Mechanisms Of Toxicity And Metabolism

Author : N. T. Kärki
Publisher : Elsevier
Page : 268 pages
File Size : 49,6 Mb
Release : 2014-05-18
Category : Medical
ISBN : 9781483145693

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Mechanisms of Toxicity and Metabolism by N. T. Kärki Pdf

Mechanisms of Toxicity and Metabolism is the sixth volume of the proceedings of the Sixth International Congress of Pharmacology, organized by the Finnish Pharmacological Society and held in Helsinki, Finland, on July 20-25, 1975. Contributors focus on the findings concerning the mechanisms of toxicity and metabolism and the developments in pharmacology and related areas of research. This volume has 24 chapters divided into four sections. After discussing the developmental aspects of drug metabolism and enzyme inhibitors of microbial origin, this book turns its attention to the interrelationships among various enzyme systems and physiological processes that are known to affect the distribution and metabolism of drugs. This text also highlights the reaction mechanisms of cytochrome P-450; the link between microsomal drug oxidation and glucuronidation; and the pharmacokinetics of the first pass effect. The reader is then introduced to the toxicity of food additives and the toxicity and metabolism of plasticizers and plastics. This volume concludes with a chapter that evaluates some of the biochemical and pharmacologic effects of di-2-ethylhexyl phthalate (DEHP). This book will appeal to scientists representing all the major areas of pharmacology, including clinical pharmacology and toxicology, as well as to internists, psychiatrists, neurologists, and anesthesiologists.

Author : H. Rašková
Publisher : Elsevier
Page : 114 pages
File Size : 44,8 Mb
Release : 2013-10-22
Category : Medical
ISBN : 9781483157207

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Mechanisms of Drug Toxicity by H. Rašková Pdf

Mechanisms of Drug Toxicity, Volume 4 presents the proceedings of the 3rd International Pharmacological Meeting held in Sao Paulo, Brazil in 1966. The book discusses the drug-induced pathobiotic effects; the mechanisms of adverse reactions; and enzyme induction in the mechanism of chronic toxicity. The text also describes the influence of inducing substances on the growth of liver and microsomal electron transport systems; the quantitative aspects of chronic toxicity; and the facts and fallacies in predicting drug effects in human.

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 40,9 Mb
Release : 1975
Category : Electronic
ISBN : OCLC:882540806

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Mechanisms of Toxicity and Metabolism by Anonim Pdf

Author : Niilo Tapio Kärki
Publisher : Pergamon
Page : 282 pages
File Size : 51,7 Mb
Release : 1976
Category : Medical
ISBN : UOM:39015003232454

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Mechanisms of Toxicity and Metabolism by Niilo Tapio Kärki Pdf

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology
Publisher : National Academies Press
Page : 300 pages
File Size : 52,6 Mb
Release : 2007-11-19
Category : Science
ISBN : 9780309178891

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Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology Pdf

The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.

Author : National Research Council,Policy and Global Affairs,Science, Technology, and Law Program,Committee on the Use of Third Party Toxicity Research with Human Research Participants
Publisher : National Academies Press
Page : 226 pages
File Size : 40,8 Mb
Release : 2004-06-04
Category : Science
ISBN : 9780309166416

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Intentional Human Dosing Studies for EPA Regulatory Purposes by National Research Council,Policy and Global Affairs,Science, Technology, and Law Program,Committee on the Use of Third Party Toxicity Research with Human Research Participants Pdf

The EPA commissioned The National Academies to provide advice on the vexing question of whether and, if so, under what circumstances EPA should accept and consider intentional human dosing studies conducted by companies or other sources outside the agency (so-called third parties) to gather evidence relating to the risks of a chemical or the conditions under which exposure to it could be judged safe. This report recommends that such studies be conducted and used for regulatory purposes only if all of several strict conditions are met, including the following: The study is necessary and scientifically valid, meaning that it addresses an important regulatory question that can't be answered with animal studies or nondosing human studies; The societal benefits of the study outweigh any anticipated risks to participants. At no time, even when benefits beyond improved regulation exist, can a human dosing study be justified that is anticipated to cause lasting harm to study participants; and All recognized ethical standards and procedures for protecting the interests of study participants are observed. In addition, EPA should establish a Human Studies Review Board (HSRB) to evaluate all human dosing studiesâ€"both at the beginning and upon completion of the experimentsâ€"if they are carried out with the intent of affecting the agency's policy-making.

Author : W. Norman Aldridge
Publisher : CRC Press
Page : 270 pages
File Size : 48,7 Mb
Release : 1996-02-15
Category : Medical
ISBN : 0748404139

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Mechanisms and Concepts in Toxicology by W. Norman Aldridge Pdf

Illustrating concepts and types of toxicity from a mechanistic point of view, this book focuses on research procedures in toxicology. The book uses examples of chemical intoxicants to illustrate mechanisms in each stage of toxicity.

Author : Sam Kacew
Publisher : CRC Press
Page : 332 pages
File Size : 51,9 Mb
Release : 2018-01-18
Category : Medical
ISBN : 9781351079976

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Drug Toxicity and Metabolism in Pediatrics by Sam Kacew Pdf

The aim of this text is to examine the physiological development of the fetus. It allows the reader to study the unique pharmacokinetic and metabolic features of newborns and gives specific examples of drug metabolism in the newborn. The purpose of this book is to enhance the current knowledge of pharmacology of the newborn by observing the embryo and placenta in normal and abnormal development, placental transfer of drugs, metabolic pathways, and metabolism of specific drugs such as theophylline, benzodiazepines, and antibiotics. This is a useful book for those involved in pediatric research, pharmacology, toxicology, experimental therapeutics and biology.

Author : Anonim
Publisher : Academic Press
Page : 288 pages
File Size : 43,7 Mb
Release : 2019-07-13
Category : Medical
ISBN : 9780128173176

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Drug-Induced Liver Injury by Anonim Pdf

Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Author : National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Developmental Toxicology
Publisher : National Academies Press
Page : 348 pages
File Size : 50,8 Mb
Release : 2000-12-21
Category : Nature
ISBN : 9780309070867

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Scientific Frontiers in Developmental Toxicology and Risk Assessment by National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Developmental Toxicology Pdf

Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.

Author : John Timbrell
Publisher : CRC Press
Page : 412 pages
File Size : 49,7 Mb
Release : 1999-10-21
Category : Medical
ISBN : 0748407367

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Principles of Biochemical Toxicology, Third Edition by John Timbrell Pdf

Research into the biochemical basis of toxicology has expanded rapidly over recent years, amidst concerns over the adverse effects of drugs, environmental pollution and occupational hazards. Following on from the acclaimed first two editions of Principles of Biochemical Toxicology, John Timbrell has expanded the text to include: summary sections questions and model answers thoroughly revised artwork These features, plus the new easy-to-read format will make biochemical toxicology more accessible to undergraduates and postgraduates coming across the subject for the first time, particularly when undertaking self-directed study. This comprehensive textbook provides a thorough explanation of dose-response relationships; disposition and metabolism; toxic responses to foreign compounds, and detailed examples to illustrate mechanisms of toxicity. There is also an expanded and updated bibliography, directing the reader to further reading if required. Students and lecturers will find the clear and concise approach, which established this book as the leading textbook in its field, an essential aid to learning and teaching.

Author : John A. Timbrell
Publisher : Unknown
Page : 259 pages
File Size : 44,6 Mb
Release : 1982
Category : Toxicology
ISBN : 0685104931

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Principles of Biochemical Toxicology by John A. Timbrell Pdf

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Safe Drinking Water Committee,Subcommittee on Pharmacokinetics in Risk Assessment
Publisher : National Academies Press
Page : 507 pages
File Size : 41,6 Mb
Release : 1987-02-01
Category : Nature
ISBN : 9780309037754

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Drinking Water and Health, Volume 8 by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Safe Drinking Water Committee,Subcommittee on Pharmacokinetics in Risk Assessment Pdf

Pharmacokinetics, the study of the movement of chemicals within the body, is a vital tool in assessing the risk of exposure to environmental chemicals. This bookâ€"a collection of papers authored by experts in academia, industry, and governmentâ€"reviews the progress of the risk-assessment process and discusses the role of pharmacokinetic principles in evaluating risk. In addition, the authors discuss software packages used to analyze data and to build models simulating biological phenomena. A summary chapter provides a view of trends in pharmacokinetic modeling and notes some prospective fields of study.

Author : Yvonne Will,James A. Dykens
Publisher : John Wiley & Sons
Page : 816 pages
File Size : 49,9 Mb
Release : 2018-03-23
Category : Science
ISBN : 9781119329749

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Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants by Yvonne Will,James A. Dykens Pdf

Developed as a one-stop reference source for drug safety and toxicology professionals, this book explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided. • Covers both basic science and applied technology / methods • Allows readers to understand the basis of mitochondrial function, the preclinical assessments used, and what they reveal about drug effects • Contains both in vitro and in vivo methods for analysis, including practical screening approaches for drug discovery and development • Adds coverage about mitochondrial toxicity underlying organ injury, clinical reports on drug classes, and discussion of environmental toxicants affecting mitochondria

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee to Review EPA's Draft IRIS Assessment of Formaldehyde
Publisher : National Academies Press
Page : 204 pages
File Size : 52,5 Mb
Release : 2011-05-31
Category : Science
ISBN : 9780309211963

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Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee to Review EPA's Draft IRIS Assessment of Formaldehyde Pdf

Formaldehyde is ubiquitous in indoor and outdoor air, and everyone is exposed to formaldehyde at some concentration daily. Formaldehyde is used to produce a wide array of products, particularly building materials; it is emitted from many sources, including power plants, cars, gas and wood stoves, and cigarettes; it is a natural product in come foods; and it is naturally present in the human body as a metabolic intermediate. Much research has been conducted on the health effects of exposure to formaldehyde, including effects on the upper airway, where formaldehyde is deposited when inhaled, and effects on tissues distant from the site of initial contact. The U.S. Environmental Protection Agency (EPA) released noncancer and cancer assessments of formaldehyde for its Intergated Risk Information System (IRIS) in 1990 and 1991, respectively. The agency began reassessing formaldehyde in 1998 and released a draft IRIS assessment in June 2010. Given the complexity of the issues and the knowledge that the assessment will be used as the basis of regulatory decisions, EPA asked the National Research Council (NRC) to conduct an independent scientific review of the draft IRIS assessment. In this report, the Committee to Review EPA's Draft IRIS Assessment of Formaldehyde first addresses some general issues associated with the draft IRIS assessment. The committee next focuses on questions concerning specific aspects of the draft assessment, including derivation of the reference concentrations and the cancer unit risk estimates for formaldehyde. The committee closes with recommendations for improving the IRIS assessment of formaldehyde and provides some general comments on the IRIS development process.