György Buzsaki
Publisher : Springer Science & Business Media
Page : 219 pages
File Size : 42,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642732027

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Synaptic Plasticity in the Hippocampus by Helmut L. Haas,György Buzsaki Pdf

This is the second time that I have had the honor of opening an interna tional symposium dedicated to the functions of the hippocampus here in Pecs. It was a pleasure to greet the participants in the hope that their valuable contributions will make this meeting a tradition in this town. As one of the hosts of the symposium, I had the sorrowful duty to remind you of the absence of a dear colleague, Professor Graham God dard. His tragic and untimely death represents the irreparable loss of both a friend and an excellent researcher. This symposium is dedicated to his memory. If I compare the topics of the lectures of this symposium with those of the previous one, a striking difference becomes apparent. A dominating tendency of the previous symposium was to attempt to define hippocam pal function or to offer data relevant to supporting or rejecting existing theoretical positions. No such tendency is reflected in the titles of the present symposium, in which most of the contributions deal with hip pocampal phenomena at the most elementary level. Electrical, biochemi cal, biophysical, and pharmacological events at the synaptic, membrane, or intracellular level are analyzed without raising the question of what kind of integral functions these elementary phenomena are a part of.

Author : Federico Bermudez-Rattoni
Publisher : CRC Press
Page : 368 pages
File Size : 42,6 Mb
Release : 2007-04-17
Category : Science
ISBN : 1420008412

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Neural Plasticity and Memory by Federico Bermudez-Rattoni Pdf

A comprehensive, multidisciplinary review, Neural Plasticity and Memory: From Genes to Brain Imaging provides an in-depth, up-to-date analysis of the study of the neurobiology of memory. Leading specialists share their scientific experience in the field, covering a wide range of topics where molecular, genetic, behavioral, and brain imaging techniques have been used to investigate how cellular and brain circuits may be modified by experience. In each chapter, researchers present findings and explain their innovative methodologies. The book begins by introducing key issues and providing a historical overview of the field of memory consolidation. The following chapters review the putative genetic and molecular mechanisms of cell plasticity, elaborating on how experience could induce gene and protein expression and describing their role in synaptic plasticity underlying memory formation. They explore how putative modifications of brain circuits and synaptic elements through experience can become relatively permanent and hence improve brain function. Interdisciplinary reviews focus on how nerve cell circuitry, molecular expression, neurotransmitter release, and electrical activity are modified during the acquisition and consolidation of long-term memory. The book also covers receptor activation/deactivation by different neurotransmitters that enable the intracellular activation of second messengers during memory formation. It concludes with a summary of current research on the modulation and regulation that different neurotransmitters and stress hormones have on formation and consolidation of memory.

Author : Ales Stuchlik
Publisher : BoD – Books on Demand
Page : 180 pages
File Size : 55,5 Mb
Release : 2018-07-11
Category : Medical
ISBN : 9781789233568

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The Hippocampus by Ales Stuchlik Pdf

The hippocampus is an important brain region, a true central hub for memory of various kinds and other processes. Neuropsychiatric disorders such as Alzheimer's disease, drug addiction, and schizophrenia are characterized by hippocampal alterations. The dentate gyrus of the hippocampus is a site exhibiting adult neurogenesis. This book covers the topic of the hippocampus from various perspectives. It discusses adult neurogenesis, effect of enriched environments on hippocampal plasticity, and long-term potentiation-associated gene expression. The book also addresses multiscale representations of complex environments and strategies in the hippocampus-dependent spatial tasks. Finally, insight into the hippocampus as a link between negative affect and relapse to psychostimulants is provided. The book collects evidence of various hippocampal functions in healthy and disordered brain.

Author : Per Andersen
Publisher : Oxford University Press
Page : 892 pages
File Size : 51,7 Mb
Release : 2007
Category : Medical
ISBN : 0195100271

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The Hippocampus Book by Per Andersen Pdf

The hippocampus is one of a group of remarkable structures embedded within the brain's medial temporal lobe. Long known to be important for memory, it has been a prime focus of neuroscience research for many years. The Hippocampus Book promises to facilitate developments in the field in a major way by bringing together, for the first time, contributions by leading international scientists knowledgeable about hippocampal anatomy, physiology, and function. This authoritative volume offers the most comprehensive, up-to-date account of what the hippocampus does, how it does it, and what happens when things go wrong. At the same time, it illustrates how research focusing on this single brain structure has revealed principles of wider generality for the whole brain in relation to anatomical connectivity, synaptic plasticity, cognition and behavior, and computational algorithms. Well-organized in its presentation of both theory and experimental data, this peerless work vividly illustrates the astonishing progress that has been made in unraveling the workings of the brain. The Hippocampus Book is destined to take a central place on every neuroscientist's bookshelf.

Author : Daniel Laskowitz,Gerald Grant
Publisher : CRC Press
Page : 412 pages
File Size : 53,9 Mb
Release : 2015-12-01
Category : Medical
ISBN : 9781498766579

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Translational Research in Traumatic Brain Injury by Daniel Laskowitz,Gerald Grant Pdf

Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.

Author : Helmut L. Haas
Publisher : Springer Verlag
Page : 215 pages
File Size : 55,8 Mb
Release : 1988-01-01
Category : Science
ISBN : 0387185992

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Synaptic Plasticity in the Hippocampus by Helmut L. Haas Pdf

Author : Catherine Belzung,Peter Wigmore
Publisher : Springer Science & Business Media
Page : 447 pages
File Size : 44,5 Mb
Release : 2014-07-08
Category : Medical
ISBN : 9783642362323

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Neurogenesis and Neural Plasticity by Catherine Belzung,Peter Wigmore Pdf

This volume brings together authors working on a wide range of topics to provide an up to date account of the underlying mechanisms and functions of neurogenesis and synaptogenesis in the adult brain. With an increasing understanding of the role of neurogenesis and synaptogenesis it is possible to envisage improvements or novel treatments for a number of diseases and the possibility of harnessing these phenomena to reduce the impact of ageing and to provide mechanisms to repair the brain.

Author : Christian Hölscher
Publisher : Cambridge University Press
Page : 508 pages
File Size : 44,8 Mb
Release : 2005-09-29
Category : Medical
ISBN : 052101803X

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Neuronal Mechanisms of Memory Formation by Christian Hölscher Pdf

Long-term potentiation (LTP) is the most dominant model for neuronal changes that might encode memory. LTP is an elegant concept that meets many criteria set up by theoreticians long before the model's discovery, and also fits the anatomical data of learning-dependent synapse changes. Since the discovery of LTP, the question has remained regarding how closely LTP produced in vitro by artificial stimulation of neurons actually models putative learning-induced synaptic changes. A number of recent investigations have tried to correlate synaptic changes observed after learning with changes produced by artificial stimulation of neurons. Some of these studies have failed to find a correlation between the two forms of synaptic plasticity, signalling a need to discuss the concept of LTP and possible alternate processes that could fit the available data. This book presents a selection of ideas that range from supporters of the LTP theory to different novel concepts that have yet to be investigated. This volume will prepare the ground for research in this area in the new millennium.

Author : Matcheri Keshavan,Shaun Eack
Publisher : Cambridge University Press
Page : 199 pages
File Size : 49,7 Mb
Release : 2019-03-21
Category : Medical
ISBN : 9781107194786

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Cognitive Enhancement in Schizophrenia and Related Disorders by Matcheri Keshavan,Shaun Eack Pdf

A practical guide on how to assess and treat schizophrenia and related disorders using cognitive rehabilitation.

Author : Adriana Galván
Publisher : Cambridge University Press
Page : 341 pages
File Size : 50,6 Mb
Release : 2017-07-10
Category : Medical
ISBN : 9781107089921

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The Neuroscience of Adolescence by Adriana Galván Pdf

Written by an award-winning developmental neuroscientist, this is a comprehensive and cutting-edge account of the latest research on the adolescent brain.

Author : Joseph I. Tracy,Benjamin M. Hampstead,K. Sathian
Publisher : Oxford University Press, USA
Page : 433 pages
File Size : 48,7 Mb
Release : 2014-12-02
Category : Medical
ISBN : 9780199965243

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Cognitive Plasticity in Neurologic Disorders by Joseph I. Tracy,Benjamin M. Hampstead,K. Sathian Pdf

This volume makes clear that the cognitive and behavioural symptoms of neurologic disorders and syndromes are dynamic and changing. Each chapter describes the neuroplastic processes at work in a particular condition, giving rise to these ongoing cognitive changes.

Author : Sam Fazeli,Graham L. Collingridge
Publisher : Garland Science
Page : 304 pages
File Size : 43,5 Mb
Release : 2020-08-18
Category : Science
ISBN : 9781000140989

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Cortical Plasticity by Sam Fazeli,Graham L. Collingridge Pdf

This book provides an insight into the rapidly growing field of cortical plasticity. It brings together diverse experimental approaches to the study of activity-dependent changes in neuronal connections, as exemplified by long-term potentiation (LTP) and long-term depression (LTD).

Author : Leon L. Voronin
Publisher : Springer Science & Business Media
Page : 315 pages
File Size : 47,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642476150

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Synaptic Modifications and Memory by Leon L. Voronin Pdf

Understanding of memory and learning is one of the major goals of neuroscientists and psychologists. The author first introduces the reader into the current state of knowledge of the mechanisms underlying memory by providing extensive reviews of contemporary results including behavioural approaches and molecular studies. He presents results of his group obtained by analysing elec- trical activity - including single neuron meassures. As a major experimental model the phenomenon of hippocampal long- term potentiation was studied. The so-called quantal analy- sis - a quantitative method - was applied to study mammalian brain plasticity. Short- and long-term synaptic plasticities were registered both in vivo and in vitro mammalian brain preparations. Results show the involvement of mainly presynaptic location in memory, however, the possible involvement of postsynaptic mechanisms is indicated by changes in quantal amplitude as shown by the author.

Author : Michael R. Kreutz,Carlo Sala
Publisher : Springer Science & Business Media
Page : 611 pages
File Size : 45,5 Mb
Release : 2012-02-18
Category : Medical
ISBN : 9783709109311

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Synaptic Plasticity by Michael R. Kreutz,Carlo Sala Pdf

This book introduces the current concepts of molecular mechanisms in synaptic plasticity and provides a comprehensive overview of cutting-edge research technology used to investigate the molecular dynamics of the synapses. It explores current concepts on activity-dependent remodeling of the synaptic cytoskeleton and presents the latest ideas on the different forms of plasticity in synapses and dendrites. Synaptic Plasticity in Health and Disease not only supplies readers with extensive knowledge on the latest developments in research, but also with important information on clinical and applied aspects. Changes in spine synapses in different brain disease states, so-called synaptopathies, are explained and described by experts in the field. By outlining basic research findings as well as physiological and pathophysiological impacts on synaptic plasticity, the book represents an essential state-of-the-art work for scientists in the fields of biochemistry, molecular biology and the neurosciences, as well as for doctors in neurology and psychiatry alike.

Author : Tim V. P. Bliss,G. L. Collingridge,Richard G. M. Morris
Publisher : Unknown
Page : 440 pages
File Size : 47,7 Mb
Release : 2004
Category : Medical
ISBN : 0198530307

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Long-term Potentiation by Tim V. P. Bliss,G. L. Collingridge,Richard G. M. Morris Pdf

In the thirty years since its discovery by Terje Lomo and Tim Bliss, Long Term Potentiation (LTP) has become one of the most extensively studied topics in contemporary neuroscience. In LTP the strength of synapses between neurons is potentiated following brief but intense activation. LTP is thought to play a central role in learning and memory, though the exact nature of its role is less clear. In spite of years of research, there are many questions about LTP regarding its functional relevance that remain unanswered - for example, is it a model of memory formation, or is the actual neural mechanism used by the brain to store information?This volume presents a state of the art account of LTP. It begins with lively accounts, by the scientists most closely involved, of the discovery of LTP and of the experiments that established its basic properties and induction mechanisms. Later contributions contain reviews and new research that cover the range of molecular, cellular, physiological and behavioural approaches to the study of LTP. Provocative, accessible, and authoritative, this book makes it clear why LTP continues in equal measure to puzzle and beguile neuroscientists today.Advance praise for Long Term Potentiation: 'This book provides a definitive overview of the development of ideas about synaptic plasticity and about the wide range of current research in this fascinating field.' Colin Blakemore, University of OxfordReadership: Neuroscientists from postgraduate level upwards